TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers bind the ERBB2 gene promoter and recruit YY1

Stable Identifier
R-HSA-8864453
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Homodimers and heterodimers of AP-2 family transcription factors TFAP2A (AP-2 alpha), TFAP2B (AP-2 beta) and TFAP2C (AP-2 gamma) can bind to AP-2 response elements in the ERBB2 gene promoter (Bosher et al. 1996). TFAP2A forms a complex with YY1 (Ying Yang 1) transcription factor and recruits it to the ERBB2 promoter (Begon et al. 2005). Interaction of YY1 with TFAP2B and TFAP2C has not been examined but is plausible based on sequence similarity.

Literature References
PubMed ID Title Journal Year
8895516 A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma

Bosher, JM, Totty, NF, Hsuan, JJ, Williams, T, Hurst, HC

Oncogene 1996
15870067 Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells

Begon, DY, Delacroix, L, Vernimmen, D, Jackers, P, Winkler, R

J. Biol. Chem. 2005
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