Reactome | TFAP2A [nucleoplasm]

TFAP2A [nucleoplasm]

Stable Identifier

R-HSA-8864280

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor AP-2-alpha, AP2-alpha, AP-2, AP2TF, Activator protein 2

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        Positive Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        RB1 and TFAP2A bind CDH1 gene promoter (Homo sapiens)
        
        RB1:TFAP2A homodimer:CDH1 gene [nucleoplasm] (Homo sapiens)
        
        TFAP2A homodimer [nucleoplasm] (Homo sapiens)
        
        TFAP2A [nucleoplasm] (Homo sapiens)
        
        TFAP2A homodimer [nucleoplasm] (Homo sapiens)
        
        TFAP2A [nucleoplasm] (Homo sapiens)
        
        RB1 and TFAP2A stimulate CDH1 gene transcription (Homo sapiens)
        
        RB1:TFAP2A homodimer:CDH1 gene [nucleoplasm] (Homo sapiens)
        
        TFAP2A homodimer [nucleoplasm] (Homo sapiens)
        
        TFAP2A [nucleoplasm] (Homo sapiens)
        
        TFAP2A homodimer [nucleoplasm] (Homo sapiens)
        
        TFAP2A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P05549 TFAP2A

Gene Names

TFAP2A, AP2TF, TFAP2

Chain

chain:1-437

Reference Genes

BioGPS Gene:7020 TFAP2A

COSMIC (genes):TFAP2A TFAP2A

CTD Gene:7020 TFAP2A

dbSNP Gene:7020 TFAP2A

ENSEMBL:ENSG00000137203 TFAP2A

HGNC:11742 TFAP2A

KEGG:hsa:7020 TFAP2A

Monarch:7020 TFAP2A

NCBI Gene:7020 TFAP2A

OMIM:107580 TFAP2A

UCSC:P05549 TFAP2A

Reference Transcript

Participates

as a protein marker of

embryonic non-neural surface ectoderm cell (Homo sapiens)

as an input of

as a component of

as an output of

Expression of TFAP2A in the neural plate border (Homo sapiens)

as a member of

This entity regulates

Positively

Expression of ZIC1 in the neural plate border (Homo sapiens)

Inferred To

aptf-2 [nucleoplasm] (Caenorhabditis elegans)

tfap2a [nucleoplasm] (Xenopus tropicalis)

aptf-1 [nucleoplasm] (Caenorhabditis elegans)

TfAP-2 [nucleoplasm] (Drosophila melanogaster)

Tfap2a [nucleoplasm] (Mus musculus)

Tfap2a [nucleoplasm] (Rattus norvegicus)

TFAP2A [nucleoplasm] (Bos taurus)

TFAP2A [nucleoplasm] (Canis familiaris)

TFAP2A [nucleoplasm] (Gallus gallus)

TFAP2A [nucleoplasm] (Sus scrofa)

aptf-4 [nucleoplasm] (Caenorhabditis elegans)

Homologues of TFAP2A [nucleoplasm] (Caenorhabditis elegans)

aptf-3 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001027451.1, NP_001035890.1, NP_003211.1

ENSEMBL

ENSP00000368928, ENST00000319516, ENSG00000137203, ENST00000379608, ENSP00000316516

OpenTargets

ENSG00000137203

GeneCards

TFAP2A

HPA

ENSG00000137203-TFAP2A

PRO

P05549

Pharos - Targets

P05549

GlyGen

P05549

Orphanet

TFAP2A

PDB

8J0R, 8J0L, 8J0K

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4Y5 GSTO2	1	GSTO2 [cytosol] (R-HSA-176066)	0.666	4
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342)	0.646	4
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.591	6
UniProt:Q86TX2 ACOT1	1	ACOT1 [cytosol] (R-HSA-2066771)	0.564	2
UniProt:Q13064 MKRN3			0.556	3
UniProt:P06429 VE7			0.553	2
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.508	7
UniProt:P61244 MAX	1	MAX [nucleoplasm] (R-HSA-3006627)	0.499	2

Cite Us!