RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene

Stable Identifier
R-HSA-8865491
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RUNX1 recruits histone methyltransferase KMT2A (MLL) to the SPI1 (PU.1) gene locus (Huang et al. 2011). This interaction was demonstrated by using endogenous mouse proteins and DNA, as well as by expressing recombinant human KMT2A and RUNX1 in mouse myeloid progenitor cell line 416B.

Literature References
PubMed ID Title Journal Year
22012064 The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Huang, G, Zhao, X, Wang, L, Elf, S, Xu, H, Zhao, X, Sashida, G, Zhang, Y, Liu, Y, Lee, J, Menendez, S, Yang, Y, Yan, X, Zhang, P, Tenen, DG, Osato, M, Hsieh, JJ, Nimer, SD

Blood 2011
Participants
Participant Of
Inferred From
Authored
Reviewed
Created