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TFAP2C homodimer:MYC:KDM5B [nucleoplasm]
Stable Identifier
R-HSA-8865263
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of cell cycle factors (Homo sapiens)
CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B:CDKN1A gene [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm] (Homo sapiens)
TFAP2C homodimer binds MYC and KDM5B (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm] (Homo sapiens)
TFAP2C homodimer binds the CDKN1A (p21) gene promoter (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B:CDKN1A gene [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
22371483
Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A)
Berlato, C
,
Hurst, HC
,
Miranda, F
,
Wong, PP
,
Scibetta, AG
,
Chan, KV
Mol. Cell. Biol.
2012
Participants
components
KDM5B [nucleoplasm]
(Homo sapiens)
MYC [nucleoplasm]
(Homo sapiens)
TFAP2C homodimer [nucleoplasm]
(Homo sapiens)
Participates
as a component of
TFAP2C homodimer:MYC:KDM5B:CDKN1A gene [nucleoplasm] (Homo sapiens)
as an input of
TFAP2C homodimer binds the CDKN1A (p21) gene promoter (Homo sapiens)
as an output of
TFAP2C homodimer binds MYC and KDM5B (Homo sapiens)
Inferred To
TFAP2C homodimer:MYC:KDM5B [nucleoplasm]
(Bos taurus)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm]
(Canis familiaris)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm]
(Danio rerio)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm]
(Drosophila melanogaster)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm]
(Gallus gallus)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm]
(Mus musculus)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm]
(Rattus norvegicus)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm]
(Sus scrofa)
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