Reactome | ub-CFTR F508del [cytosol]

ub-CFTR F508del [cytosol]

Stable Identifier

R-HSA-8866838

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cystic fibrosis transmembrane conductance regulator, CFTR_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P13569 CFTR

Gene Names

CFTR, ABCC7

Chain

chain:1-1480

Reference Genes

BioGPS Gene:1080 CFTR

COSMIC (genes):CFTR CFTR

CTD Gene:1080 CFTR

dbSNP Gene:1080 CFTR

ENSEMBL:ENSG00000001626 CFTR

ENSEMBL:ENSG00000001626.18 CFTR

HGNC:1884 CFTR

KEGG Gene (Homo sapiens):1080 CFTR

Monarch:1080 CFTR

NCBI Gene:1080 CFTR

OMIM:602421 CFTR

UCSC:P13569 CFTR

Reference Transcript

RefSeq:NM_000492.3 CFTR

Other Identifiers

1080

11722757_at

17050697

205043_PM_at

205043_at

215702_PM_s_at

215702_s_at

3020647

3020648

3020652

3020654

3020658

3020659

3020661

3020662

3020663

3020664

3020666

3020667

3020668

3020670

3020672

3020673

3020674

3020679

3020680

3020682

3020683

3020684

3020685

3020686

3020688

3020689

3020694

3020695

3020696

3020698

3020699

3020701

3020702

3020705

3020706

3020707

3020712

3020719

3020721

3020722

3020723

3020724

3020725

3020726

3020727

36816_s_at

36817_at

3902164

3902300

8135661

A_14_P104877

A_14_P114787

A_14_P129538

A_14_P132049

A_23_P215720

GE62403

GO:0000166

GO:0003824

GO:0005215

GO:0005254

GO:0005260

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005773

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006629

GO:0006695

GO:0006811

GO:0006821

GO:0006904

GO:0009986

GO:0010008

GO:0015106

GO:0015108

GO:0015701

GO:0016020

GO:0016192

GO:0016324

GO:0016787

GO:0016853

GO:0016887

GO:0017081

GO:0019869

GO:0019899

GO:0022414

GO:0023052

GO:0030154

GO:0030165

GO:0030301

GO:0030660

GO:0030669

GO:0031410

GO:0031901

GO:0032991

GO:0034707

GO:0034976

GO:0035377

GO:0035774

GO:0042626

GO:0043225

GO:0043226

GO:0045921

GO:0048240

GO:0048856

GO:0050891

GO:0051087

GO:0051454

GO:0051649

GO:0055037

GO:0055038

GO:0055085

GO:0060081

GO:0070175

GO:0071320

GO:0097186

GO:0098772

GO:0106138

GO:0140359

GO:0140657

GO:1902161

GO:1902476

GO:1902943

GO:1904322

HMNXSV003020096

Hs.663.1.A1_3p_a_at

ILMN_1705813

M55131_at

PH_hs_0024884

TC07000726.hg

g6995995_3p_at

Participates

as a component of

ub-CFTR F508del [cytosol] (Homo sapiens)

Other forms of this molecule

PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]

PolyUb-CFTR [plasma membrane]

CFTR [lysosomal membrane]

CFTR [Golgi-associated vesicle membrane]

CFTR [endosome membrane]

PolyUb-CFTR [endosome membrane]

CFTR F508del [endoplasmic reticulum membrane]

ub-CFTR F508del [endoplasmic reticulum membrane]

CFTR G542* [plasma membrane]

CFTR G551D [plasma membrane]

CFTR W1282* [plasma membrane]

CFTR F508del [plasma membrane]

CFTR N1303K [plasma membrane]

CFTR [plasma membrane]

CFTR [endoplasmic reticulum membrane]

misfolded CFTR [endoplasmic reticulum membrane]

