Reactome | KCTD1 [nucleoplasm]

KCTD1 [nucleoplasm]

Stable Identifier

R-HSA-8864339

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BTB/POZ domain-containing protein KCTD1, KCTD1_HUMAN, Potassium channel tetramerization domain-containing protein 1, C18orf5

Locations in the PathwayBrowser for interactor UniProt:P25786 PSMA1

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
      - Negative regulation of activity of TFAP2 (AP-2) family transcription factors (Homo sapiens)
        
        KCTD1 binds TFAP2 homo- and heterodimers (Homo sapiens)
        
        KCTD1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q719H9 KCTD1

Gene Names

KCTD1, C18orf5

Chain

chain:1-257

Reference Genes

BioGPS Gene:284252 KCTD1

COSMIC (genes):KCTD1 KCTD1

CTD Gene:284252 KCTD1

dbSNP Gene:284252 KCTD1

ENSEMBL:ENSG00000134504 KCTD1

HGNC:18249 KCTD1

KEGG Gene (Homo sapiens):284252 KCTD1

Monarch:284252 KCTD1

NCBI Gene:284252 KCTD1

OMIM:613420 KCTD1

UCSC:Q719H9 KCTD1

Reference Transcript

Other Identifiers

11749548_a_at

16854397

226245_at

226246_at

284252

3178385

3802255

3802256

3802257

3802258

3802259

3802264

3802274

3802280

3802311

3802312

3802313

3802326

44113_at

47324_at

8022646

A_23_P130343

A_23_P130352

GE502887

GE88395

GO:0000122

GO:0003674

GO:0003714

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005815

GO:0005829

GO:0005856

GO:0008134

GO:0008150

GO:0009058

GO:0022607

GO:0034451

GO:0034641

GO:0042802

GO:0043226

GO:0045171

GO:0045892

GO:0051260

GO:0065003

HMNXSV003026088

HMNXSV003049567

Hs.289088.1.A1_3p_at

Hs.289088.1.A2_3p_at

ILMN_1759984

PH_hs_0020135

TC18000426.hg

Participates

as a component of

TFAP2 homo- and heterodimers:KCTD1 [nucleoplasm] (Homo sapiens)

as an input of

KCTD1 binds TFAP2 homo- and heterodimers (Homo sapiens)

Inferred To

Kctd1 [nucleoplasm] (Mus musculus)

Kctd1 [nucleoplasm] (Rattus norvegicus)

KCTD1 [nucleoplasm] (Bos taurus)

KCTD1 [nucleoplasm] (Canis familiaris)

KCTD1 [nucleoplasm] (Gallus gallus)

KCTD1 [nucleoplasm] (Sus scrofa)

kctd1 [nucleoplasm] (Danio rerio)

kctd1 [nucleoplasm] (Xenopus tropicalis)

twz [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001129677.1, NP_945342.1, XP_016881197.1, NP_001136202.1, NP_001245150.1

OpenTargets

ENSG00000134504

GeneCards

Q719H9

HPA

ENSG00000134504-KCTD1

Ensembl

ENSG00000134504, ENSP00000464170, ENST00000417602, ENSP00000408405, ENST00000579973, ENST00000408011, ENSP00000314831, ENST00000317932, ENSP00000384367

PRO

Q719H9

Pharos - Targets

Q719H9

Orphanet

22029

PDB

5BXB, 5BXD, 6S4L

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.781	7
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.772	6
UniProt:Q9Y3B2 EXOSC1	2	EXOSC1 [nucleoplasm] (R-HSA-6791578) EXOSC1 [cytosol] (R-HSA-429841)	0.718	6
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.718	6
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.718	6
UniProt:Q96HA8 NTAQ1			0.666	4
UniProt:Q7L775 EPMIP			0.556	3
UniProt:P57075-2 UBASH3A			0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:P24278 ZBT25			0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.556	3
UniProt:Q8TAP4 LMO3			0.556	3
UniProt:P0DI81-3 TRAPPC2			0.556	3
UniProt:Q15014 MORF4L2	1	MORF4L2 [nucleoplasm] (R-HSA-3322945)	0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q96SI1-2 KCTD15			0.556	6
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.556	3
UniProt:Q96PF1 TGM7			0.556	3
UniProt:P0DI81 TRAPPC2	1	TRAPPC2 [cytosol] (R-HSA-5683757)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:Q96SI1 KCTD15	1	KCTD15 [nucleoplasm] (R-HSA-8864337)	0.556	3
UniProt:P03346 GAG			0.488	2

Cite Us!