Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Ub-C85-UBE2D1 [cytosol]
Stable Identifier
R-HSA-8864160
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UbcH5/Ubc4
Icon
Locations in the PathwayBrowser for interactor UniProt:Q6ZNA4 RNF111
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
MIB2 ubiquitinates CFLAR (Homo sapiens)
Ub-C85-UBE2D1 [cytosol] (Homo sapiens)
MIB2 ubiquitinates CYLD at K338, K530 (Homo sapiens)
Ub-C85-UBE2D1 [cytosol] (Homo sapiens)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)
Ub-C85-UBE2D1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51668 UBE2D1
Gene Names
UBE2D1, SFT, UBC5A, UBCH5, UBCH5A
Chain
chain:1-147
Reference Genes
BioGPS Gene:7321 UBE2D1
COSMIC (genes):UBE2D1 UBE2D1
CTD Gene:7321 UBE2D1
dbSNP Gene:7321 UBE2D1
ENSEMBL:ENSG00000072401 UBE2D1
ENSEMBL_homo_sapiens_GENE:ENSG00000072401.15 UBE2D1
HGNC:12474 UBE2D1
KEGG Gene (Homo sapiens):7321 UBE2D1
Monarch:7321 UBE2D1
NCBI Gene:7321 UBE2D1
OMIM:602961 UBE2D1
UCSC:P51668 UBE2D1
Reference Transcript
RefSeq:NM_003338.4 UBE2D1
Other Identifiers
1164_at
11723042_at
11723043_at
16705064
211764_PM_s_at
211764_s_at
214590_PM_s_at
214590_s_at
3247758
3247764
3247765
3247766
3247768
3247769
3247771
3247772
3247773
3247774
3247775
37826_at
7321
7927658
A_24_P13032
A_24_P364025
GE79396
GO:0000122
GO:0000151
GO:0000166
GO:0000209
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006511
GO:0016567
GO:0016740
GO:0019787
GO:0023052
GO:0030163
GO:0030514
GO:0031398
GO:0031625
GO:0032446
GO:0032991
GO:0036211
GO:0043161
GO:0043226
GO:0061630
GO:0061631
GO:0070936
GO:0140096
GO:1902916
GO:1904262
HMNXSV003032080
Hs.318435.0.S2_3p_s_at
ILMN_1787988
PH_hs_0007586
TC10000360.hg
g13543662_3p_s_at
Participates
as a member of
Ub-conjugated E2 enzyme (UBA6 substrate) [cytosol] (Homo sapiens)
Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Homo sapiens)
Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
as an output of
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)
MIB2 ubiquitinates CFLAR (Homo sapiens)
MIB2 ubiquitinates CYLD at K338, K530 (Homo sapiens)
as a component of
Ub:UBE2D1 [cytosol] (Homo sapiens)
Other forms of this molecule
UBE2D1 [cytosol]
UBE2D1 [nucleoplasm]
Inferred To
UBE2D1 [cytosol]
(Bos taurus)
UBE2D1 [cytosol]
(Canis familiaris)
UBE2D1 [cytosol]
(Sus scrofa)
ubc14 [cytosol]
(Schizosaccharomyces pombe)
ubc4 [cytosol]
(Schizosaccharomyces pombe)
Ub-C85-UBE2D1 [cytosol]
(Dictyostelium discoideum)
Ub-C85-UBE2D1 [cytosol]
(Gallus gallus)
Ub-C85-UBE2D1 [cytosol]
(Plasmodium falciparum)
Ghost homologue of Ub-C85-UBE2D1 [cytosol]
(Xenopus tropicalis)
UBC5 [cytosol]
(Saccharomyces cerevisiae)
ube2d1b [cytosol]
(Danio rerio)
Homologues of Ub-C85-UBE2D1 [cytosol]
(Dictyostelium discoideum)
Homologues of Ub-C85-UBE2D1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of Ub-C85-UBE2D1 [cytosol]
(Schizosaccharomyces pombe)
eff [cytosol]
(Drosophila melanogaster)
Ube2d1 [cytosol]
(Mus musculus)
Ube2d1 [cytosol]
(Rattus norvegicus)
UBC4 [cytosol]
(Saccharomyces cerevisiae)
let-70 [cytosol]
(Caenorhabditis elegans)
ubcB [cytosol]
(Dictyostelium discoideum)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 85
Coordinate
85
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_003329.1
Guide to Pharmacology - Targets
3228
