Reelin signalling pathway

Stable Identifier
R-HSA-8866376
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Reelin (RELN) is an extracellular, multifunctional signal glycoprotein that controls not only the positioning of neurons in the developing brain, but also their growth, maturation, and synaptic activity in the adult brain (Stranahan et al. 2013). Abnormal Reelin expression in the brain is implicated in a number of neuropsychiatric disorders including autism, schizophrenia, bipolar disorder and Alzheimer's disease (Folsom & Fatemi 2013).

Literature References
PubMed ID Title Journal Year
22981949 The involvement of Reelin in neurodevelopmental disorders Neuropharmacology 2013
23352928 Reelin signaling in development, maintenance, and plasticity of neural networks Ageing Res. Rev. 2013
Participants
Participant Of
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Orthologous Events