Reactome | PTPN18 [cytosol]

PTPN18 [cytosol]

Stable Identifier

R-HSA-8864101

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein phosphatase non-receptor type 18, BDP1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99952 PTPN18

Gene Names

PTPN18, BDP1

Chain

chain:1-460

Reference Genes

BioGPS Gene:26469 PTPN18

COSMIC (genes):BDP1 BDP1

COSMIC (genes):PTPN18 PTPN18

CTD Gene:26469 PTPN18

dbSNP Gene:26469 PTPN18

ENSEMBL:ENSG00000072135 PTPN18

HGNC:9649 PTPN18

KEGG:hsa:26469 PTPN18

Monarch:26469 PTPN18

NCBI Gene:26469 PTPN18

OMIM:606587 PTPN18

UCSC:Q99952 PTPN18

Reference Transcript

Participates

as an input of

PTPN18 binds ERBB2:EGFR heterodimers (Homo sapiens)

as a component of

Other forms of this molecule

PTPN18 [nucleoplasm]

Inferred To

Ghost homologue of PTPN18 [cytosol] (Caenorhabditis elegans)

Ghost homologue of PTPN18 [cytosol] (Canis familiaris)

Ghost homologue of PTPN18 [cytosol] (Drosophila melanogaster)

Ghost homologue of PTPN18 [cytosol] (Gallus gallus)

PTPN18 [cytosol] (Bos taurus)

PTPN18 [cytosol] (Mus musculus)

PTPN18 [cytosol] (Sus scrofa)

ptpn18 [cytosol] (Danio rerio)

ptpn18 [cytosol] (Xenopus tropicalis)

Ptpn18 [cytosol] (Rattus norvegicus)

Cross References

ENSEMBL

ENSP00000310092, ENSP00000175756, ENST00000175756, ENST00000347849, ENSG00000072135

OpenTargets

ENSG00000072135

IntEnz

3.1.3.48

GeneCards

PTPN18

HPA

ENSG00000072135-PTPN18

ZINC - Substances

PTN18_HUMAN

ZINC target

Q99952

PRO

Q99952

Pharos - Targets

Q99952

HMDB Protein

HMDBP08930

PDB

4GFV, 4GFU, 4NND, 2OC3

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.704	5
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.558	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2

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