MET activates PTPN11

Stable Identifier
R-HSA-8865999
Type
Pathway
Species
Homo sapiens
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Summation

PTPN11 (SHP2), recruited to activated MET receptor through GAB1, is phosphorylated in response to HGF treatment, although phosphorylation sites and direct MET involvement have not been examined (Schaeper et al. 2000, Duan et al. 2006). Phosphorylation of PTPN11 in response to HGF treatment is required for the recruitment and activation of sphingosine kinase SPHK1, which may play a role in HGF-induced cell scattering (Duan et al. 2006). While PTPN11 promotes MAPK3/1 (ERK1/2) signaling downstream of MET, it can also dephosphorylate MET on unidentified tyrosine residues (Furcht et al. 2014).

Literature References
PubMed ID Title Journal Year
16765027 Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts

Duan, HF, Qu, CK, Zhang, QW, Yu, WM, Wang, H, Wu, CT, Wang, LS

Cell. Signal. 2006
10871282 Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

Schaeper, U, Gehring, NH, Fuchs, KP, Sachs, M, Kempkes, B, Birchmeier, W

J. Cell Biol. 2000
24951116 Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells

Furcht, CM, Buonato, JM, Skuli, N, Mathew, LK, Muņoz Rojas, AR, Simon, MC, Lazzara, MJ

J. Cell. Sci. 2014
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