Reactome | UBQLN1 [cytosol]

UBQLN1 [cytosol]

Stable Identifier

R-HSA-8866006

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquilin-1, UBQL1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UMX0 UBQLN1

Gene Names

UBQLN1, DA41, PLIC1

Chain

initiator methionine:1, chain:2-589

Reference Genes

BioGPS Gene:29979 UBQLN1

COSMIC (genes):UBQLN1 UBQLN1

CTD Gene:29979 UBQLN1

dbSNP Gene:29979 UBQLN1

ENSEMBL:ENSG00000135018 UBQLN1

ENSEMBL:ENSG00000135018.14 UBQLN1

HGNC:12508 UBQLN1

KEGG Gene (Homo sapiens):29979 UBQLN1

Monarch:29979 UBQLN1

NCBI Gene:29979 UBQLN1

OMIM:605046 UBQLN1

UCSC:Q9UMX0 UBQLN1

Reference Transcript

Other Identifiers

11734016_s_at

11734017_a_at

11737138_a_at

17095248

222989_PM_s_at

222989_s_at

222990_PM_at

222990_at

222991_PM_s_at

222991_s_at

29979

3212144

3212145

3212146

3212147

3212148

3212150

3212151

3212152

3212153

3212156

3212157

3212161

3212162

3212163

3212164

3212165

3212169

3212170

3212171

3212172

3212173

46707_at

57914_at

8161988

82573_at

A_23_P250904

A_23_P250910

A_24_P329597

A_24_P329600

A_24_P338121

GE81838

GO:0000045

GO:0000502

GO:0002376

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005773

GO:0005776

GO:0005783

GO:0005829

GO:0005886

GO:0006914

GO:0012501

GO:0016020

GO:0016235

GO:0016236

GO:0016241

GO:0019900

GO:0023052

GO:0030163

GO:0030433

GO:0031396

GO:0031398

GO:0031410

GO:0031593

GO:0032434

GO:0032991

GO:0033554

GO:0034140

GO:0034976

GO:0035973

GO:0036211

GO:0042802

GO:0043226

GO:0048471

GO:0055085

GO:0071456

GO:0097352

GO:1901340

GO:1902175

GO:1903071

HMNXSV003034440

HMNXSV003041707

Hs.9589.0.A1_3p_a_at

Hs.9589.0.A3_3p_at

ILMN_1688622

ILMN_1798380

ILMN_2351611

PH_hs_0000988

TC09001280.hg

g12052811_3p_a_at

Participates

as a candidate of

UBQLN2,1 [cytosol] (Homo sapiens)

Inferred To

Dmel\CG31528 [cytosol] (Drosophila melanogaster)

UBQLN1 [cytosol] (Bos taurus)

UBQLN1 [cytosol] (Caenorhabditis elegans)

UBQLN1 [cytosol] (Gallus gallus)

UBQLN1 [cytosol] (Plasmodium falciparum)

UBQLN1 [cytosol] (Schizosaccharomyces pombe)

UBQLN1 [cytosol] (Sus scrofa)

Ubqn [cytosol] (Drosophila melanogaster)

Ubqln1 [cytosol] (Mus musculus)

Ubqln1 [cytosol] (Rattus norvegicus)

ubql-1 [cytosol] (Caenorhabditis elegans)

DSK2 [cytosol] (Saccharomyces cerevisiae)

ubqln [cytosol] (Dictyostelium discoideum)

Homologues of UBQLN1 [cytosol] (Caenorhabditis elegans)

Homologues of UBQLN1 [cytosol] (Drosophila melanogaster)

Homologues of UBQLN1 [cytosol] (Plasmodium falciparum)

