Reactome | KCTD15 [nucleoplasm]

KCTD15 [nucleoplasm]

Stable Identifier

R-HSA-8864337

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BTB/POZ domain-containing protein KCTD15, KCD15_HUMAN, Potassium channel tetramerization domain-containing protein 15

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
      - Negative regulation of activity of TFAP2 (AP-2) family transcription factors (Homo sapiens)
        
        KCTD15 binds TFAP2 homo- and heterodimers (Homo sapiens)
        
        KCTD15 [nucleoplasm] (Homo sapiens)
        
        TFAP2 homo- and heterodimers:KCTD15 [nucleoplasm] (Homo sapiens)
        
        KCTD15 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96SI1 KCTD15

Gene Names

KCTD15

Chain

chain:1-283

Reference Genes

BioGPS Gene:79047 KCTD15

COSMIC (genes):KCTD15 KCTD15

CTD Gene:79047 KCTD15

dbSNP Gene:79047 KCTD15

ENSEMBL:ENSG00000153885 KCTD15

HGNC:23297 KCTD15

KEGG:hsa:79047 KCTD15

Monarch:79047 KCTD15

NCBI Gene:79047 KCTD15

OMIM:615240 KCTD15

UCSC:Q96SI1 KCTD15

Reference Transcript

Participates

as a component of

TFAP2 homo- and heterodimers:KCTD15 [nucleoplasm] (Homo sapiens)

as an input of

KCTD15 binds TFAP2 homo- and heterodimers (Homo sapiens)

Cross References

RefSeq

XP_047295349.1, XP_011525598.2, XP_054178056.1, XP_054178057.1, XP_054178054.1, XP_054178055.1, XP_016882772.1, XP_047295350.1, XP_047295356.1, XP_047295358.1, XP_047295357.1, XP_047295355.1, XP_054178046.1, XP_054178045.1, XP_054178049.1, XP_054178044.1, XP_047295354.1, XP_054178048.1, XP_047295352.1, XP_011525598.1, XP_054178047.1, XP_047295353.1, XP_047295351.1, XP_011525599.1, NP_076981.2, XP_011525600.1, NP_001123467.1, NP_001123466.1, XP_054178053.1, XP_054178052.1, XP_054178051.1, XP_054178050.1

OpenTargets

ENSG00000153885

ENSEMBL

ENST00000683859, ENST00000284006, ENSP00000464812, ENSP00000467612, ENSP00000508199, ENSP00000394390, ENST00000430256, ENSP00000284006, ENST00000589786, ENSG00000153885, ENST00000588881

HPA

ENSG00000153885-KCTD15

GeneCards

KCTD15

PRO

Q96SI1

Pharos - Targets

Q96SI1

PDB

8PNR, 8PNM

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.643	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.556	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	2
UniProt:Q6ZMB5 T184A			0.527	2
UniProt:Q86UA1 PRP39			0.527	2
UniProt:Q9NS85 CAH10			0.527	2
UniProt:Q96SI1 KCTD15	1	KCTD15 [nucleoplasm] (R-HSA-8864337)	0.522	2

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