Reactome | PTPN18 [cytosol]

PTPN18 [cytosol]

Stable Identifier

R-HSA-8864101

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein phosphatase non-receptor type 18, BDP1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99952 PTPN18

Gene Names

PTPN18, BDP1

Chain

chain:1-460

Reference Genes

BioGPS Gene:26469 PTPN18

COSMIC (genes):PTPN18 PTPN18

CTD Gene:26469 PTPN18

dbSNP Gene:26469 PTPN18

ENSEMBL:ENSG00000072135.13 PTPN18

HGNC:9649 PTPN18

KEGG Gene (Homo sapiens):26469 PTPN18

Monarch:26469 PTPN18

NCBI Gene:26469 PTPN18

OMIM:606587 PTPN18

UCSC:Q99952 PTPN18

Reference Transcript

Other Identifiers

0000540373

11717708_s_at

11735790_x_at

11735791_a_at

127_at

160041_at

16885546

203555_PM_at

203555_at

213521_PM_at

213521_at

2505530

2505531

2505535

2505537

2505539

2505541

2505548

2505549

2505550

2505553

2505554

2505555

2505556

2505558

2505559

2505560

2505564

2505565

2505566

2505567

2505568

2505569

2505570

2505571

2505572

2505573

2505574

2505575

2505576

2505577

26469

33453_at

8045182

A_14_P201960

A_23_P210015

A_24_P80135

GE81921

GO:0001825

GO:0004721

GO:0004725

GO:0004726

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006470

GO:0016311

GO:0016787

GO:0016791

GO:0023052

GO:0035335

GO:0036211

GO:0043226

GO:0048856

GO:0140096

GO:1901185

HMNXSV003008453

HMNXSV003046228

Hs.6551.2.A1_3p_at

ILMN_1770005

PH_hs_0023069

TC02000809.hg

X79568_at

g7657483_3p_at

Participates

as an input of

PTPN18 binds ERBB2:EGFR heterodimers (Homo sapiens)

as a component of

Other forms of this molecule

PTPN18 [nucleoplasm]

Inferred To

Ghost homologue of PTPN18 [cytosol] (Caenorhabditis elegans)

Ghost homologue of PTPN18 [cytosol] (Canis familiaris)

Ghost homologue of PTPN18 [cytosol] (Gallus gallus)

PTPN18 [cytosol] (Bos taurus)

PTPN18 [cytosol] (Danio rerio)

PTPN18 [cytosol] (Mus musculus)

PTPN18 [cytosol] (Sus scrofa)

ptpn18 [cytosol] (Xenopus tropicalis)

Ptpn18 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001135842.1, NP_055184.2

OpenTargets

ENSG00000072135

HPA

ENSG00000072135-PTPN18

GeneCards

Q99952

Ensembl

ENST00000347849, ENSP00000310092, ENSP00000175756, ENSG00000072135, ENST00000175756

ZINC target

Q99952

PRO

Q99952

Pharos - Targets

Q99952

HMDB Protein

HMDBP08930

PDB

2OC3, 4GFV, 4NND, 4GFU

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.602	4
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.558	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2

Cite Us!