SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A

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R-HSA-8865505
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Reaction [omitted]
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Homo sapiens
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The SPI1 (PU.1) transcription factor represses self renewal and proliferation of HSCs (Fukuchi et al. 2008) and is needed for commitment of HSCs to specific hematopoietic lineages (Imperato et al. 2015), for example differentiation of lymphoid cells. SPI1 gene transcription is directly stimulated by the RUNX1:CBFB transcription factor complex, in the presence of the activating histone methyltransferase KMT2A (MLL) (Huang et al. 2011).

Literature References
PubMed ID Title Journal Year
22012064 The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Huang, G, Zhao, X, Wang, L, Elf, S, Xu, H, Zhao, X, Sashida, G, Zhang, Y, Liu, Y, Lee, J, Menendez, S, Yang, Y, Yan, X, Zhang, P, Tenen, DG, Osato, M, Hsieh, JJ, Nimer, SD

Blood 2011
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