Reactome | UBQLN1 [cytosol]

UBQLN1 [cytosol]

Stable Identifier

R-HSA-8866006

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquilin-1, UBQL1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UMX0 UBQLN1

Gene Names

UBQLN1, DA41, PLIC1

Chain

initiator methionine:1, chain:2-589

Reference Genes

BioGPS Gene:29979 UBQLN1

COSMIC (genes):UBQLN1 UBQLN1

CTD Gene:29979 UBQLN1

dbSNP Gene:29979 UBQLN1

ENSEMBL:ENSG00000135018 UBQLN1

HGNC:12508 UBQLN1

KEGG Gene (Homo sapiens):29979 UBQLN1

Monarch:29979 UBQLN1

NCBI Gene:29979 UBQLN1

OMIM:605046 UBQLN1

UCSC:Q9UMX0 UBQLN1

Reference Transcript

Other Identifiers

0006100113

0006100278

11734016_s_at

11734017_a_at

11737138_a_at

17095248

222989_s_at

222990_at

222991_s_at

3212144

3212145

3212146

3212147

3212148

3212150

3212151

3212152

3212153

3212156

3212157

3212161

3212162

3212163

3212164

3212165

3212169

3212170

3212171

3212172

3212173

46707_at

57914_at

8161988

82573_at

A_23_P250904

A_23_P250910

A_24_P329597

A_24_P329600

A_24_P338121

GE81838

GO:0000045

GO:0000502

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005773

GO:0005776

GO:0005783

GO:0005829

GO:0005886

GO:0006464

GO:0006511

GO:0006810

GO:0006914

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0009056

GO:0016020

GO:0016235

GO:0016236

GO:0016241

GO:0019899

GO:0019900

GO:0022607

GO:0030433

GO:0031396

GO:0031398

GO:0031410

GO:0031593

GO:0032991

GO:0034140

GO:0034976

GO:0035973

GO:0042802

GO:0043226

GO:0048471

GO:0055085

GO:0071456

GO:0097352

GO:1901340

GO:1902175

GO:1903071

Hs.9589.0.A1_3p_a_at

Hs.9589.0.A3_3p_at

ILMN_1688622

ILMN_1798380

ILMN_2351611

PH_hs_0000988

TC09001280.hg

g12052811_3p_a_at

Participant Of

hasCandidate

UBQLN2,1 [cytosol]

Inferred To

UBQLN1 [cytosol] (Bos taurus)

UBQLN1 [cytosol] (Canis familiaris)

UBQLN1 [cytosol] (Gallus gallus)

UBQLN1 [cytosol] (Plasmodium falciparum)

UBQLN1 [cytosol] (Sus scrofa)

Ubqn [cytosol] (Drosophila melanogaster)

Ubqln1 [cytosol] (Mus musculus)

Ubqln1 [cytosol] (Rattus norvegicus)

ubql-1 [cytosol] (Caenorhabditis elegans)

DSK2 [cytosol] (Saccharomyces cerevisiae)

ubqln [cytosol] (Dictyostelium discoideum)

ubqln1 [cytosol] (Xenopus tropicalis)