Modified Residues

Name

Deletion of residues 508 to 508

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Disease

Name	Identifier	Synonyms
cystic fibrosis	DOID:1485	mucoviscidosis, CF

Cross References

RefSeq

NP_000483.3

ZINC - World Drugs

CFTR_HUMAN

Guide to Pharmacology - Targets

707

OpenTargets

ENSG00000001626

ZINC - FDA approved

CFTR_HUMAN

ZINC - Substances

CFTR_HUMAN

ZINC - Biogenic

CFTR_HUMAN

ZINC target

P13569

PRO

P13569

PDB

8EIQ, 5TFG, 6UK1, 8EIO, 5TF8, 6MSM, 6GJQ, 3ISW, 6HEP, 6GJS, 3GD7, 5UAK, 6O2P, 1XMI, 8EJ1, 5TFI, 6GKD, 8EIG, 6O1V, 5TFD, 2LOB, 5D2D, 7SVR, 5TFF, 7QI1, 5TGK, 5TF7, 8FZQ, 5TFC, 2PZF, 5TFB, 6ZE1, 2BBT, 5D3F, 2PZG, 7SVD, 4WZ6, 6WBS, 5TFJ, 1XMJ, 2BBO, 6GJU, 5TFA, 6GK4, 7SV7, 2PZE, 5D3E, 2BBS

