NEDD8-STON binds TOR1 hexamer and COP9 complex

Stable Identifier
R-HSA-8863721
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

STON2 protein levels are stabilized by deneddylation, restoring the endocytic uptake of SYT1. Deneddylation is mediated by TOR1A and the CSN4 subunit of the COP9 signalosome, both of which directly bind to STON2 (Granata et al, 2011).

Literature References
PubMed ID Title Journal Year
21102408 CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process

Granata, A, Koo, SJ, Haucke, V, Schiavo, G, Warner, TT

EMBO J. 2011
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