Reactome | UBQLN1 [cytosol]

UBQLN1 [cytosol]

Stable Identifier

R-HSA-8866006

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquilin-1, UBQL1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UMX0 UBQLN1

Gene Names

UBQLN1, DA41, PLIC1

Chain

initiator methionine:1, chain:2-589

Reference Genes

BioGPS Gene:29979 UBQLN1

COSMIC (genes):UBQLN1 UBQLN1

CTD Gene:29979 UBQLN1

dbSNP Gene:29979 UBQLN1

ENSEMBL:ENSG00000135018 UBQLN1

HGNC:12508 UBQLN1

KEGG Gene (Homo sapiens):29979 UBQLN1

Monarch:29979 UBQLN1

NCBI Gene:29979 UBQLN1

OMIM:605046 UBQLN1

UCSC:Q9UMX0 UBQLN1

Reference Transcript

Other Identifiers

0006100113

0006100278

11734016_s_at

11734017_a_at

11737138_a_at

17095248

222989_s_at

222990_at

222991_s_at

29979

2JY5

2JY6

2KLC

3212144

3212145

3212146

3212147

3212148

3212150

3212151

3212152

3212153

3212156

3212157

3212161

3212162

3212163

3212164

3212165

3212169

3212170

3212171

3212172

3212173

37256

46707_at

54143

57914_at

8161988

82573_at

A0A024R258

A_23_P250904

A_23_P250910

A_24_P329597

A_24_P329600

A_24_P338121

AAD49751

AAG02473

AAH10066

AAH39294

AB035275

AEE61129

AF176069

AF293384

AK074535

AL136643

AL354920

BAB20436

BC010066

BC039294

CAB037256

CAB66578

CCDS6663

CCDS6664

CH471089

EAW62659

EAW62661

EAW62663

EAW62664

ENSG00000135018

ENSP00000257468

ENSP00000365576

ENST00000257468

ENST00000257468.11

ENST00000376395

ENST00000376395.8

EntrezGene:29979

EntrezGene:UBQLN1

g12052811_3p_a_at

GE81838

GO:0000045

GO:0000502

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005773

GO:0005776

GO:0005783

GO:0005829

GO:0005886

GO:0006464

GO:0006511

GO:0006810

GO:0006914

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0009056

GO:0016020

GO:0016235

GO:0016236

GO:0016241

GO:0019899

GO:0019900

GO:0022607

GO:0030433

GO:0031396

GO:0031398

GO:0031410

GO:0031593

GO:0032991

GO:0034140

GO:0034976

GO:0035973

GO:0042802

GO:0043226

GO:0048471

GO:0055085

GO:0071456

GO:0097352

GO:1901340

GO:1902175

GO:1903071

H0YDS0

HGNC:12508

HM005532

HPA054143

Hs.9589.0.A1_3p_a_at

Hs.9589.0.A3_3p_at

ILMN_1688622

ILMN_1798380

ILMN_2351611

IPR000626

IPR006636

IPR009060

IPR015496

IPR015940

IPR028799

IPR029071

MIM:605046

NM_013438

NM_053067

NP_038466

NP_444295

PF00240

PF00627

PH_hs_0000988

SM00165

SM00213

SM00727

TC09001280.hg

UBQLN1

UBQLN1-201

UBQLN1-202

UPI0000038DA1

UPI000013E45A

XM_005251948

XP_005252005

Participant Of

hasCandidate

UBQLN2,1 [cytosol]

Inferred To

UBQLN1 [cytosol] (Bos taurus)

UBQLN1 [cytosol] (Caenorhabditis elegans)

UBQLN1 [cytosol] (Canis familiaris)

UBQLN1 [cytosol] (Dictyostelium discoideum)

UBQLN1 [cytosol] (Drosophila melanogaster)

UBQLN1 [cytosol] (Gallus gallus)

UBQLN1 [cytosol] (Mus musculus)

UBQLN1 [cytosol] (Plasmodium falciparum)

UBQLN1 [cytosol] (Rattus norvegicus)

UBQLN1 [cytosol] (Saccharomyces cerevisiae)

UBQLN1 [cytosol] (Schizosaccharomyces pombe)

UBQLN1 [cytosol] (Sus scrofa)

