Transport of SEC22B, TAP and PLC from ER to ERGIC

Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In DCs subset of ER proteins including MHC-I peptide loading complex (PLC) and transporter associated with antigen processing (TAP) transit to phagosomes via the intermediate compartment ER-Golgi intermediate compartment (ERGIC) (Cebrian et al. 2011). TAP exits the ER in COPII vesicles in association with MHC class I, and that peptide translocation by TAP and binding to class I can occur in post-ER compartments (Ghanem et al. 2010). SEC22B, an ER-resident SNARE is required for the transport of PLC from ERGIC (Cebrian et al. 2011), but this step does not deliver MHC-I (Nair-Gupta et al. 2014). Instead, MHC-I are recruited from an endosomal recycling compartment (ERC), which is marked by Rab11a, VAMP3/cellubrevin, and VAMP8/endobrevin that holds large reserves of MHC-I. This step is dependent on TLR signalling (Nair-Gupta et al. 2014).

Literature References
PubMed ID Title Journal Year
25083866 TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation

Nair-Gupta, P, Baccarini, A, Tung, N, Seyffer, F, Florey, O, Huang, Y, Banerjee, M, Overholtzer, M, Roche, PA, Tampé, R, Brown, BD, Amsen, D, Whiteheart, SW, Blander, JM

Cell 2014
22153078 Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells

Cebrian, I, Visentin, G, Blanchard, N, Jouve, M, Bobard, A, Moita, C, Enninga, J, Moita, LF, Amigorena, S, Savina, A

Cell 2011
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created