VLDLR internalisation and degradation

Stable Identifier
R-HSA-8866427
Type
Pathway
Species
Homo sapiens
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The steps involved in proprotein convertase PCSK9-induced degradation of VLDLR are described here (Poirier et al. 2008). The rate of this catabolic process plays a clinically significant role in determining the efficiency of lipoprotein clearance from the blood.

Literature References
PubMed ID Title Journal Year
18039658 The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

Poirier, S, Mayer, G, Benjannet, S, Bergeron, E, Marcinkiewicz, J, Nassoury, N, Mayer, H, Nimpf, J, Prat, A, Seidah, NG

J. Biol. Chem. 2008
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