UBQLN1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_444295.1, NP_038466.2

OpenTargets

ENSG00000135018

GeneCards

Q9UMX0

PRO

Q9UMX0

PDB

2JY6, 2KLC, 2JY5

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TCZ2 CD99L2	1	CD99L2 [plasma membrane] (R-HSA-8867207)	0.718	6
UniProt:O75084 FZD7	1	FZD7 [plasma membrane] (R-HSA-517394)	0.712	4
UniProt:Q9NUQ2 AGPAT5	2	AGPAT5 [endoplasmic reticulum membrane] (R-HSA-61811) AGPAT5 [mitochondrial outer membrane] (R-HSA-1500585)	0.696	5
UniProt:P04155 TFF1	1	TFF1 [extracellular region] (R-HSA-9017879)	0.621	3
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.592	4
UniProt:P01160 NPPA	5	NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(26-55) [extracellular region] (R-HSA-5578794) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-153) [extracellular region] (R-HSA-976950)	0.556	3
UniProt:P42566 EPS15	2	EPS15 [cytosol] (R-HSA-182920) p-Y850 EPS15 [cytosol] (R-HSA-8867028)	0.556	5
UniProt:P05121 SERPINE1	4	SERPINE1 [platelet alpha granule lumen] (R-HSA-114649) SERPINE1 [plasma membrane] (R-HSA-158922) SERPINE1 [extracellular region] (R-HSA-158797) SERPINE1 [extracellular region] (R-HSA-61271)	0.556	3
UniProt:P02751 FN1	8	FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.556	3
UniProt:P12318 FCGR2A	3	FCGR2A [plasma membrane] (R-HSA-197838) FCGR2A [secretory granule membrane] (R-HSA-6804791) p-Y288,Y304-FCGR2A [plasma membrane] (R-HSA-2029069)	0.556	3
UniProt:Q8IW45 NAXD	1	CARKD [mitochondrial matrix] (R-HSA-6806970)	0.556	3
UniProt:Q6ISS4 LAIR2	1	LAIR2 [extracellular region] (R-HSA-5696342)	0.488	2
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.488	2
UniProt:O94888 UBXN7	1	UBXN7 [cytosol] (R-HSA-8956071)	0.488	2
UniProt:Q969H8 MYDGF	1	C19orf10 [endoplasmic reticulum lumen] (R-HSA-535584)	0.488	2
UniProt:Q09472 EP300	5	Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.488	2
UniProt:P55056 APOC4	1	APOC4 [extracellular region] (R-HSA-5215930)	0.488	2
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.488	2
UniProt:P62987 UBA52	39	Ub-33-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783187) UBA52(1-76) [endocytic vesicle membrane] (R-HSA-939236) Ub-63-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783039) Ub-6-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783072) Ub-11-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783059) Ub-48-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783049) Ub-29-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783030) Ub-27-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783043) N6-glycyl-L-lysine-UBA52(1-76) [cytosol] (R-HSA-8869043) Ub-29-UBA52(1-76) [cytosol] (R-HSA-5689209) Ub-6-UBA52(1-76) [cytosol] (R-HSA-5689082) Ub-33-UBA52(1-76) [cytosol] (R-HSA-5689141) adenylatedG76-UBA52(1-76) [nucleoplasm] (R-HSA-8852114) UBA52(1-128) [cytosol] (R-HSA-8853517) adenylatedG76-UBA52(1-76) [cytosol] (R-HSA-8852112) Ub-48-UBA52(1-76) [endoplasmic reticulum membrane] (R-HSA-8943067) UBA52(1-76) [endoplasmic