Reactome | ARBB recruits GPCRs into clathrin-coated pits

ARBB recruits GPCRs into clathrin-coated pits

Stable Identifier

R-HSA-8866283

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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ARBB recruits GPCRs into clathrin-coated pits

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Interaction between beta-arrestins and components of the clathrin-coat mediate the recruitment of GPCRs into nascent clathrin-coated pits (Shenoy et al, 2001; Goodman et al, 1997; Goodman et al, 1997; Laporte et al, 1999; reviewed in Gurevich and Gurevich, 2006). In the case of the V2 vasopressin receptor (AVPR2) and the beta-2 adrenergic receptor (ADRB2), this beta-arrestin-mediated recruitment into clathrin-coated pits is negatively regulated by UBQLN2, possibly through competition for binding to the UIM-containing proteins such as EPS15, EPN1 and EPN2 (N'Diaye et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
18199683	The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis Kajihara, KK, Brown, EJ, Puthenveedu, MA, von Zastrow, M, Wu, P, N'Diaye, EN, Hanyaloglu, AC	Mol. Biol. Cell	2008
9169477	Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain Benovic, JL, Gurevich, VV, Krupnick, JG, Goodman, OB, Keen, JH	J. Biol. Chem.	1997
11588219	Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin Shenoy, SK, Kohout, TA, McDonald, PH, Lefkowitz, RJ	Science	2001
16460808	The structural basis of arrestin-mediated regulation of G-protein-coupled receptors Gurevich, EV, Gurevich, VV	Pharmacol. Ther.	2006
10097102	The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis Oakley, RH, Caron, MG, Holt, JA, Zhang, J, Barak, LS, Ferguson, SS, Laporte, SA	Proc. Natl. Acad. Sci. U.S.A.	1999
8837779	Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor Benovic, JL, Gurevich, VV, Penn, RB, Krupnick, JG, Santini, F, Gagnon, AW, Goodman, OB, Keen, JH	Nature	1996