TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression

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Reaction [omitted]
Homo sapiens
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Binding of AP-2 transcription factors TFAP2A (AP-2 alpha), TFAP2B (AP-2 beta) and TFAP2C (AP-2 gamma) to AP-2 response elements in the ERBB2 gene promoter stimulates ERBB2 transcription, with TFAP2B having the weakest effect (Bosher et al. 1996). Association of YY1 transcription factor with TFAP2A (and, possibly, TFAP2B and TFAP2C) significantly increases the ERBB2 gene transcription rate (Begon et al. 2005).

Literature References
PubMed ID Title Journal Year
8895516 A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma

Bosher, JM, Totty, NF, Hsuan, JJ, Williams, T, Hurst, HC

Oncogene 1996
15870067 Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells

Begon, DY, Delacroix, L, Vernimmen, D, Jackers, P, Winkler, R

J. Biol. Chem. 2005
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