PTPN12 dephosphorylates PDGFRB at Y1021

Stable Identifier
R-HSA-8864036
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Protein tyrosine phosphatase PTNP12 dephosphorylates activated PDFRB (PDGF receptor beta) at tyrosine residue Y1021, which contributes to the tumor suppressor role of PTPN12 in triple negative breast cancer in addition to PTPN12-mediated dephosphorylation of ERBB2 (HER2) at Y1248 (Sun et al. 2011).

Literature References
PubMed ID Title Journal Year
21376233 Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase

Sun, T, Aceto, N, Meerbrey, KL, Kessler, JD, Zhou, C, Migliaccio, I, Nguyen, DX, Pavlova, NN, Botero, M, Huang, J, Bernardi, RJ, Schmitt, E, Hu, G, Li, MZ, Dephoure, N, Gygi, SP, Rao, M, Creighton, CJ, Hilsenbeck, SG, Shaw, CA, Muzny, D, Gibbs, RA, Wheeler, DA, Osborne, CK, Schiff, R, Bentires-Alj, M, Elledge, SJ, Westbrook, TF

Cell 2011
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN12 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created