ARBB recruits GPCRs into clathrin-coated pits

Stable Identifier
R-HSA-8866283
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Interaction between beta-arrestins and components of the clathrin-coat mediate the recruitment of GPCRs into nascent clathrin-coated pits (Shenoy et al, 2001; Goodman et al, 1997; Goodman et al, 1997; Laporte et al, 1999; reviewed in Gurevich and Gurevich, 2006). In the case of the V2 vasopressin receptor (AVPR2) and the beta-2 adrenergic receptor (ADRB2), this beta-arrestin-mediated recruitment into clathrin-coated pits is negatively regulated by UBQLN2, possibly through competition for binding to the UIM-containing proteins such as EPS15, EPN1 and EPN2 (N'Diaye et al, 2008).

Literature References
PubMed ID Title Journal Year
9169477 Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain

Goodman, OB, Krupnick, JG, Gurevich, VV, Benovic, JL, Keen, JH

J. Biol. Chem. 1997
18199683 The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis

N'Diaye, EN, Hanyaloglu, AC, Kajihara, KK, Puthenveedu, MA, Wu, P, von Zastrow, M, Brown, EJ

Mol. Biol. Cell 2008
11588219 Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

Shenoy, SK, McDonald, PH, Kohout, TA, Lefkowitz, RJ

Science 2001
16460808 The structural basis of arrestin-mediated regulation of G-protein-coupled receptors

Gurevich, VV, Gurevich, EV

Pharmacol. Ther. 2006
10097102 The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

Laporte, SA, Oakley, RH, Zhang, J, Holt, JA, Ferguson, SS, Caron, MG, Barak, LS

Proc. Natl. Acad. Sci. U.S.A. 1999
8837779 Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

Goodman, OB, Krupnick, JG, Santini, F, Gurevich, VV, Penn, RB, Gagnon, AW, Keen, JH, Benovic, JL

Nature 1996
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