Reactome | KCTD1 binds TFAP2 homo- and heterodimers

KCTD1 binds TFAP2 homo- and heterodimers

Stable Identifier

R-HSA-8864343

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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KCTD1 binds TFAP2 homo- and heterodimers

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The BTB domain at the N-terminus of KCTD1 binds to the N-terminal transactivation domain of TFAP2 (AP-2) family transcription factors. Binding of KCTD1 to TFAP2A, TFAP2B and TFAP2C inhibits their transcriptional activity, thus acting as a negative regulator (Ding et al. 2009). Based on sequence similarity, KCTD1 is assumed to interact with TFAP2D and TFAP2E.

Literature References

PubMed ID	Title	Journal	Year
19115315	The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation Zhang, J, He, A, Ding, X, Zhou, J, Ren, K, Luo, C, Hu, X, Zhou, F, Zhu, J, Gan, L, Zhong, Y, Gao, X	J. Cell. Biochem.	2009