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PAF1 [nucleoplasm]
Stable Identifier
R-HSA-8866689
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RNA polymerase II-associated factor 1 homolog, PAF1_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Abortive termination of elongation after arrest (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Resumption of elongation after recovery from pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Addition of nucleotides leads to transcript elongation (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Separation of elongating transcript from template (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N7H5 PAF1
Gene Names
PAF1, PD2
Chain
chain:1-531
Reference Genes
BioGPS Gene:54623 PAF1
COSMIC (genes):PAF1 PAF1
CTD Gene:54623 PAF1
dbSNP Gene:54623 PAF1
ENSEMBL:ENSG00000006712 PAF1
ENSEMBL_homo_sapiens_GENE:ENSG00000006712.15 PAF1
HGNC:25459 PAF1
KEGG Gene (Homo sapiens):54623 PAF1
Monarch:54623 PAF1
NCBI Gene:54623 PAF1
OMIM:610506 PAF1
UCSC:Q8N7H5 PAF1
Reference Transcript
RefSeq:NM_019088.3 PAF1
RefSeq:NM_001256826.1 PAF1
Other Identifiers
11744204_a_at
11749516_a_at
16872203
202093_PM_s_at
202093_s_at
31866_at
3861979
3861980
3861981
3861982
3861984
3861985
3861987
3861988
3861989
3861990
3861992
3861994
3861995
3861996
3861999
3862000
3862001
3862002
3862003
54623
8036720
A_23_P142272
A_24_P216087
GE55976
GO:0000122
GO:0000993
GO:0001650
GO:0001711
GO:0002376
GO:0003682
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006351
GO:0006355
GO:0006368
GO:0006378
GO:0016020
GO:0016055
GO:0016071
GO:0016570
GO:0016593
GO:0019827
GO:0023052
GO:0030154
GO:0031442
GO:0034504
GO:0036211
GO:0043226
GO:0043231
GO:0045638
GO:0045944
GO:0048856
GO:0071222
GO:1902808
HMNXSV003048607
ILMN_1669508
PH_hs_0009194
TC19001518.hg
g9506582_3p_a_at
Participates
as a component of
PAF1C [nucleoplasm] (Homo sapiens)
Inferred To
PAF1 [nucleoplasm]
(Bos taurus)
PAF1 [nucleoplasm]
(Canis familiaris)
PAF1 [nucleoplasm]
(Gallus gallus)
PAF1 [nucleoplasm]
(Saccharomyces cerevisiae)
PAF1 [nucleoplasm]
(Schizosaccharomyces pombe)
PAF1 [nucleoplasm]
(Sus scrofa)
Paf1 [nucleoplasm]
(Mus musculus)
Paf1 [nucleoplasm]
(Rattus norvegicus)
paf1 [nucleoplasm]
(Danio rerio)
paf1 [nucleoplasm]
(Dictyostelium discoideum)
paf1 [nucleoplasm]
(Xenopus tropicalis)
pafo-1 [nucleoplasm]
(Caenorhabditis elegans)
atms [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001243755.1
,
NP_061961.2
OpenTargets
ENSG00000006712
HPA
ENSG00000006712-PAF1
GeneCards
Q8N7H5
Ensembl
ENSP00000468874
,
ENSP00000221265
,
ENST00000221265
,
ENST00000595564
,
ENSG00000006712
PRO
Q8N7H5
Pharos - Targets
Q8N7H5
PDB
7UND
,
6TED
,
7OPC
,
5ZYQ
,
6GMH
,
7UNC
,
7OOP
,
4M6T
,
7OPD
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.956
31
UniProt:Q8WVC0 LEO1
1
LEO1 [nucleoplasm]
(R-HSA-3322361)
0.945
28
UniProt:P23193 TCEA1
1
TCEA1 [nucleoplasm]
(R-HSA-65748)
0.577
4
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.527
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.508
2
UniProt:Q03164 KMT2A
6
KMT2A [cytosol]
(R-HSA-9818584)
KMT2A(2719-3969) [cytosol]
(R-HSA-9818590)
KMT2A(1-2718) [cytosol]
(R-HSA-9818597)
KMT2A [nucleoplasm]
(R-HSA-1183223)
KMT2A(1-2718) [nucleoplasm]
(R-HSA-9818591)
KMT2A(2719-3969) [nucleoplasm]
(R-HSA-9818593)
0.499
4
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