Reactome | RNF5 and RNF185 ubiquitinate misfolded CFTR

RNF5 and RNF185 ubiquitinate misfolded CFTR

Stable Identifier

R-HSA-8866546

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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RNF5 and RNF185 ubiquitinate misfolded CFTR as part of the retrotranslocon that targets the receptor for degradation through the ERAD pathway. Both depletion of the E3 ligases by siRNA and expression of a catalytically inactive form of the enzyme strongly inhibits CFTR degradation (El Khouri et al, 2013; Younger et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
24019521	RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR) El Khouri, E, Toledano, MB, Le Pavec, G, Delaunay-Moisan, A	J. Biol. Chem.	2013
16901789	Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator Fan, CY, Ren, HY, Rosser, MF, Younger, JM, Cyr, DM, Turnbull, EL, Chen, L, Patterson, C	Cell	2006