IKKB phosphorylates SNAP23

Stable Identifier
R-HSA-8863895
Type
Reaction [transition]
Species
Homo sapiens
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A major reserve of MHC-I in dendritic cells reside within the endocytic recycling compartments (ERC). MHC-I trafficking to the ERC is regulated by the activity of Rab11a and subsequent trafficking from ERC to phagosomes is controlled by TLR-MyD88-IKK2-dependent phosphorylation of phagosomal SNAP23. Toll-like receptor (TLR) signalling regulate cross-presentation as they regulate phagocytosis and phagolysosomal fusion (Nair et al. 2011). MHC-I bearing ERC are enriched with R-SNAREs like RAB11a, VAMP3, and VAMP8. These SNARE molecules can interact with Q-SNARE SNAP23 present on phagosomes and this mediates membrane fusion. This interaction of SNAP23 with R-SNAREs require phosphorylation of SNAP23 (on Ser-95) by IKK2, and IKK2 is activated by TLR signalling. SNAP23 phosphorylation may increase SNAP23 binding to SNAREs. It may also regulate platelet and mast cell secretion (Karim et al. 2013, Suziki & Verma 2008).

Literature References
PubMed ID Title Journal Year
18692471 Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation

Suzuki, K, Verma, IM

Cell 2008
25083866 TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation

Nair-Gupta, P, Baccarini, A, Tung, N, Seyffer, F, Florey, O, Huang, Y, Banerjee, M, Overholtzer, M, Roche, PA, Tampé, R, Brown, BD, Amsen, D, Whiteheart, SW, Blander, JM

Cell 2014
23613522 IκB kinase phosphorylation of SNAP-23 controls platelet secretion

Karim, ZA, Zhang, J, Banerjee, M, Chicka, MC, Al Hawas, R, Hamilton, TR, Roche, PA, Whiteheart, SW

Blood 2013
Participants
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Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of CHUK:IKBKB:IKBKG [cytosol]
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Activity
This event is regulated
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