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Ub-C86-UBE2L3 [cytosol]
Stable Identifier
R-HSA-8864201
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ubiquitin-conjugating enzyme E2 L3, UB2L3_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O95376 ARIH2
Expand all
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
ITCH polyubiquitinates MLKL at K50 (Homo sapiens)
Ub-C86-UBE2L3 [cytosol] (Homo sapiens)
PRKN polyubiquitinates RIPK3 (Homo sapiens)
Ub-C86-UBE2L3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
LUBAC ubiquitinates CFLAR at K351, K353 (Homo sapiens)
Ub-C86-UBE2L3 [cytosol] (Homo sapiens)
LUBAC ubiquitinates RIPK1 at K627 (Homo sapiens)
Ub-C86-UBE2L3 [cytosol] (Homo sapiens)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Homo sapiens)
Ub-C86-UBE2L3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P68036 UBE2L3
Gene Names
UBE2L3, UBCE7, UBCH7
Chain
chain:1-154
Reference Genes
BioGPS Gene:7332 UBE2L3
COSMIC (genes):UBE2L3 UBE2L3
CTD Gene:7332 UBE2L3
dbSNP Gene:7332 UBE2L3
ENSEMBL:ENSG00000185651 UBE2L3
ENSEMBL_homo_sapiens_GENE:ENSG00000185651.16 UBE2L3
HGNC:12488 UBE2L3
KEGG Gene (Homo sapiens):7332 UBE2L3
Monarch:7332 UBE2L3
NCBI Gene:7332 UBE2L3
OMIM:603721 UBE2L3
UCSC:P68036 UBE2L3
Reference Transcript
RefSeq:NM_001256356.1 UBE2L3
RefSeq:NM_003347.3 UBE2L3
RefSeq:NM_001256355.1 UBE2L3
Other Identifiers
11718509_s_at
11718510_a_at
11718511_s_at
11749192_s_at
11749193_x_at
11754929_s_at
16927615
200676_PM_s_at
200676_s_at
200682_PM_s_at
200682_s_at
200683_PM_s_at
200683_s_at
200684_PM_s_at
200684_s_at
223_at
3483952
3483953
3536774
3536775
3536776
3536777
3820148
38701_at
3938176
3938177
3938183
3938188
3938197
3938198
3938199
3938200
3938201
3938202
3938203
3938204
3938205
3938206
3938207
64361_s_at
7332
7968331
8071547
A_21_P0000566
A_23_P166353
GE55131
GO:0000151
GO:0000166
GO:0000209
GO:0003713
GO:0003723
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006511
GO:0006886
GO:0007005
GO:0008283
GO:0016567
GO:0016740
GO:0019787
GO:0019899
GO:0030163
GO:0031398
GO:0031625
GO:0032446
GO:0036211
GO:0043226
GO:0044770
GO:0045893
GO:0051443
GO:0061631
GO:0070979
GO:0071383
GO:0071385
GO:0097027
GO:0098772
GO:0140096
GO:0140110
GO:1903955
HMNXSV003027099
Hs.108104.0.S1_3p_a_at
Hs.108104.0.S2_3p_a_at
Hs.108104.0.S3_3p_a_at
ILMN_1677877
PH_hs_0029083
S81003_at
TC22000092.hg
TC22000993.hg
g4507788_3p_x_at
Participates
as a member of
Ub-conjugated E2 enzyme (UBA6 substrate) [cytosol] (Homo sapiens)
Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Homo sapiens)
Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Homo sapiens)
as an output of
LUBAC ubiquitinates CFLAR at K351, K353 (Homo sapiens)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Homo sapiens)
LUBAC ubiquitinates RIPK1 at K627 (Homo sapiens)
PRKN polyubiquitinates RIPK3 (Homo sapiens)
ITCH polyubiquitinates MLKL at K50 (Homo sapiens)
as a component of
Ub:UBE2L3 [cytosol] (Homo sapiens)
Other forms of this molecule
Ub-C86-UBE2L3 [nucleoplasm]
UBE2L3 [nucleoplasm]
UBE2L3 [cytosol]
Inferred To
Ub-C86-UBE2L3 [cytosol]
(Dictyostelium discoideum)
Ub-C86-UBE2L3 [cytosol]
(Gallus gallus)
ube2l3a [cytosol]
(Danio rerio)
ube2l3 [cytosol]
(Xenopus tropicalis)
Ubc10 [cytosol]
(Drosophila melanogaster)
Ube2l3 [cytosol]
(Mus musculus)
Ube2l3 [cytosol]
(Rattus norvegicus)
UBE2L3 [cytosol]
(Bos taurus)
UBE2L3 [cytosol]
(Canis familiaris)
UBE2L3 [cytosol]
(Sus scrofa)
ubc-18 [cytosol]
(Caenorhabditis elegans)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 86
Coordinate
86
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_001243285.1
,
NP_003338.1
,
NP_001243284.1
OpenTargets
ENSG00000185651
IntEnz
2.3.2.23
HPA
ENSG00000185651-UBE2L3
GeneCards
P68036
Ensembl
ENST00000342192
,
ENSG00000185651
,
ENST00000458578
,
ENST00000545681
,
ENSP00000445931
,
ENSP00000400906
,
ENSP00000344259
PRO
P68036
Pharos - Targets
P68036
Orphanet
22424
HMDB Protein
HMDBP00601
PDB
7B5N
,
6DJX
,
6N13
,
6CP2
,
6DJW
,
7B5L
,
5TTE
,
4Q5E
,
5HPT
,
7OIK
,
4Q5H
,
3SQV
,
5UDH
,
8EAZ
,
3SY2
,
1FBV
,
7V8F
,
1C4Z
,
8EB0
,
6XXU
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95376 ARIH2
1
ARIH2 [cytosol]
(R-HSA-975987)
0.884
12
UniProt:O15344 MID1
1
MID1 [cytosol]
(R-HSA-976027)
0.666
4
UniProt:P50876 RNF144A
1
RNF144A [endosome membrane]
(R-HSA-8938771)
0.666
4
UniProt:Q9BYM8 RBCK1
1
RBCK1 [cytosol]
(R-HSA-976018)
0.666
4
UniProt:Q9Y4X5 ARIH1
1
ARIH1 [cytosol]
(R-HSA-1678825)
0.643
7
UniProt:Q99PZ6 OSPG
0.558
3
UniProt:Q8N6D2 RNF182
1
RNF182 [cytosol]
(R-HSA-976010)
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
IntAct:EBI-23192465 CCSB ORF ID
0.556
3
UniProt:O60260-5 PRKN
0.556
3
UniProt:Q9NWF9 RNF216
1
RNF216 [cytosol]
(R-HSA-936043)
0.556
3
UniProt:O94941 UBOX5
1
UBOX5 [cytosol]
(R-HSA-976034)
0.547
2
UniProt:Q6ZMZ0 RNF19B
1
RNF19B [cytosol]
(R-HSA-975969)
0.524
2
UniProt:Q96EQ8 RNF125
2
RNF125 [cytosol]
(R-HSA-918184)
K48polyUb-RNF125 [cytosol]
(R-HSA-3080560)
0.488
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
6
UniProt:Q9NPC3 CIP1
0.482
2
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