Reactome | ZRSR2 [nucleoplasm]

ZRSR2 [nucleoplasm]

Stable Identifier

R-HSA-8865914

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2, U2AFM_HUMAN

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
21041408	The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing Zheng, X, Shen, H, Luecke, S, Green, MR	Genes Dev.	2010
25586593	Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome Kohlmann, A, Miyano, S, Grossmann, V, Sundaresan, J, Ganser, A, Thol, F, Li, J, Yang, H, Madan, V, Haferlach, T, Shiraishi, Y, Ogawa, S, Sanada, M, Sato-Otsubo, A, Koeffler, HP, Okamoto, R, Kanojia, D	Nat Commun	2015

External Reference Information

External Reference

UniProt:Q15696 ZRSR2

Gene Names

ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2, URP

Chain

chain:1-482

Reference Genes

BioGPS Gene:8233 ZRSR2

COSMIC (genes):ZRSR2 ZRSR2

CTD Gene:8233 ZRSR2

dbSNP Gene:8233 ZRSR2

ENSEMBL:ENSG00000169249.14 ZRSR2

HGNC:23019 ZRSR2

KEGG Gene (Homo sapiens):8233 ZRSR2

Monarch:8233 ZRSR2

NCBI Gene:8233 ZRSR2

OMIM:300028 ZRSR2

UCSC:Q15696 ZRSR2

Reference Transcript

RefSeq:NM_005089.3 ZRSR2

Other Identifiers

0001410347

11758542_x_at

208174_3p_x_at

208174_PM_x_at

208174_x_at

213876_3p_x_at

213876_PM_x_at

213876_x_at

2824319

2824320

2824321

2824322

2824324

35060_at

38523_f_at

3969948

3969950

3969953

3969956

3969957

3969960

3969963

3969968

3969969

3969970

3969971

3969973

3969974

3969975

3969976

8166195

8233

D49677_at

GE57231

GO:0000245

GO:0000398

GO:0003674

GO:0003676

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005681

GO:0005689

GO:0006397

GO:0008150

GO:0008380

GO:0016071

GO:0030628

GO:0032991

GO:0042802

GO:0043167

GO:0043226

GO:0046872

GO:0065003

GO:0089701

HMNXSV003034635

Hs.171909.1.S1_3p_a_at

ILMN_1773868

ILMN_1797537

ILMN_3247732

TC0X000072.hg

g13186299_3p_s_at

g4827045_3p_a_at

Participates

as a component of

as an input of

Formation of AT-AC A complex (Homo sapiens)

Inferred To

Dmel\CG3294 [nucleoplasm] (Drosophila melanogaster)

ZRSR2 [nucleoplasm] (Bos taurus)

ZRSR2 [nucleoplasm] (Canis familiaris)

ZRSR2 [nucleoplasm] (Danio rerio)

ZRSR2 [nucleoplasm] (Gallus gallus)

ZRSR2 [nucleoplasm] (Sus scrofa)

zrsr2 [nucleoplasm] (Danio rerio)

zrsr2 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of ZRSR2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of ZRSR2 [nucleoplasm] (Danio rerio)

Zrsr2 [nucleoplasm] (Mus musculus)

Zrsr2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_005080.1

OpenTargets

ENSG00000169249

GeneCards

Q15696

HPA

ENSG00000169249-ZRSR2

Ensembl

ENSG00000169249, ENST00000307771, ENSP00000303015

PRO

Q15696

Pharos - Targets

Q15696

Orphanet

25058

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.788	7
UniProt:Q9H190 SDCB2			0.781	7
UniProt:P49760 CLK2			0.718	8
UniProt:Q15695 U2AFL			0.666	4
UniProt:Q96SB4 SRPK1	1	SRPK1 [cytosol] (R-HSA-9729349)	0.59	2
UniProt:Q8WVP5 TNFAIP8L1	1	TNFAIP8L1 [cytosol] (R-HSA-8874482)	0.556	3
UniProt:Q9Y2D8 ADIP			0.556	3
UniProt:Q7Z7F0-4 KHDC4			0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:Q6BDI9 REP15			0.556	3
UniProt:A7MD48 SRRM4			0.556	3
UniProt:Q15696 ZRSR2	1	ZRSR2 [nucleoplasm] (R-HSA-8865914)	0.556	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
UniProt:Q13243 SRSF5	1	SRSF5 [nucleoplasm] (R-HSA-72028)	0.556	3
UniProt:Q9Y383 LC7L2			0.556	3
UniProt:Q9UK58 CCNL1			0.556	3