Reactome | Ub-C92-UBE2K [cytosol]

Ub-C92-UBE2K [cytosol]

Stable Identifier

R-HSA-8864200

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin-conjugating enzyme E2 K, UBE2K_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)
        
        Ub:E2 (UBA1 substrate) [cytosol] (Homo sapiens)
        
        Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Homo sapiens)
        
        Ub-C92-UBE2K [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61086 UBE2K

Gene Names

UBE2K, HIP2, LIG

Chain

initiator methionine:, chain:2-200

Reference Genes

BioGPS Gene:3093 UBE2K

COSMIC (genes):UBE2K UBE2K

CTD Gene:3093 UBE2K

dbSNP Gene:3093 UBE2K

ENSEMBL:ENSG00000078140 UBE2K

ENSEMBL_homo_sapiens_GENE:ENSG00000078140.14 UBE2K

HGNC:4914 UBE2K

KEGG Gene (Homo sapiens):3093 UBE2K

Monarch:3093 UBE2K

NCBI Gene:3093 UBE2K

OMIM:602846 UBE2K

UCSC:P61086 UBE2K

Reference Transcript

Other Identifiers

11740529_s_at

11743413_a_at

11743414_a_at

11751186_a_at

11756717_a_at

16966173

202346_PM_at

202346_at

202347_PM_s_at

202347_s_at

225179_PM_at

225179_at

2724473

2724474

2724475

2724476

2724477

2724488

2724493

2724495

2724506

2724509

2724511

2724512

2724513

2724514

2724515

2724516

2724523

3093

40121_at

8094704

A_14_P119799

A_23_P155677

A_24_P277456

A_24_P286013

GE56503

GE79406

GO:0000166

GO:0000209

GO:0002376

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0006511

GO:0010800

GO:0010994

GO:0016567

GO:0016740

GO:0019787

GO:0023052

GO:0030163

GO:0031625

GO:0032433

GO:0032434

GO:0032446

GO:0034450

GO:0035458

GO:0036211

GO:0043161

GO:0043226

GO:0060340

GO:0061631

GO:0065003

GO:0070936

GO:0098542

GO:0140096

GO:1903265

HMNXSV003044538

Hs.7822.0.S1_3p_at

ILMN_1782954

ILMN_2174702

PH_hs_0023212

PH_hs_0035719

TC04000237.hg

U58522_at

g12545382_3p_at

g4996607_3p_a_at

Participates

as a member of

Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Homo sapiens)

Other forms of this molecule

UBE2K [cytosol]

Inferred To

Ube2k [cytosol] (Mus musculus)

Ube2k [cytosol] (Rattus norvegicus)

UBC1 [cytosol] (Saccharomyces cerevisiae)

Ubc4 [cytosol] (Drosophila melanogaster)

ubc-20 [cytosol] (Caenorhabditis elegans)

Ub-C92-UBE2K [cytosol] (Plasmodium falciparum)

ube2ka [cytosol] (Danio rerio)

UBE2K [cytosol] (Bos taurus)

UBE2K [cytosol] (Canis familiaris)

UBE2K [cytosol] (Gallus gallus)

UBE2K [cytosol] (Sus scrofa)

ubc1 [cytosol] (Schizosaccharomyces pombe)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 92

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_005330.1, NP_001104583.1, NP_001104582.1

OpenTargets

ENSG00000078140

HPA

ENSG00000078140-UBE2K

GeneCards

P61086

Ensembl

ENSP00000421203, ENST00000503368, ENST00000445950, ENSP00000390483, ENST00000261427, ENSG00000078140, ENSP00000261427

PRO

P61086

Pharos - Targets

P61086

HMDB Protein

HMDBP11993

PDB

3F92, 6IF1, 1YLA, 7MYH, 7OJX, 6JB6, 5DFL, 3K9P, 2O25, 3K9O, 6JB7, 7MYF, 3E46

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.805	12
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.742	24
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.666	4
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:Q9NX09 DDIT4	1	DDIT4 [cytosol] (R-HSA-5632374)	0.556	3
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [specific granule membrane] (R-HSA-6799631) LAMTOR1 [lysosomal membrane] (R-HSA-5653582) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003)	0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) TP53BP1 [nucleoplasm] (R-HSA-61175)	0.556	3
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.556	3
UniProt:Q7L8L6 FASTKD5	1	FASTKD5 [mitochondrial matrix] (R-HSA-9837206)	0.556	3
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3

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