OpenTargets
ENSG00000072401
GeneCards
P51668
HPA
ENSG00000072401-UBE2D1
Ensembl
ENSP00000363019
,
ENST00000373910
,
ENSG00000072401
PRO
P51668
Pharos - Targets
P51668
HMDB Protein
HMDBP00572
PDB
3OJ4
,
7ZJ3
,
5FER
,
3PTF
,
4QPL
,
4AP4
,
2YHO
,
2C4P
,
6D4P
,
5TUT
Interactors (50)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96FW1 OTUB1
2
OTUB1 [cytosol]
(R-HSA-933411)
OTUB1 [nucleoplasm]
(R-HSA-6783242)
0.851
15
UniProt:Q9Y4L5 RNF115
1
RNF115 [cytosol]
(R-HSA-8850904)
0.83
12
UniProt:Q9BV68 RNF126
1
RNF126 [cytosol]
(R-HSA-8851642)
0.817
7
UniProt:Q96BH1 RNF25
1
RNF25 [cytosol]
(R-HSA-975976)
0.801
6
UniProt:Q9HCM9 TRIM39
1
TRIM39 [cytosol]
(R-HSA-5688971)
0.8
6
UniProt:Q99942 RNF5
1
RNF5 [endoplasmic reticulum membrane]
(R-HSA-975990)
0.795
10
UniProt:Q9Y3C5 RNF11
0.788
9
UniProt:Q8ND25 ZNRF1
1
ZNRF1 [cytosol]
(R-HSA-8850903)
0.788
9
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.782
6
UniProt:O15344 MID1
1
MID1 [cytosol]
(R-HSA-976027)
0.781
7
UniProt:Q86UW9 DTX2
1
DTX2 [cytosol]
(R-HSA-1604436)
0.781
7
UniProt:Q6ZNA4 RNF111
2
RNF111 [cytosol]
(R-HSA-975981)
RNF111 [nucleoplasm]
(R-HSA-2186765)
0.742
5
UniProt:Q9UJV3-2 MID2
0.718
6
UniProt:Q9H000 MKRN2
0.718
6
UniProt:Q13064 MKRN3
0.666
4
UniProt:Q96GF1 RNF185
1
RNF185 [endoplasmic reticulum membrane]
(R-HSA-8861819)
0.666
4
UniProt:Q9P0P0 RNF181
1
RNF181 [cytoplasm]
(R-HSA-8939317)
0.666
4
UniProt:Q9UBS8 RNF14
1
RNF14 [cytosol]
(R-HSA-5688974)
0.666
4
UniProt:Q8N9I9 DTX3
0.666
6
UniProt:Q99496 RNF2
1
RNF2 [nucleoplasm]
(R-HSA-389119)
0.666
4
UniProt:Q06587 RING1
1
RING1 [nucleoplasm]
(R-HSA-389113)
0.666
6
UniProt:Q9BZR9 TRIM8
1
TRIM8 [cytosol]
(R-HSA-5624332)
0.666
4
IntAct:EBI-4399559 UBIQ
0.623
3
UniProt:Q8N5U6 RNF10
0.621
3
UniProt:Q9Y508 RNF114
1
RNF114 [cytosol]
(R-HSA-8850894)
0.621
3
UniProt:Q9CZW6
1
RNF146 [cytosol]
(R-MMU-3640827)
0.558
2
UniProt:P62990 UBIQ
0.558
2
UniProt:Q9HCM9-2 TRIM39
0.556
5
UniProt:O75382 TRIM3
1
TRIM3 [cytosol]
(R-HSA-5624344)
0.556
3
UniProt:Q96EP1-2 CHFR
0.556
3
IntAct:EBI-23192465 CCSB ORF ID
0.556
3
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [cytosol]
(R-HSA-1181251)
0.556
3
IntAct:EBI-22462114 CCSB ORF ID
0.556
3
UniProt:Q9HAC8 UBTD1
0.556
3
UniProt:Q96B67 ARRD3
0.556
5
UniProt:Q8N6D2 RNF182
1
RNF182 [cytosol]
(R-HSA-976010)
0.556
3
UniProt:Q9UHC7 MKRN1
2
MKRN1 [cytosol]
(R-HSA-976042)
p-S109-MKRN1 [cytosol]
(R-HSA-8948758)
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q9BYV2 TRI54
0.556
3
UniProt:Q86XT4 TRIM50
1
TRIM50 [cytosol]
(R-HSA-5688976)
0.556
5
UniProt:Q9BVG3 TRIM62
1
TRIM62 [cytosol]
(R-HSA-5624340)
0.556
3
UniProt:P62879 GNB2
4
GNB2 [cytosol]
(R-HSA-6814421)
Partially folded GNB2 [cytosol]
(R-HSA-8850536)
Unfolded GNB2 [cytosol]
(R-HSA-6814202)
GNB2 [plasma membrane]
(R-HSA-164335)
0.556
3
UniProt:Q6PCD5 RFWD3
0.553
2
UniProt:Q9UKV5 AMFR
1
AMFR [endoplasmic reticulum membrane]
(R-HSA-975999)
0.553
2
UniProt:Q9NS56 TOPORS
2
monoSUMO1-K560-TOPORS [nucleoplasm]
(R-HSA-4551754)
TOPORS [nucleoplasm]
(R-HSA-2993791)
0.547
2
UniProt:O88846
1
RNF4 [cytosol]
(R-RNO-975974)
0.544
4
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.527
2
UniProt:Q96EP1 CHFR
0.488
2
UniProt:Q9NZS9 BFAR
0.488
2
UniProt:Q86Y13 DZIP3
1
DZIP3 [cytosol]
(R-HSA-976002)
0.488
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text