Reactome: A Curated Pathway Database

COP9 and TOR1 deneddylate STON2

Stable Identifier
R-HSA-8863723
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Deneddylation of STON2 by TOR1A and the COP9 signalosome stabilize the protein, allowing it to function in the endocytosis of cargo such as the SYT proteins (Granata et al, 2011).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
NEDD8-specific protease activity of NEDD8-STONs:TOR1 hexamer:COP9 [cytosol] NEDD8-STONs:TOR1 hexamer:COP9 [cytosol] NEDD8-specific protease activity (0019784)
Orthologous Events