VLDL assembly

Stable Identifier
R-HSA-8866423
Type
Pathway
Species
Homo sapiens
Synonyms
VLDL biosynthesis
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Very low-density lipoprotein (VLDL) is synthesised in the liver in two steps. First, apolipoprotein B-100 (APOB-100) is co- and post-translationally lipidated in the rough ER lumen. After transfer to the smooth ER lumen, lipidated APOB-100 acquires lipids to become bona fide VLDL. Lipid composition of VLDL - triglycerides (50-60%), cholesterol (10-12%), cholesterol esters (4-6%), phospholipids (18-20%), and apolipoprotein B (8-12%). When VLDL assembly is complete, it travels along the Golgi apparatus to be eventually secreted from the liver into general circulation. In circulation, VLDL can acquire more lipoproteins. At least two other apolipoproteins are constituents; apolipoprotein C-I (APOC1, around 20%) and apolipoprotein C4 (APOC4, minor amount) (Gibbons et al. 2004; Olofsson et al. 2000).

Literature References
PubMed ID Title Journal Year
14748713 Synthesis and function of hepatic very-low-density lipoprotein

Gibbons, GF, Wiggins, D, Brown, AM, Hebbachi, AM

Biochem. Soc. Trans. 2004
11369260 Intracellular assembly of VLDL: two major steps in separate cell compartments

Olofsson, SO, Stillemark-Billton, P, Asp, L

Trends Cardiovasc. Med. 2000
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