KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark

Stable Identifier
R-HSA-8865498
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Once recruited to the SPI1 (PU.1) gene locus, KMT2A (MLL) histone methyltransferase trimethylates nucleosomes associated with the SPI1 promoter and the upstream regulatory element. KMT2A creates the H3K4Me3 mark on histone H3 at the SPI1 gene, a characteristic of transcriptionally active chromatin (Huang et al. 2011).

Literature References
PubMed ID Title Journal Year
22012064 The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Huang, G, Zhao, X, Wang, L, Elf, S, Xu, H, Zhao, X, Sashida, G, Zhang, Y, Liu, Y, Lee, J, Menendez, S, Yang, Y, Yan, X, Zhang, P, Tenen, DG, Osato, M, Hsieh, JJ, Nimer, SD

Blood 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone methyltransferase activity (H3-K4 specific) of RUNX1:CBFB:KMT2A:SPI1 gene:Nucleosome [nucleoplasm]
Physical Entity
Activity
Inferred From
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Reviewed
Created