SETD6 methylates RELA in the NFkB complex

Stable Identifier
R-HSA-8865237
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SET domain containing 6 (SETD6) is an N-lysine methyltransferase that monomethylates the RelA subunit of nuclear factor kappa B (NF-kB) at Lys-310 (Levy et al. 2011, Chang et al. 2011).

Literature References
PubMed ID Title Journal Year
21131967 Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

Levy, D, Kuo, AJ, Chang, Y, Schaefer, U, Kitson, C, Cheung, P, Espejo, A, Zee, BM, Liu, CL, Tangsombatvisit, S, Tennen, RI, Kuo, AY, Tanjing, S, Cheung, R, Chua, KF, Utz, PJ, Shi, X, Prinjha, RK, Lee, K, Garcia, BA, Bedford, MT, Tarakhovsky, A, Cheng, X, Gozani, O

Nat. Immunol. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein-lysine N-methyltransferase activity of SETD6 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created
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