IntEnz

5.6.1.6

GeneCards

P13569

HPA

ENSG00000001626-CFTR

Ensembl

ENST00000003084, ENST00000649781, ENSG00000001626, ENSP00000497203, ENSP00000003084

Pharos - Targets

P13569

Orphanet

15441

ZINC - Predictions - Purchasable

CFTR_HUMAN

HMDB Protein

HMDBP02121

Interactors (656)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14745 NHRF1			0.932	21
UniProt:Q15599 NHRF2			0.901	20
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.853	16
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.851	20
UniProt:Q9HD26 GOPC	3	GOPC [lysosomal membrane] (R-HSA-5627281) GOPC [plasma membrane] (R-HSA-5626572) GOPC [Golgi-associated vesicle membrane] (R-HSA-5627067)	0.767	10
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.731	6
UniProt:Q9UN37 VPS4A	1	VPS4A [cytosol] (R-HSA-917732)	0.725	7
UniProt:Q9Y678 COPG1	4	COPG1 [endoplasmic reticulum membrane] (R-HSA-6810960) COPG1 [Golgi membrane] (R-HSA-6808747) COPG1 [transport vesicle] (R-HSA-6808749) COPG1 [cytosol] (R-HSA-199987)	0.725	15
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.725	12
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.725	16
UniProt:O00299 CLIC1			0.725	12
UniProt:Q92734 TFG	7	TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702019) TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702038) TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9702029) TFG(1-193)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699887) TFG(1-138)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699874) TFG(1-240)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699806) TFG [cytosol] (R-HSA-5688159)	0.707	7
UniProt:P02545 LMNA	3	LMNA(1-646) [nuclear envelope] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.706	17
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.706	17
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.706	17
UniProt:P06702 S100A9	3	S100A9 [cytosol] (R-HSA-9626869) S100A9 [secretory granule lumen] (R-HSA-6804774) S100A9 [extracellular region] (R-HSA-5432857)	0.706	12
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714)	0.706	16
UniProt:P31689 DNAJA1	1	DNAJA1 [cytosol] (R-HSA-3371544)	0.706	19
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.702	12
UniProt:Q5T2W1 NHRF3			0.702	6
UniProt:P05787 KRT8	1	KRT8 [cytosol] (R-HSA-446043)	0.677	11
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.671	16
UniProt:Q14694 USP10	3	USP10 [cytosol] (R-HSA-6782974) K63polyUb-USP10 [cytosol] (R-HSA-6782986) USP10 [nucleoplasm] (R-HSA-3222218)	0.665	7
UniProt:P60981 DEST			0.659	10
UniProt:P31040 SDHA	1	SDHA [mitochondrial inner membrane] (R-HSA-70983)	0.659	9
UniProt:Q9QX74	1	Shank2 [cytosol] (R-RNO-6794265)	0.658	3
UniProt:Q9H8Y8 GORASP2	2	GORASP2 [Golgi membrane] (R-HSA-2422385) p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965)	0.646	6
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.643	11
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.643	7
UniProt:P31151 S100A7	2	S100A7 [azurophil granule lumen] (R-HSA-6799207) S100A7 [extracellular region] (R-HSA-5432925)	0.643	10
UniProt:P13987 CD59	8	CD59 [tertiary granule membrane] (R-HSA-6800885) CD59 [specific granule membrane] (R-HSA-6799513) GPI-CD59 [Golgi membrane] (R-HSA-6808772) GPI-CD59 [transport vesicle] (R-HSA-6808775) GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689804) GPI-CD59 [ER to Golgi transport vesicle membrane] (R-HSA-5689801) GPI-CD59 [endoplasmic reticulum membrane] (R-HSA-5689453) CD59 [plasma membrane] (R-HSA-2530458)	0.643	9
UniProt:Q15370 ELOB	2	TCEB2 [nucleoplasm] (R-HSA-112423) ELOB [cytosol] (R-HSA-180551)	0.643	12
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.64	13
UniProt:Q01518 CAP1	3	CAP1 [cytosol] (R-HSA-350758) CAP1 [extracellular region] (R-HSA-350746) CAP1 [azurophil granule lumen] (R-HSA-6798752)	0.64	9
UniProt:Q9Y295 DRG1	2	3OHK22-DRG1 [cytosol] (R-HSA-9629587) DRG1 [cytosol] (R-HSA-9629563)	0.64	9
UniProt:P09972 ALDOC	5	ALDOC [tertiary granule lumen] (R-HSA-6801526) ALDOC [secretory granule lumen] (R-HSA-6801483) ALDOC [extracellular region] (R-HSA-6801553) ALDOC [ficolin-1-rich granule lumen] (R-HSA-6801464) ALDOC [cytosol] (R-HSA-70455)	0.64	8
UniProt:O95793 STAU1			0.64	8
UniProt:P62158 CALM			0.64	11
