WWOX binds TFAP2C

Stable Identifier
R-HSA-8864569
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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WWOX binds TFAP2C
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The tumor suppressor WWOX associates with TFAP2C (AP-2 gamma) in the cytosol and prevents TFAP2C nuclear translocation and TFAP2C-mediated transcription. WWOX is also able to bind to TFAP2A, but the biological role of this interaction has not been examined (Aqeilan et al. 2004). Low levels of WWOX and high levels of TFAP2C are associated with tamoxifen resistance in breast cancer (Guler et al. 2007).
Literature References
PubMed ID Title Journal Year
15548692 Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor

Weigel, RJ, Palamarchuk, A, Herrero, JJ, Aqeilan, RI, Croce, CM, Pekarsky, Y

Cancer Res. 2004
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Orthologous Events
WWOX binds TFAP2C (Bos taurus)
WWOX binds TFAP2C (Caenorhabditis elegans)
WWOX binds TFAP2C (Canis familiaris)
WWOX binds TFAP2C (Danio rerio)
WWOX binds TFAP2C (Drosophila melanogaster)
WWOX binds TFAP2C (Gallus gallus)
WWOX binds TFAP2C (Mus musculus)
WWOX binds TFAP2C (Rattus norvegicus)
WWOX binds TFAP2C (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Zarelli, VE  (2016-05-04)
Bogachek, MV  (2016-05-17)
Dawid, IB  (2016-05-04)
Weigel, RJ  (2016-05-17)
Created
Orlic-Milacic, M  (2016-03-16)
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