TFAP2A,TFAP2C homodimers bind ESR1 promoter

Stable Identifier
R-HSA-8864381
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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AP-2 family transcription factors TFAP2A (AP-2 alpha) and TFAP2C (AP-2 gamma) bind to the TFAP2 consensus in the promoter of the estrogen receptor alpha (ESR1). It has not been tested whether heterodimers of TFAP2A and TFAP2C or only their respective homodimers can bind to the ESR1 promoter (McPherson and Weigel 1999). The presence of CITED proteins CITED2, CITED4 and CITED1, which act as TFAP2 co-activators, has not been examined at the ESR1 promoter but is plausible.

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