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TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
Stable Identifier
R-HSA-8863953
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane
Synonyms
Antigen peptide transporter 1, TAP1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Homo sapiens)
CALR:SEC22B:STX4:TAP:TAPBP [phagocytic vesicle membrane] (Homo sapiens)
TAP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)
CALR:SEC22B:STX4:TAP:TAPBP [phagocytic vesicle membrane] (Homo sapiens)
TAP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
TAP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)
TAP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q03518 TAP1
Gene Names
TAP1, ABCB2, PSF1, RING4, Y3
Chain
chain:1-808
Reference Genes
BioGPS Gene:6890 TAP1
COSMIC (genes):TAP1 TAP1
CTD Gene:6890 TAP1
dbSNP Gene:6890 TAP1
ENSEMBL:ENSG00000168394 TAP1
ENSEMBL:ENSG00000206297 TAP1
ENSEMBL:ENSG00000224212 TAP1
ENSEMBL:ENSG00000226173 TAP1
ENSEMBL:ENSG00000227816 TAP1
ENSEMBL:ENSG00000230705 TAP1
ENSEMBL:ENSG00000232367 TAP1
HGNC:43 TAP1
KEGG Gene (Homo sapiens):6890 TAP1
Monarch:6890 TAP1
NCBI Gene:6890 TAP1
OMIM:170260 TAP1
UCSC:Q03518 TAP1
Reference Transcript
RefSeq:NM_000593.5 TAP1
RefSeq:NM_001292022.1 TAP1
Other Identifiers
0003120279
11730729_a_at
11757351_a_at
17017979
17027144
17029788
17032476
17034791
17037271
17039977
17042487
202307_s_at
2950215
2950216
2950217
2950219
2950221
2950222
2950223
2950224
2950226
2950228
2950230
2950231
2950232
2950233
2950234
2950235
2950236
2950237
40153_at
6890
8125512
8178867
8180061
A_23_P59005
GE79181
GO:0000166
GO:0002250
GO:0002376
GO:0002474
GO:0002479
GO:0003674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005783
GO:0005789
GO:0005815
GO:0005856
GO:0006810
GO:0006950
GO:0006952
GO:0008150
GO:0015031
GO:0015433
GO:0015440
GO:0015833
GO:0016020
GO:0016021
GO:0016032
GO:0016192
GO:0016887
GO:0019885
GO:0022857
GO:0023029
GO:0030176
GO:0030670
GO:0031410
GO:0032991
GO:0033116
GO:0034451
GO:0042287
GO:0042288
GO:0042605
GO:0042626
GO:0042803
GO:0042824
GO:0042825
GO:0043167
GO:0043226
GO:0043531
GO:0044403
GO:0046967
GO:0046978
GO:0046979
GO:0055085
GO:0061024
GO:1904680
GO:1990668
ILMN_1751079
PH_hs_0032801
TC06001574.hg
TC6_apd_hap1000105.hg
TC6_cox_hap2000199.hg
TC6_dbb_hap3000185.hg
TC6_mann_hap4000167.hg
TC6_mcf_hap5000174.hg
TC6_qbl_hap6000187.hg
TC6_ssto_hap7000169.hg
X57522_at
g9665247_3p_a_at
Participant Of
hasComponent
TAP [endoplasmic reticulum-Golgi intermediate compartment membrane]
Other forms of this molecule
TAP1 [phagocytic vesicle membrane]
TAP1 [endoplasmic reticulum membrane]
Inferred To
Mdr50 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Drosophila melanogaster)
abcb9 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
haf-4 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
haf-7 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Xenopus tropicalis)
tap2t [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
Homologues of TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
Homologues of TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
Homologues of TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Dictyostelium discoideum)
Homologues of TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Drosophila melanogaster)
Homologues of TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Xenopus tropicalis)
abcB3 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Dictyostelium discoideum)
tagD [endoplasmic reticulum-Golgi intermediate compartment membrane] (Dictyostelium discoideum)
tagC [endoplasmic reticulum-Golgi intermediate compartment membrane] (Dictyostelium discoideum)
tagB [endoplasmic reticulum-Golgi intermediate compartment membrane] (Dictyostelium discoideum)
abcB1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Dictyostelium discoideum)
abcB2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Dictyostelium discoideum)
abcB7 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Dictyostelium discoideum)
Mdr49 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Drosophila melanogaster)
pgp-4 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
rnf130 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Xenopus tropicalis)
abcH4 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Dictyostelium discoideum)
pgp-9 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
Tap1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
Tap1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
pgp-11 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
pgp-2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
pgp-3 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
pgp-1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
pgp-13 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
pgp-14 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
pgp-12 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
pgp-10 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
haf-1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
haf-8 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)
Cross References
RefSeq
NP_000584.2
,
NP_001278951.1
OpenTargets
ENSG00000168394
HPA
ENSG00000168394-TAP1
GeneCards
Q03518
Ensembl
ENSG00000168394
,
ENSP00000346206
,
ENSG00000226173
,
ENST00000439781
,
ENSG00000206297
,
ENSG00000232367
,
ENSP00000413080
,
ENSP00000401149
,
ENSG00000230705
,
ENST00000354258
,
ENSP00000402316
,
ENST00000383235
,
ENSP00000372722
,
ENST00000440894
,
ENSP00000405356
,
ENSP00000415660
,
ENSG00000224212
,
ENSG00000227816
,
ENST00000424897
,
ENST00000418205
,
ENST00000414467
PRO
Q03518
Orphanet
16436
HMDB Protein
HMDBP10764
PDB
5U1D
,
1JJ7
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15533 TAPBP
3
TAPBP [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863976)
TAPBP [phagocytic vesicle membrane]
(R-HSA-1236750)
TAPBP [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-983083)
0.803
14
UniProt:P30101 PDIA3
3
PDIA3 [recycling endosome membrane]
(R-HSA-8863849)
PDIA3 [phagocytic vesicle]
(R-HSA-1236870)
PDIA3 [endoplasmic reticulum lumen]
(R-HSA-901028)
0.623
5
UniProt:Q3KNW5 SLC10A6
1
SLC10A6 [plasma membrane]
(R-HSA-433091)
0.556
3
UniProt:Q14973 SLC10A1
1
SLC10A1 [plasma membrane]
(R-HSA-194116)
0.556
3
UniProt:P61769 B2M
11
B2M(21-119) [specific granule lumen]
(R-HSA-6806144)
B2M(21-119) [early endosome membrane]
(R-HSA-182298)
B2M(21-119) [extracellular region]
(R-HSA-1302721)
B2M(21-119) [tertiary granule lumen]
(R-HSA-6800179)
B2M(21-119) [phagocytic vesicle membrane]
(R-HSA-1236891)
B2M(21-119) [recycling endosome membrane]
(R-HSA-8863880)
B2M(21-119) [early endosome lumen]
(R-HSA-1236827)
B2M(21-119) [ER to Golgi transport vesicle membrane]
(R-HSA-983378)
B2M(21-119) [Golgi membrane]
(R-HSA-983403)
B2M(21-119) [endoplasmic reticulum lumen]
(R-HSA-983063)
B2M(21-119) [plasma membrane]
(R-HSA-167743)
0.527
3
UniProt:P07237 P4HB
3
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
0.499
4
UniProt:P27797 CALR
6
CALR [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
0.499
2
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