TFAP2A,(TFAP2B) homodimers bind the KIT gene promoter

Stable Identifier
R-HSA-8864690
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The gene encoding KIT receptor tyrosine kinase contains two AP-2 binding sites in its promoter. AP-2 (TFAP2) transcription factor family members TFAP2A (AP-2 alpha) and TFAP2B (AP-2 beta) can bind these sites most likely as homodimers (Huang et al. 1998). The role of TFAP2B in KIT gene regulation has been studied in less detail than the role of TFAP2A.

Literature References
PubMed ID Title Journal Year
9687504 Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis

Huang, S, Jean, D, Luca, M, Tainsky, MA, Bar-Eli, M

EMBO J. 1998
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