Homologues of UBQLN1 [cytosol] (Schizosaccharomyces pombe)

ubqln1 [cytosol] (Xenopus tropicalis)

dph1 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_038466.2, NP_444295.1

OpenTargets

ENSG00000135018

GeneCards

Q9UMX0

HPA

ENSG00000135018-UBQLN1

Ensembl

ENSP00000257468, ENST00000376395, ENSG00000135018, ENSP00000365576, ENST00000257468

PRO

Q9UMX0

Pharos - Targets

Q9UMX0

PDB

2KLC, 2JY5, 2JY6

Interactors (57)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75084 FZD7	1	FZD7 [plasma membrane] (R-HSA-517394)	0.742	5
UniProt:Q9NUQ2 AGPAT5	2	AGPAT5 [mitochondrial outer membrane] (R-HSA-1500585) AGPAT5 [endoplasmic reticulum membrane] (R-HSA-61811)	0.718	6
UniProt:Q8TCZ2 CD99L2	1	CD99L2 [plasma membrane] (R-HSA-8867207)	0.718	6
UniProt:P08123 COL1A2	20	GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023602) 3x4Hyp-3Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023558) GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023547) 3x4Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023674) 3x4Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023580) 3x4Hyp-3Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023663) 3x4Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022070) 3x4Hyp-3Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022501) 3x4Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022977) 3x4Hyp-3Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022966) 5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022455) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396490) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396080) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396375) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396493) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396241) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396064) Dehydrolysinonorlysyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396361) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396431) Dehydrolysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396174)	0.718	6
UniProt:P04155 TFF1	1	TFF1 [extracellular region] (R-HSA-9017879)	0.666	6
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.592	4
UniProt:P0DTC6 6	4	6 [nuclear envelope] (R-COV-9727279) 6 [cytosol] (R-COV-9708916) 6 [endoplasmic reticulum membrane] (R-COV-9727295) 6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9705293)	0.556	3
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.556	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:Q8IW45 NAXD	1	CARKD [mitochondrial matrix] (R-HSA-6806970)	0.556	3
UniProt:Q8WUX9 CHMP7	2	CHMP7 [cytosol] (R-HSA-917703) CHMP7 [endosome membrane] (R-HSA-9631168)	0.556	3
UniProt:Q7Z7J5 DPPA2	1	DPPA2 [nucleoplasm] (R-HSA-9816401)	0.556	3
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.556	3
UniProt:Q8N3R9 PALS1	2	MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9689606) MPP5 [plasma membrane] (R-HSA-419969)	0.556	3
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.556	3
UniProt:Q86WV5 TEN1	1	TEN1 [nucleoplasm] (R-HSA-9668823)	0.556	3
UniProt:Q9BVC3 DSCC1	1	DSCC1 [nucleoplasm] (R-HSA-9668907)	0.556	3
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P21741 MDK	1	MDK [extracellular region] (R-HSA-2160953)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:P50553 ASCL1	1	ASCL1 [nucleoplasm] (R-HSA-212402)	0.556	3
UniProt:Q6ISS4 LAIR2	1	LAIR2 [extracellular region] (R-HSA-5696342)	0.556	3
UniProt:P02751 FN1	10	FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.556	3
UniProt:P22415 USF1	1	USF1 [nucleoplasm] (R-HSA-9023562)	0.556	3
UniProt:P22466 GAL	1	GAL [extracellular region] (R-HSA-389038)	0.556	3
UniProt:Q969H8 MYDGF	1	C19orf10 [endoplasmic reticulum lumen] (R-HSA-535584)	0.556	3
UniProt:O95947 TBX6	1	TBX6 [nucleoplasm] (R-HSA-9793377)	0.556	3
UniProt:P08294 SOD3	3	SOD3 [Golgi lumen] (R-HSA-3697878) SOD3 (19-227) [extracellular region] (R-HSA-4837350) SOD3 [extracellular region] (R-HSA-3299690)	0.556	3
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.556	3
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.556	3
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.556	5
