TFAP2A,TFAP2C homodimers bind the CGB gene promoter

Stable Identifier
R-HSA-8864426
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The CGB (chorionic gonadotropin beta) gene promoter, similar to CGA (chorionic gonadotropin alpha) gene promoter, contains several putative AP-2 transcription factor binding sites. TFAP2A (AP-2 alpha) and TFAP2C (AP-2 gamma), which are both expressed in the placenta, can both bind to the CGB promoter (Johnson et al. 1997, LiCalsi et al. 2000). It has not been examined whether TFAP2A and TFAP2C bind the CGB promoter as homodimers or heterodimers and if CITED family members are involved in TFAP2A/C-mediated transactivation of CGB transcription.

Literature References
PubMed ID Title Journal Year
10648798 AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin

LiCalsi, C, Christophe, S, Steger, DJ, Buescher, M, Fischer, W, Mellon, PL

Nucleic Acids Res. 2000
9182571 Regulation of the human chorionic gonadotropin alpha- and beta-subunit promoters by AP-2

Johnson, W, Albanese, C, Handwerger, S, Williams, T, Pestell, RG, Jameson, JL

J. Biol. Chem. 1997
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