COP9 and TOR1 deneddylate STON2

Stable Identifier
R-HSA-8863723
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Deneddylation of STON2 by TOR1A and the COP9 signalosome stabilize the protein, allowing it to function in the endocytosis of cargo such as the SYT proteins (Granata et al, 2011).

Literature References
PubMed ID Title Journal Year
21102408 CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process

Granata, A, Koo, SJ, Haucke, V, Schiavo, G, Warner, TT

EMBO J. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NEDD8-specific protease activity of NEDD8-STONs:TOR1 hexamer:COP9 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed