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RUNX1 [nucleoplasm]
Stable Identifier
R-HSA-8865295
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Runt-related transcription factor 1, AML1, Oncogene AML-1, Acute myeloid leukemia 1 protein, Core-binding factor subunit alpha-2, CBF-alpha-2, CBFA2, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit, RUNX1_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9H2X6 HIPK2
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)
RUNX1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 3b binds to RUNX1 (Homo sapiens)
RUNX1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
Regulation of RUNX1 Expression and Activity (Homo sapiens)
CBFB binds RUNX1 (Homo sapiens)
RUNX1 [nucleoplasm] (Homo sapiens)
CCND3,(CCND1,CCND2) binds RUNX1 (Homo sapiens)
RUNX1 [nucleoplasm] (Homo sapiens)
PML binds RUNX1 (Homo sapiens)
RUNX1 [nucleoplasm] (Homo sapiens)
PTPN11 dephosphorylates RUNX1 (Homo sapiens)
RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1 binds SRC (Homo sapiens)
RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 (Homo sapiens)
RUNX1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Transcription and Translation (Homo sapiens)
RUNX1 binds NOTCH4 gene (Homo sapiens)
RUNX1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01196 RUNX1
Gene Names
RUNX1, AML1, CBFA2
Chain
chain:1-453
Reference Genes
COSMIC (genes):RUNX1 RUNX1
dbSNP Gene:861 RUNX1
ENSEMBL:ENSG00000159216 RUNX1
Participates
as a component of
CEBPA gene:RUNX1:SPI1:GATA2:TAL1:FLI1:MYB [nucleoplasm] (Homo sapiens)
RUNX1:3b [nucleoplasm] (Homo sapiens)
RUNX1:Cbfb [nucleoplasm] (Homo sapiens)
RUNX1:PML [nucleoplasm] (Homo sapiens)
p-Y419-SRC:RUNX1 [nucleoplasm] (Homo sapiens)
RUNX1:CCND3,(CCND1,CCND2) [nucleoplasm] (Homo sapiens)
RUNX1:CBFB [nucleoplasm] (Homo sapiens)
RUNX1:NOTCH4 gene [nucleoplasm] (Homo sapiens)
as an input of
RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)
SARS-CoV-1 3b binds to RUNX1 (Homo sapiens)
CCND3,(CCND1,CCND2) binds RUNX1 (Homo sapiens)
PML binds RUNX1 (Homo sapiens)
RUNX1 binds SRC (Homo sapiens)
CBFB binds RUNX1 (Homo sapiens)
RUNX1 binds NOTCH4 gene (Homo sapiens)
as an output of
PTPN11 dephosphorylates RUNX1 (Homo sapiens)
RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 (Homo sapiens)
as a member of
RUNX1,RUNX1:CBFB [nucleoplasm] (Homo sapiens)
Other forms of this molecule
RUNX1 [plasma membrane]
p-S249,S273,S276-RUNX1 [nucleoplasm]
p-7Y-RUNX1 [nucleoplasm]
MeR206,MeR210-RUNX1 [nucleoplasm]
Inferred To
run [nucleoplasm]
(Drosophila melanogaster)
RUNX1 [nucleoplasm]
(Bos taurus)
RUNX1 [nucleoplasm]
(Caenorhabditis elegans)
RUNX1 [nucleoplasm]
(Canis familiaris)
RUNX1 [nucleoplasm]
(Danio rerio)
RUNX1 [nucleoplasm]
(Gallus gallus)
RUNX1 [nucleoplasm]
(Mus musculus)
RUNX1 [nucleoplasm]
(Rattus norvegicus)
RUNX1 [nucleoplasm]
(Sus scrofa)
RUNX1 [nucleoplasm]
(Xenopus tropicalis)
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13951 CBFB
1
CBFB [nucleoplasm]
(R-HSA-8865293)
0.872
7
UniProt:Q9H2X6 HIPK2
3
p-HIPK2 [nucleoplasm]
(R-HSA-6799375)
HIPK2 [nucleoplasm]
(R-HSA-3215222)
monoSUMO1-K32-HIPK2 [nucleoplasm]
(R-HSA-4090405)
0.639
4
UniProt:Q00534 CDK6
3
p-T177-CDK6 [nucleoplasm]
(R-HSA-69628)
CDK6 [nucleoplasm]
(R-HSA-141283)
CDK6 [cytosol]
(R-HSA-68336)
0.628
5
UniProt:P17542 TAL1
1
TAL1 [nucleoplasm]
(R-HSA-8956511)
0.623
3
UniProt:Q15723 ELF2
1
ELF2 [nucleoplasm]
(R-HSA-8938898)
0.544
2
UniProt:Q9GZV5 WWTR1
3
WWTR1 [nucleoplasm]
(R-HSA-1629775)
WWTR1 [cytosol]
(R-HSA-1629773)
p-S89-WWTR1 [cytosol]
(R-HSA-2028665)
0.527
2
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