PITX2 gene expression is stimulated by TFAP2A,TFAP2C homodimers:CITED2

Stable Identifier
R-HSA-8864729
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PITX2 gene expression is stimulated by TFAP2A,TFAP2C homodimers:CITED2
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The PITX2 gene encodes a homeobox transcription factor involved in left-right patterning and heart development. The PITX2 gene expression is stimulated by binding of the complex of CITED2 and TFAP2A or TFAP2C homodimers to the AP-2 response elements in the PITX2 promoter (Bamforth et al. 2004, Li et al. 2012).
Literature References
PubMed ID Title Journal Year
15475956 Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway

Anderson, RH, Bhattacharya, S, Farthing, CR, Broadbent, C, Neubauer, S, Bragança, J, Clarke, K, Bamforth, SD, Schneider, JE, Michell, AC, Norris, D, Brown, NA

Nat. Genet. 2004
22735262 CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression

Pan, H, Guan, L, Li, Q, Su, D, Ma, X

Biochem. Biophys. Res. Commun. 2012
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TFAP2A,TFAP2C homodimers:CITED2:PITX2 Gene [nucleoplasm] (Homo sapiens)
Active Unit
TFAP2A,TFAP2C homodimers:CITED2 [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Zarelli, VE  (2016-05-04)
Bogachek, MV  (2016-05-17)
Dawid, IB  (2016-05-04)
Weigel, RJ  (2016-05-17)
Created
Orlic-Milacic, M  (2016-03-16)
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