reticulum membrane] (R-HSA-8943092) UBA52(1-76) [plasma membrane] (R-HSA-3149452) UBA52(1-76) [endosome membrane] (R-HSA-939189) RPL40 [cytosol] (R-HSA-72476) Ub-27-UBA52(1-76) [cytosol] (R-HSA-5689174) Ub-11-UBA52(1-76) [cytosol] (R-HSA-3095931) Ub-63-UBA52(1-76) [endosome membrane] (R-HSA-939185) Ub-63-UBA52(1-76) [plasma membrane] (R-HSA-939851) Ub-27-UBA52(1-76) [nucleoplasm] (R-HSA-6782610) Ub-29-UBA52(1-76) [nucleoplasm] (R-HSA-6782612) Ub-63-UBA52(1-76) [nucleoplasm] (R-HSA-6782530) Ub-48-UBA52(1-76) [nucleoplasm] (R-HSA-6782481) Ub-11-UBA52(1-76) [nucleoplasm] (R-HSA-6782647) Ub-33-UBA52(1-76) [nucleoplasm] (R-HSA-6782658) Ub-6-UBA52(1-76) [nucleoplasm] (R-HSA-6782616) UBA52(1-76) [nucleoplasm] (R-HSA-939844) Ub-48-UBA52(1-76) [nucleoplasm] (R-HSA-5683034) Ub-63-UBA52(1-76) [nucleoplasm] (R-HSA-5682838) UBA52(1-76) [late endosome lumen] (R-HSA-9660003) Ub-48-UBA52(1-76) [cytosol] (R-HSA-939250) UBA52(1-76) [cytosol] (R-HSA-939203) UBA52(1-76) [lysosomal lumen] (R-HSA-9660000) Ub-63-UBA52(1-76) [cytosol] (R-HSA-939169)	0.488	2
UniProt:P62979 RPS27A	40	RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-27-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783176) N6-glycyl-L-lysine-RPS27A(1-76) [cytosol] (R-HSA-8869045) Ub-29-RPS27A(1-76) [cytosol] (R-HSA-5689223) Ub-6-RPS27A(1-76) [cytosol] (R-HSA-5689098) Ub-33-RPS27A(1-76) [cytosol] (R-HSA-5689170) adenylatedlG76-RPS27A(1-76) [nucleoplasm] (R-HSA-8852078) RPS27A [cytosol] (R-HSA-8853524) adenylatedlG76-RPS27A(1-76) [cytosol] (R-HSA-8852065) Ub-48-RPS27A(1-76) [endoplasmic reticulum membrane] (R-HSA-8943102) RPS27A(1-76) [endoplasmic reticulum membrane] (R-HSA-8943127) RPS27A(1-76) [plasma membrane] (R-HSA-3149457) RPS27A(1-76) [endosome membrane] (R-HSA-939238) RPS27A(77-156) [cytosol] (R-HSA-72363) Ub-27-RPS27A(1-76) [cytosol] (R-HSA-5689154) Ub-11-RPS27A(1-76) [cytosol] (R-HSA-3095933) Ub-63-RPS27A(1-76) [endosome membrane] (R-HSA-939222) Ub-63-RPS27A(1-76) [plasma membrane] (R-HSA-939855) Ub-27-RPS27A(1-76) [nucleoplasm] (R-HSA-6782671) Ub-29-RPS27A(1-76) [nucleoplasm] (R-HSA-6782593) Ub-63-RPS27A(1-76) [nucleoplasm] (R-HSA-6782503) Ub-48-RPS27A(1-76) [nucleoplasm] (R-HSA-6782471) Ub-11-RPS27A(1-76) [nucleoplasm] (R-HSA-6782679) Ub-33-RPS27A(1-76) [nucleoplasm] (R-HSA-6782618) Ub-6-RPS27A(1-76) [nucleoplasm] (R-HSA-6782608) RPS27A(1-76) [nucleoplasm] (R-HSA-939849) Ub-48-RPS27A(1-76) [nucleoplasm] (R-HSA-5683037) Ub-63-RPS27A(1-76) [nucleoplasm] (R-HSA-5682849) RPS27A(1-76) [late endosome lumen] (R-HSA-9660022) Ub-48-RPS27A(1-76) [cytosol] (R-HSA-939202) RPS27A(1-76) [cytosol] (R-HSA-939205) RPS27A(1-76) [lysosomal lumen] (R-HSA-9660001) Ub-63-RPS27A(1-76) [cytosol] (R-HSA-939248)	0.488	2
UniProt:P22466 GAL	1	GAL [extracellular region] (R-HSA-389038)	0.488	2
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.488	2
UniProt:P08294 SOD3	3	SOD3 [extracellular region] (R-HSA-3299690) SOD3 (19-227) [extracellular region] (R-HSA-4837350) SOD3 [Golgi lumen] (R-HSA-3697878)	0.488	2