UniProt:P30101 PDIA3	3	PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.64	7
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.64	16
UniProt:Q99942 RNF5	1	RNF5 [endoplasmic reticulum membrane] (R-HSA-975990)	0.636	7
UniProt:Q9NUU7 DD19A			0.618	9
UniProt:O14545 TRAD1			0.618	6
UniProt:Q9UEU0 VTI1B	2	VTI1B [extracellular region] (R-HSA-8862983) VTI1B [platelet alpha granule lumen] (R-HSA-8862964)	0.618	10
UniProt:Q9Y608 LRRF2			0.615	10
UniProt:P14866 HNRNPL	1	HNRNPL [nucleoplasm] (R-HSA-71947)	0.615	12
UniProt:Q96CS3 FAF2	3	FAF2 [cytosol] (R-HSA-6781921) FAF2 [extracellular region] (R-HSA-6806183) FAF2 [azurophil granule lumen] (R-HSA-6799138)	0.615	9
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.615	14
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.615	15
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.615	9
UniProt:P00338 LDHA	1	LDHA [cytosol] (R-HSA-70502)	0.615	14
UniProt:P55060 XPO2			0.615	15
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.615	13
UniProt:P62910 RPL32	1	RPL32 [cytosol] (R-HSA-72456)	0.615	11
UniProt:P13667 PDIA4			0.615	11
UniProt:Q06830 PRDX1	3	p-T90-PRDX1 [cytosol] (R-HSA-8868564) PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198)	0.615	15
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.615	12
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.615	14
UniProt:P17812 CTPS1	1	CTPS1 [cytosol] (R-HSA-73536)	0.615	14
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.615	14
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.615	10
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.615	12
UniProt:P38646 HSPA9	6	HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964)	0.615	15
UniProt:P56192 MARS1	1	MARS [cytosol] (R-HSA-379657)	0.615	12
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.615	7
UniProt:P23246 SFPQ	3	SFPQ [cytosol] (R-HSA-9635505) p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [nucleoplasm] (R-HSA-3900138)	0.615	14
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.615	13
UniProt:Q9UHB6 LIMA1			0.615	15
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.615	13
UniProt:Q9P2E9 RRBP1	2	RRBP1(1-1253)insTPERALSSGLH-p-6Y-ALK(1106-1620) fusion [endoplasmic reticulum membrane] (R-HSA-9702011) RRBP1(1-1253)insTPERALSSGLH-ALK(1106-1620) fusion [endoplasmic reticulum membrane] (R-HSA-9702005)	0.615	10
UniProt:P35232 PHB1	2	PHB [cytosol] (R-HSA-5672944) PHB [mitochondrial inner membrane] (R-HSA-8953720)	0.615	13
UniProt:P16615 ATP2A2	2	ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903) ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962)	0.615	8
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.615	10
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.615	14
UniProt:P13010 XRCC5	4	XRCC5 [extracellular region] (R-HSA-6806530) XRCC5 [secretory granule lumen] (R-HSA-6801297) XRCC5 [cytosol] (R-HSA-3134849) XRCC5 [nucleoplasm] (R-HSA-58274)	0.615	13
UniProt:Q5T4S7 UBR4	5	UBR4 [ficolin-1-rich granule membrane] (R-HSA-6801503) UBR4 [tertiary granule membrane] (R-HSA-6801489) UBR4 [plasma membrane] (R-HSA-6801583) UBR4 [specific granule membrane] (R-HSA-6801492) UBR4 [cytosol] (R-HSA-976045)	0.615	10
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.615	13
UniProt:P04899 GNAI2	1	GNAI2 [plasma membrane] (R-HSA-55435)	0.615	10
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.615	13
UniProt:P07814 EPRS1	1	EPRS [cytosol] (R-HSA-379649)	0.615	8
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.615	12
UniProt:P06733 ENO1	1	ENO1 [cytosol] (R-HSA-71437)	0.615	13
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.615	13
UniProt:Q9UKM9 RALY			0.615	10
UniProt:O60884 DNAJA2	1	DNAJA2 [cytosol] (R-HSA-3371555)	0.615	9
UniProt:P17655 CAPN2	2	CAPN2 [cytosol] (R-HSA-8848630) CAPN2 [plasma membrane] (R-HSA-8863405)	0.615	13
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.615	10
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.615	13
UniProt:P06753 TPM3	3	TPM3 [cytosol] (R-HSA-390543) TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710837) TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710848)	0.615	14
UniProt:P26599 PTBP1	1	PTBP1 [nucleoplasm] (R-HSA-71923)	0.615	12
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.615	11
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.615	14
