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WDR61 [nucleoplasm]
Stable Identifier
R-HSA-8866696
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
WD repeat-containing protein 61, WDR61_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Abortive termination of elongation after arrest (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Resumption of elongation after recovery from pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Addition of nucleotides leads to transcript elongation (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Separation of elongating transcript from template (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9GZS3 SKIC8
Gene Names
SKIC8, WDR61
Chain
chain:1-305, initiator methionine:, chain:2-305
Reference Genes
BioGPS Gene:80349 SKIC8
COSMIC (genes):WDR61 SKIC8
CTD Gene:80349 SKIC8
dbSNP Gene:80349 SKIC8
ENSEMBL:ENSG00000140395 WDR61
HGNC:30300 SKIC8
KEGG:hsa:80349 SKIC8
Monarch:80349 SKIC8
NCBI Gene:80349 SKIC8
OMIM:609540 SKIC8
UCSC:Q9GZS3 SKIC8
Reference Transcript
RefSeq:XM_011522094.1 SKIC8
RefSeq:NM_001303247.1 SKIC8
RefSeq:NM_001303248.1 SKIC8
RefSeq:NM_025234.2 SKIC8
Other Identifiers
11757639_a_at
11761627_a_at
16812142
221531_PM_at
221531_at
221532_PM_s_at
221532_s_at
232075_PM_at
232075_at
237208_PM_at
237208_at
3634589
3634590
3634594
3634595
3634596
3634597
3634598
3634599
3634600
3634601
3634602
3634603
3634604
3634605
3634606
3634607
3634608
3634609
3634610
3634611
3634612
3634613
3634614
3634616
3634617
3634618
3634619
3634620
3634621
3634622
3634624
3634625
3634626
36431_at
73479_at
7990700
80349
90320_at
A_23_P49021
GE56402
GE79470
GE84923
GO:0000791
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006368
GO:0016055
GO:0016071
GO:0016593
GO:0043226
GO:0045638
GO:0055087
GO:0070478
GO:0072344
HMNXSV003009479
Hs.125457.0.A1_3p_at
Hs.167456.0.S1_3p_at
Hs.306765.0.S1_3p_at
ILMN_1665887
PH_hs_0022380
TC15001703.hg
g11139241_3p_at
g11139241_3p_s_at
Participates
as a component of
PAF1C [nucleoplasm] (Homo sapiens)
Other forms of this molecule
WDR61 [cytosol]
Inferred To
SKIC8 [nucleoplasm]
(Bos taurus)
SKIC8 [nucleoplasm]
(Canis familiaris)
SKIC8 [nucleoplasm]
(Sus scrofa)
skic8 [nucleoplasm]
(Danio rerio)
skic8 [nucleoplasm]
(Dictyostelium discoideum)
skic8 [nucleoplasm]
(Xenopus tropicalis)
SKI8 [nucleoplasm]
(Saccharomyces cerevisiae)
rec14 [nucleoplasm]
(Schizosaccharomyces pombe)
Skic8 [nucleoplasm]
(Mus musculus)
Skic8 [nucleoplasm]
(Rattus norvegicus)
Dmel\CG3909 [nucleoplasm]
(Drosophila melanogaster)
WDR61 [nucleoplasm]
(Caenorhabditis elegans)
WDR61 [nucleoplasm]
(Gallus gallus)
Cross References
OpenTargets
ENSG00000140395
ENSEMBL
ENST00000558311
,
ENSP00000453801
,
ENSG00000140395
,
ENSP00000267973
,
ENST00000267973
HPA
ENSG00000140395-SKIC8
GeneCards
SKIC8
PRO
Q9GZS3
Pharos - Targets
Q9GZS3
GlyGen
Q9GZS3
PDB
7UND
,
7QDY
,
7UNC
,
7OOP
,
7QDZ
,
3OW8
,
6TED
,
7QDS
,
8A3Y
,
7OPC
,
7QDR
,
7OPD
,
6GMH
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.905
13
UniProt:Q8WVC0 LEO1
1
LEO1 [nucleoplasm]
(R-HSA-3322361)
0.725
7
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
22
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:P00441 SOD1
5
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [extracellular region]
(R-HSA-350705)
0.556
3
UniProt:Q16143 SNCB
1
SNCB [cytosol]
(R-HSA-5660390)
0.556
3
UniProt:P51149 RAB7A
7
RAB7A [secretory granule membrane]
(R-HSA-6804969)
RAB7A [plasma membrane]
(R-HSA-6804990)
RAB7A [cytosol]
(R-HSA-8870415)
RAB7A [phagocytic vesicle membrane]
(R-HSA-9636586)
RAB7A [lysosomal membrane]
(R-HSA-2213231)
GGC-RAB7A [cytosol]
(R-HSA-8870438)
GGC-RAB7A [lysosomal membrane]
(R-HSA-8877454)
0.556
3
UniProt:P02545-2 LMNA
5
LMNA-2 [cytosol]
(R-HSA-2995387)
Lamin C [nucleoplasm]
(R-HSA-264872)
p-S395-LMNA-2 [nucleoplasm]
(R-HSA-5228740)
p-S22, S395-LMNA-2 [nucleoplasm]
(R-HSA-5229019)
LMNA-2 [nuclear envelope]
(R-HSA-912378)
0.556
3
UniProt:Q99497 PARK7
7
PolyUb-Misfolded PARK7 [lysosomal lumen]
(R-HSA-9659997)
PolyUb-Misfolded PARK7 [cytosol]
(R-HSA-9641128)
Ub-Misfolded PARK7 [cytosol]
(R-HSA-9641123)
Misfolded PARK7 [cytosol]
(R-HSA-9641100)
PolyUb-Misfolded PARK7 [late endosome lumen]
(R-HSA-9660005)
PARK7 [nucleoplasm]
(R-HSA-3900141)
monoSUMO1-K130-PARK7 [nucleoplasm]
(R-HSA-4085351)
0.556
3
UniProt:P29474 NOS3
9
2xPalmC-MyrG-NOS3 [plasma membrane]
(R-HSA-534993)
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(R-HSA-202139)
2xPalmC-MyrG-NOS3 [Golgi membrane]
(R-HSA-203769)
MyrG-NOS3 [cytosol]
(R-HSA-203687)
MyrG-NOS3 [Golgi membrane]
(R-HSA-534995)
NOS3 [cytosol]
(R-HSA-202114)
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
(R-HSA-535007)
2xPalmC-MyrG-p-S633-NOS3 [plasma membrane]
(R-HSA-9861341)
2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane]
(R-HSA-9860783)
0.556
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:Q16595 FXN
6
FXN(81-210) [mitochondrial matrix]
(R-HSA-1362390)
FXN(1-41) [mitochondrial matrix]
(R-HSA-8986117)
FXN(1-210) [mitochondrial inner membrane]
(R-HSA-1299444)
FXN(42-210) [mitochondrial inner membrane]
(R-HSA-1299454)
FXN(1-210) [mitochondrial intermembrane space]
(R-HSA-1299451)
FXN(42-210) [mitochondrial matrix]
(R-HSA-1299445)
0.556
3
UniProt:O75533 SF3B1
1
SF3B1 [nucleoplasm]
(R-HSA-71968)
0.527
2
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