dph1 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_038466.2, NP_444295.1

OpenTargets

ENSG00000135018

HPA

ENSG00000135018-UBQLN1

GeneCards

Q9UMX0

Ensembl

ENST00000257468, ENSP00000257468, ENST00000376395, ENSG00000135018, ENSP00000365576

PRO

Q9UMX0

PDB

2JY6, 2JY5, 2KLC

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75084 FZD7	1	FZD7 [plasma membrane] (R-HSA-517394)	0.742	5
UniProt:Q8TCZ2 CD99L2	1	CD99L2 [plasma membrane] (R-HSA-8867207)	0.718	6
UniProt:Q9NUQ2 AGPAT5	2	AGPAT5 [endoplasmic reticulum membrane] (R-HSA-61811) AGPAT5 [mitochondrial outer membrane] (R-HSA-1500585)	0.718	6
UniProt:P04155 TFF1	1	TFF1 [extracellular region] (R-HSA-9017879)	0.666	6
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.592	4
UniProt:P12318 FCGR2A	3	FCGR2A [plasma membrane] (R-HSA-197838) FCGR2A [secretory granule membrane] (R-HSA-6804791) p-Y288,Y304-FCGR2A [plasma membrane] (R-HSA-2029069)	0.556	3
UniProt:P01160 NPPA	5	NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(26-55) [extracellular region] (R-HSA-5578794) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-153) [extracellular region] (R-HSA-976950)	0.556	3
UniProt:Q969H8 MYDGF	1	C19orf10 [endoplasmic reticulum lumen] (R-HSA-535584)	0.556	3
UniProt:Q6ISS4 LAIR2	1	LAIR2 [extracellular region] (R-HSA-5696342)	0.556	3
UniProt:P42566 EPS15	2	EPS15 [cytosol] (R-HSA-182920) p-Y850 EPS15 [cytosol] (R-HSA-8867028)	0.556	5
UniProt:P62979 RPS27A	40	RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-27-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783176) N6-glycyl-L-lysine-RPS27A(1-76) [cytosol] (R-HSA-8869045) Ub-29-RPS27A(1-76) [cytosol] (R-HSA-5689223) Ub-6-RPS27A(1-76) [cytosol] (R-HSA-5689098) Ub-33-RPS27A(1-76) [cytosol] (R-HSA-5689170) adenylatedlG76-RPS27A(1-76) [nucleoplasm] (R-HSA-8852078) RPS27A [cytosol] (R-HSA-8853524) adenylatedlG76-RPS27A(1-76) [cytosol] (R-HSA-8852065) Ub-48-RPS27A(1-76) [endoplasmic reticulum membrane] (R-HSA-8943102) RPS27A(1-76) [endoplasmic reticulum membrane] (R-HSA-8943127) RPS27A(1-76) [plasma membrane] (R-HSA-3149457) RPS27A(1-76) [endosome membrane] (R-HSA-939238) RPS27A(77-156) [cytosol] (R-HSA-72363) Ub-27-RPS27A(1-76) [cytosol] (R-HSA-5689154) Ub-11-RPS27A(1-76) [cytosol] (R-HSA-3095933) Ub-63-RPS27A(1-76) [endosome membrane] (R-HSA-939222) Ub-63-RPS27A(1-76) [plasma membrane] (R-HSA-939855) Ub-27-RPS27A(1-76) [nucleoplasm] (R-HSA-6782671) Ub-29-RPS27A(1-76) [nucleoplasm] (R-HSA-6782593) Ub-63-RPS27A(1-76) [nucleoplasm] (R-HSA-6782503) Ub-48-RPS27A(1-76) [nucleoplasm] (R-HSA-6782471) Ub-11-RPS27A(1-76) [nucleoplasm] (R-HSA-6782679) Ub-33-RPS27A(1-76) [nucleoplasm] (R-HSA-6782618) Ub-6-RPS27A(1-76) [nucleoplasm] (R-HSA-6782608) RPS27A(1-76) [nucleoplasm] (R-HSA-939849) Ub-48-RPS27A(1-76) [nucleoplasm] (R-HSA-5683037) Ub-63-RPS27A(1-76) [nucleoplasm] (R-HSA-5682849) RPS27A(1-76) [late endosome lumen] (R-HSA-9660022) Ub-48-RPS27A(1-76) [cytosol] (R-HSA-939202) RPS27A(1-76) [cytosol] (R-HSA-939205) RPS27A(1-76) [lysosomal lumen] (R-HSA-9660001) Ub-63-RPS27A(1-76) [cytosol] (R-HSA-939248)	0.556	3
UniProt:P55056 APOC4	1	APOC4 [extracellular region] (R-HSA-5215930)	0.556	3
