Reactome | SF1 [nucleoplasm]

SF1 [nucleoplasm]

Stable Identifier

R-HSA-8865928

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Splicing factor 1, SF01_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P26368 U2AF2

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External Reference Information

External Reference

UniProt:Q15637 SF1

Gene Names

SF1, ZFM1, ZNF162

Chain

initiator methionine:, chain:2-639

Reference Genes

BioGPS Gene:7536 SF1

COSMIC (genes):SF1 NR5A1

CTD Gene:7536 SF1

dbSNP Gene:7536 SF1

ENSEMBL:ENSG00000168066 SF1

HGNC:12950 SF1

KEGG:hsa:7536 SF1

Monarch:7536 SF1

NCBI Gene:7536 SF1

OMIM:601516 SF1

UCSC:Q15637 SF1

Reference Transcript

Participates

as an input of

Formation of the Spliceosomal E complex (Homo sapiens)

as an output of

Formation of the Spliceosomal A complex (Homo sapiens)

as a component of

Spliceosomal E complex [nucleoplasm] (Homo sapiens)

Inferred To

Ghost homologue of SF1 [nucleoplasm] (Gallus gallus)

sf1 [nucleoplasm] (Xenopus tropicalis)

sfa-1 [nucleoplasm] (Caenorhabditis elegans)

Sf1 [nucleoplasm] (Mus musculus)

Sf1 [nucleoplasm] (Rattus norvegicus)

SF1 [nucleoplasm] (Bos taurus)

SF1 [nucleoplasm] (Canis familiaris)

SF1 [nucleoplasm] (Drosophila melanogaster)

SF1 [nucleoplasm] (Sus scrofa)

Cross References

OpenTargets

ENSG00000168066

ENSEMBL

ENSP00000366611, ENST00000377390, ENST00000377394, ENST00000377387, ENSG00000168066, ENSP00000334414, ENSP00000396793, ENSP00000227503, ENST00000334944, ENST00000433274, ENST00000227503, ENSP00000366604, ENSP00000366607

HPA

ENSG00000168066-SF1

GeneCards

SF1

PRO

Q15637

Pharos - Targets

Q15637

GlyGen

Q15637

PDB

2M09, 4FXW, 1K1G, 7VPX, 1O0P, 7VH9, 8PXX, 2M0G, 1OPI, 4FXX

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26368 U2AF2	2	U2AF2 [nucleoplasm] (R-HSA-71987) 5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011)	0.948	23
UniProt:Q96I25 RBM17	1	RBM17 [nucleoplasm] (R-HSA-8865891)	0.73	8
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.709	8
UniProt:Q92841 DDX17	2	DDX17 [nucleoplasm] (R-HSA-3900090) monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.668	4
UniProt:Q92567 F168A			0.666	4
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.582	6
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.564	2
UniProt:O76071 CIAO1	1	CIAO1 [cytosol] (R-HSA-2161126)	0.556	3
UniProt:Q6PEX3 KRTAP26-1	1	KRTAP26-1 [cytosol] (R-HSA-6810244)	0.556	3
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.556	3
UniProt:Q86WT6 TRIM69	1	TRIM69 [cytosol] (R-HSA-5688977)	0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q93062 RBPMS			0.553	2
UniProt:P54253 ATX1			0.547	2
UniProt:Q15637 SF1	1	SF1 [nucleoplasm] (R-HSA-8865928)	0.547	3
UniProt:O75400 PRPF40A	1	PRPF40A [nucleoplasm] (R-HSA-8867890)	0.482	3

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