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Ub-C145-UBE2E3 [nucleoplasm]
Stable Identifier
R-HSA-8864208
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ubiquitin-conjugating enzyme E2 E3 ecNumber evidence="8"2.3.2.23/ecNumber, UB2E3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
Ub:E2 (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Ub-C145-UBE2E3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q969T4 UBE2E3
Gene Names
UBE2E3, UBCE4, UBCH9
Chain
initiator methionine:, chain:2-207
Reference Genes
BioGPS Gene:10477 UBE2E3
COSMIC (genes):UBE2E3 UBE2E3
CTD Gene:10477 UBE2E3
dbSNP Gene:10477 UBE2E3
ENSEMBL:ENSG00000170035 UBE2E3
ENSEMBL_homo_sapiens_GENE:ENSG00000170035.16 UBE2E3
HGNC:12479 UBE2E3
KEGG Gene (Homo sapiens):10477 UBE2E3
Monarch:10477 UBE2E3
NCBI Gene:10477 UBE2E3
OMIM:604151 UBE2E3
UCSC:Q969T4 UBE2E3
Reference Transcript
RefSeq:NM_001278555.1 UBE2E3
RefSeq:NM_182678.2 UBE2E3
RefSeq:NM_001278554.1 UBE2E3
RefSeq:NM_006357.3 UBE2E3
RefSeq:XM_005246244.2 UBE2E3
Other Identifiers
10477
11742138_a_at
11742946_s_at
16888232
210024_PM_s_at
210024_s_at
2518164
2518165
2518166
2518167
2518168
2518169
2518172
2518196
2518198
2518199
2518200
2518201
2518202
34850_at
3969607
3969608
8046685
A_23_P11192
A_24_P148450
A_33_P3223713
GE61012
GO:0000166
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0016567
GO:0016740
GO:0019787
GO:0032446
GO:0036211
GO:0043226
GO:0061631
GO:0070534
GO:0070936
GO:0070979
GO:0140096
HMNXSV003005459
ILMN_1669553
ILMN_1708463
ILMN_1765714
ILMN_1809652
ILMN_2390338
g4586929_3p_a_at
Participates
as a member of
Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
UBE2E3 [cytosol]
UBE2E3 [nucleoplasm]
Ub-C145-UBE2E3 [cytosol]
Inferred To
Ube2e3 [nucleoplasm]
(Mus musculus)
Ube2e3 [nucleoplasm]
(Rattus norvegicus)
Dmel\CG2574 [nucleoplasm]
(Drosophila melanogaster)
Ub-C145-UBE2E3 [nucleoplasm]
(Dictyostelium discoideum)
Ub-C145-UBE2E3 [nucleoplasm]
(Gallus gallus)
Ub-C145-UBE2E3 [nucleoplasm]
(Sus scrofa)
UBE2E3 [nucleoplasm]
(Bos taurus)
UBE2E3 [nucleoplasm]
(Canis familiaris)
ube2e3 [nucleoplasm]
(Danio rerio)
ube2e3 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 145
Coordinate
145
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_872619.1
,
XP_005246301.1
,
NP_006348.1
,
NP_001265483.1
,
NP_001265484.1
OpenTargets
ENSG00000170035
IntEnz
2.3.2.23
GeneCards
Q969T4
HPA
ENSG00000170035-UBE2E3
Ensembl
ENSP00000376215
,
ENSP00000473623
,
ENST00000602710
,
ENST00000410062
,
ENSP00000386788
,
ENST00000392415
,
ENSG00000170035
,
ENSP00000473639
,
ENST00000602959
PRO
Q969T4
Pharos - Targets
Q969T4
HMDB Protein
HMDBP00593
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q6ZNA4 RNF111
2
RNF111 [cytosol]
(R-HSA-975981)
RNF111 [nucleoplasm]
(R-HSA-2186765)
0.553
2
UniProt:Q96NR8 RDH12
6
RDH12 [photoreceptor inner segment membrane]
(R-HSA-2464787)
RDH12 Ala269Glyfs*2 [photoreceptor inner segment membrane]
(R-HSA-2471748)
RDH12 H151N [photoreceptor inner segment membrane]
(R-HSA-2471751)
RDH12 Y226C [photoreceptor inner segment membrane]
(R-HSA-2471697)
RDH12 Q189* [photoreceptor inner segment membrane]
(R-HSA-2471667)
RDH12 A126V [photoreceptor inner segment membrane]
(R-HSA-2471753)
0.527
2
UniProt:Q9NS56 TOPORS
2
monoSUMO1-K560-TOPORS [nucleoplasm]
(R-HSA-4551754)
TOPORS [nucleoplasm]
(R-HSA-2993791)
0.527
2
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.527
2
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