UniProt:P23352 ANOS1	1	KAL1 [extracellular region] (R-HSA-5654345)	0.556	3
UniProt:P22466 GAL	1	GAL [extracellular region] (R-HSA-389038)	0.556	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:P50553 ASCL1	1	ASCL1 [nucleoplasm] (R-HSA-212402)	0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:P02751 FN1	8	FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.556	3
UniProt:O94888 UBXN7	1	UBXN7 [cytosol] (R-HSA-8956071)	0.556	3
UniProt:P53990 IST1	3	IST1 [azurophil granule lumen] (R-HSA-6799169) IST1 [extracellular region] (R-HSA-6806231) IST1 [cytosol] (R-HSA-9668516)	0.556	3
UniProt:P62987 UBA52	39	Ub-33-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783187) UBA52(1-76) [endocytic vesicle membrane] (R-HSA-939236) Ub-63-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783039) Ub-6-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783072) Ub-11-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783059) Ub-48-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783049) Ub-29-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783030) Ub-27-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783043) N6-glycyl-L-lysine-UBA52(1-76) [cytosol] (R-HSA-8869043) Ub-29-UBA52(1-76) [cytosol] (R-HSA-5689209) Ub-6-UBA52(1-76) [cytosol] (R-HSA-5689082) Ub-33-UBA52(1-76) [cytosol] (R-HSA-5689141) adenylatedG76-UBA52(1-76) [nucleoplasm] (R-HSA-8852114) UBA52(1-128) [cytosol] (R-HSA-8853517) adenylatedG76-UBA52(1-76) [cytosol] (R-HSA-8852112) Ub-48-UBA52(1-76) [endoplasmic reticulum membrane] (R-HSA-8943067) UBA52(1-76) [endoplasmic reticulum membrane] (R-HSA-8943092) UBA52(1-76) [plasma membrane] (R-HSA-3149452) UBA52(1-76) [endosome membrane] (R-HSA-939189) RPL40 [cytosol] (R-HSA-72476) Ub-27-UBA52(1-76) [cytosol] (R-HSA-5689174) Ub-11-UBA52(1-76) [cytosol] (R-HSA-3095931) Ub-63-UBA52(1-76) [endosome membrane] (R-HSA-939185) Ub-63-UBA52(1-76) [plasma membrane] (R-HSA-939851) Ub-27-UBA52(1-76) [nucleoplasm] (R-HSA-6782610) Ub-29-UBA52(1-76) [nucleoplasm] (R-HSA-6782612) Ub-63-UBA52(1-76) [nucleoplasm] (R-HSA-6782530) Ub-48-UBA52(1-76) [nucleoplasm] (R-HSA-6782481) Ub-11-UBA52(1-76) [nucleoplasm] (R-HSA-6782647) Ub-33-UBA52(1-76) [nucleoplasm] (R-HSA-6782658) Ub-6-UBA52(1-76) [nucleoplasm] (R-HSA-6782616) UBA52(1-76) [nucleoplasm] (R-HSA-939844) Ub-48-UBA52(1-76) [nucleoplasm] (R-HSA-5683034) Ub-63-UBA52(1-76) [nucleoplasm] (R-HSA-5682838) UBA52(1-76) [late endosome lumen] (R-HSA-9660003) Ub-48-UBA52(1-76) [cytosol] (R-HSA-939250) UBA52(1-76) [cytosol] (R-HSA-939203) UBA52(1-76) [lysosomal lumen] (R-HSA-9660000) Ub-63-UBA52(1-76) [cytosol] (R-HSA-939169)	0.556	3
UniProt:P05121 SERPINE1	4	SERPINE1 [platelet alpha granule lumen] (R-HSA-114649) SERPINE1 [plasma membrane] (R-HSA-158922) SERPINE1 [extracellular region] (R-HSA-158797) SERPINE1 [extracellular region] (R-HSA-61271)	0.556	3
UniProt:P08294 SOD3	3	SOD3 (19-227) [extracellular region] (R-HSA-4837350) SOD3 [Golgi lumen] (R-HSA-3697878) SOD3 [extracellular region] (R-HSA-3299690)	0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.556	3
UniProt:Q8IW45 NAXD	1	CARKD [mitochondrial matrix] (R-HSA-6806970)	0.556	3
UniProt:Q09472 EP300	5	Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.488	2