Reactome: A Curated Pathway Database

AP-2 (TFAP2) transcription factors form homo- and heterodimers

Stable Identifier
R-HSA-8864278
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

AP-2 family transcription factors (TFAP2) bind palindromic DNA response elements as dimers. AP-2 family members are able to form homo- and heterodimers through the interaction of their C-terminal helix-span-helix (HSH) motifs. Both HSH motifs and centrally located basic regions are needed for DNA binding (Williams and Tjian 1991a, Williams and Tjian 1991b).

Literature References
Participants
Participant Of
Orthologous Events