TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP

Stable Identifier
R-HSA-8864307
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Transcriptional co-factors from the CITED family interact with the helix-span-helix (HSH) domain of TFAP2 (AP-2) family of transcription factors and recruit transcription co-activators EP300 (p300) and CREBBP (CBP) to TFAP2-bound DNA elements. CITED2 shows the highest affinity for TFAP2 proteins, followed by CITED4, while CITED1 interacts with TFAP2s with a very low affinity. The interaction with CITED proteins was specifically demonstrated for TFAP2A (AP-2 alpha), TFAP2B (AP2-beta) and TFAP2C (AP-2 gamma), and is extrapolated to TFAP2D (AP2-delta) and TFAP2E (AP-2 epsilon) based on sequence similarity (Braganca et al. 2002, Braganca et al. 2003). Mouse embryos defective for CITED2 exhibit neural crest defects, cardiac malformations and adrenal agenesis, which can at least in part be attributed to defective Tfap2 transactivation (Bamforth et al. 2001).

Literature References
PubMed ID Title Journal Year
11694877 Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator

Bamforth, SD, Braganša, J, Eloranta, JJ, Murdoch, JN, Marques, FI, Kranc, KR, Farza, H, Henderson, DJ, Hurst, HC, Bhattacharya, S

Nat. Genet. 2001
11744733 Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2

Braganša, J, Swingler, T, Marques, FI, Jones, T, Eloranta, JJ, Hurst, HC, Shioda, T, Bhattacharya, S

J. Biol. Chem. 2002
12586840 Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2

Braganša, J, Eloranta, JJ, Bamforth, SD, Ibbitt, JC, Hurst, HC, Bhattacharya, S

J. Biol. Chem. 2003
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