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-27-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783176) N6-glycyl-L-lysine-RPS27A(1-76) [cytosol] (R-HSA-8869045) adenylatedlG76-RPS27A(1-76) [nucleoplasm] (R-HSA-8852078) RPS27A [cytosol] (R-HSA-8853524) adenylatedlG76-RPS27A(1-76) [cytosol] (R-HSA-8852065) Ub-48-RPS27A(1-76) [endoplasmic reticulum membrane] (R-HSA-8943102) Ub-48-RPS27A(1-76) [lysosomal membrane] (R-HSA-9763033) Ub-48-RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-9763012) RPS27A(1-76) [endosome membrane] (R-HSA-939238) RPS27A(1-76) [plasma membrane] (R-HSA-3149457) Ub-29-RPS27A(1-76) [cytosol] (R-HSA-5689223) Ub-6-RPS27A(1-76) [cytosol] (R-HSA-5689098)	0.556	3
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1(1-606)-RAF1(227-648) fusion [cytosol] (R-HSA-6802312) ESRP1 [nucleoplasm] (R-HSA-6803472) ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol] (R-HSA-6802523)	0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.556	3
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [lysosomal membrane] (R-HSA-5653582) LAMTOR1 [specific granule membrane] (R-HSA-6799631) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003)	0.556	3
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:P12318 FCGR2A	3	FCGR2A [secretory granule membrane] (R-HSA-6804791) FCGR2A [plasma membrane] (R-HSA-197838) p-Y288,Y304-FCGR2A [plasma membrane] (R-HSA-2029069)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	6
UniProt:P62987 UBA52	20	UBA52(1-76) [endocytic vesicle membrane] (R-HSA-939236) Ub-33-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783187) Ub-63-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783039) Ub-6-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783072) Ub-11-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783059) Ub-48-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783049) Ub-29-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783030) Ub-27-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783043) N6-glycyl-L-lysine-UBA52(1-76) [cytosol] (R-HSA-8869043) adenylatedG76-UBA52(1-76) [nucleoplasm] (R-HSA-8852114) UBA52(1-128) [cytosol] (R-HSA-8853517) adenylatedG76-UBA52(1-76) [cytosol] (R-HSA-8852112) Ub-48-UBA52(1-76) [endoplasmic reticulum membrane] (R-HSA-8943067) Ub-48-UBA52(1-76) [lysosomal membrane] (R-HSA-9762994) Ub-48-UBA52(1-76) [endocytic vesicle membrane] (R-HSA-9763054) UBA52(1-76) [endosome membrane] (R-HSA-939189) UBA52(1-76) [plasma membrane] (R-HSA-3149452) Ub-29-UBA52(1-76) [cytosol] (R-HSA-5689209) Ub-6-UBA52(1-76) [cytosol] (R-HSA-5689082) Ub-33-UBA52(1-76) [cytosol] (R-HSA-5689141)	0.556	3
UniProt:Q9UJU6 DBNL	7	DBNL [tertiary granule lumen] (R-HSA-6801516) DBNL [secretory granule lumen] (R-HSA-6801520) DBNL [cytosol] (R-HSA-202880) DBNL(362-431) [cytosol] (R-HSA-202933) DBNL(1-361) [cytosol] (R-HSA-202925) DBNL [ficolin-1-rich granule lumen] (R-HSA-6801510) DBNL [extracellular region] (R-HSA-6801604)	0.556	3
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.556	3
UniProt:P01160 NPPA	5	NPPA(26-55) [extracellular region] (R-HSA-5578794) NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(1-153) [extracellular region] (R-HSA-976950) NPPA(124-151) [extracellular region] (R-HSA-5578799)	0.556	3
UniProt:A0AVK6 E2F8	1	E2F8 [nucleoplasm] (R-HSA-8952990)	0.556	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.556	3
UniProt:O94888 UBXN7	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.556	3
UniProt:P55056 APOC4	1	APOC4 [extracellular region] (R-HSA-5215930)	0.556	3
UniProt:Q9NZH6 IL37	6	IL37(?-218) [nucleoplasm] (R-HSA-9008702) IL37 [extracellular region] (R-HSA-8848334) IL37(?-218) [extracellular region] (R-HSA-9008607) IL37 [cytosol] (R-HSA-9008596) IL37(?-218) [cytosol] (R-HSA-9008584) IL37(1-?) [cytosol] (R-HSA-9008602)	0.556	3
UniProt:P23352 ANOS1	1	KAL1 [extracellular region] (R-HSA-5654345)	0.556	3
UniProt:P05121 SERPINE1	3	SERPINE1 [plasma membrane] (R-HSA-158922) SERPINE1 [platelet alpha granule lumen] (R-HSA-114649) SERPINE1 [extracellular region] (R-HSA-158797)	0.556	3
UniProt:Q04323 UBXN1	2	UBXN1 [cytosol] (R-HSA-8850588) UBXN1 [nucleoplasm] (R-HSA-9707052)	0.556	3
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.556	3
UniProt:P53990 IST1	3	IST1 [extracellular region] (R-HSA-6806231) IST1 [azurophil granule lumen] (R-HSA-6799169) IST1 [cytosol] (R-HSA-9668516)	0.556	3
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.488	2