UniProt:P31944 CASP14	2	CASP14(6-146) [cytosol] (R-HSA-8847667) CASP14(153-242) [cytosol] (R-HSA-8847687)	0.615	10
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.615	15
UniProt:P14174 MIF	3	MIF [secretory granule lumen] (R-HSA-6803282) MIF [extracellular region] (R-HSA-212594) MIF [ficolin-1-rich granule lumen] (R-HSA-6803289)	0.615	11
UniProt:P57088 TMM33			0.615	15
UniProt:Q9BR76 COR1B			0.615	7
UniProt:P53618 COPB1	8	COPB1 [endoplasmic reticulum membrane] (R-HSA-6810955) COPB1 [ficolin-1-rich granule membrane] (R-HSA-6800972) COPB1 [tertiary granule membrane] (R-HSA-6800175) COPB1 [plasma membrane] (R-HSA-6806431) COPB1 [secretory granule membrane] (R-HSA-6800914) COPB1 [Golgi membrane] (R-HSA-6808735) COPB1 [transport vesicle] (R-HSA-6808736) COPB1 [cytosol] (R-HSA-199995)	0.615	7
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.615	15
UniProt:O14980 XPO1	2	XPO1 [nucleoplasm] (R-HSA-165529) XPO1 [cytosol] (R-HSA-165539)	0.615	16
UniProt:P61160 ACTR2	4	ACTR2 [azurophil granule lumen] (R-HSA-6798740) ACTR2 [extracellular region] (R-HSA-6806232) ACTR2 [ficolin-1-rich granule lumen] (R-HSA-6800937) ACTR2 [cytosol] (R-HSA-200810)	0.615	13
UniProt:P61163 ACTR1A	1	ACTR1A [cytosol] (R-HSA-380258)	0.615	6
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.615	14
UniProt:Q9ULV4 COR1C			0.615	16
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.615	9
UniProt:Q96N67 DOCK7	1	DOCK7 [cytosol] (R-HSA-1012970)	0.615	13
UniProt:O95433 AHSA1			0.615	8
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.615	13
UniProt:O95425 SVIL			0.615	12
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.615	14
UniProt:Q9P035 HACD3	1	PTPLAD1 [endoplasmic reticulum membrane] (R-HSA-5676074)	0.615	9
UniProt:Q9BUF5 TUBB6	6	TUBB6 [cytosol] (R-HSA-191698) TUBB6 [axonemal microtubule] (R-HSA-5610438) Polyglutamyl-TUBB6 [cytosol] (R-HSA-8867399) Polyglycyl-TUBB6 [cytosol] (R-HSA-8867396) TUBB6 unfolded [cytosol] (R-HSA-392780) TUBB6 folding intermediate [cytosol] (R-HSA-392787)	0.615	12
UniProt:P04075 ALDOA	6	ALDOA [platelet alpha granule lumen] (R-HSA-349738) ALDOA [tertiary granule lumen] (R-HSA-6801485) ALDOA [secretory granule lumen] (R-HSA-6801469) ALDOA [extracellular region] (R-HSA-349735) ALDOA [ficolin-1-rich granule lumen] (R-HSA-6801521) ALDOA [cytosol] (R-HSA-71492)	0.615	14
UniProt:Q8WWI1 LMO7	3	LMO7(1-1073)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713460) LMO7(1-1073)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713457) LMO7 [cytosol] (R-HSA-8862589)	0.615	12
UniProt:Q9UJW0 DCTN4	1	DCTN4 [cytosol] (R-HSA-2029070)	0.615	8
UniProt:P04080 CSTB	4	CSTB [tertiary granule lumen] (R-HSA-6801398) CSTB [secretory granule lumen] (R-HSA-6801394) CSTB [extracellular region] (R-HSA-6801567) CSTB [ficolin-1-rich granule lumen] (R-HSA-6801376)	0.615	12
UniProt:Q12904 AIMP1	1	AIMP1(1-312) [cytosol] (R-HSA-379609)	0.615	12
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.615	7
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [extracellular exosome] (R-HSA-8950304) HNRNPA2B1 [nucleoplasm] (R-HSA-71929)	0.615	14
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.615	13
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.615	12
UniProt:O43852 CALU	3	CALU [endoplasmic reticulum lumen] (R-HSA-350695) p-CALU [endoplasmic reticulum lumen] (R-HSA-8956931) CALU [extracellular region] (R-HSA-350739)	0.615	7
UniProt:O75340 PDCD6			0.615	6
UniProt:P30041 PRDX6	3	PRDX6 [extracellular region] (R-HSA-6806198) PRDX6 [azurophil granule lumen] (R-HSA-6798744) PRDX6 [cytosol] (R-HSA-3343670)	0.615	9
UniProt:P12956 XRCC6	5	XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [nucleoplasm] (R-HSA-58272)	0.615	13
UniProt:Q8WWM7 ATX2L			0.615	5
UniProt:A0FGR8 ESYT2	1	ESYT2 [endoplasmic reticulum membrane] (R-HSA-8857683)	0.615	9
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.615	16
UniProt:Q9NYL9 TMOD3	1	TMOD3 [cytosol] (R-HSA-217354)	0.615	13
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.615	12
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.615	16
UniProt:P46779 RPL28	1	RPL28 [cytosol] (R-HSA-72444)	0.615	14
UniProt:Q15233 NONO			0.615	14
UniProt:P46783 RPS10	2	RPS10 [nucleoplasm] (R-HSA-6798733) RPS10 [cytosol] (R-HSA-72325)	0.615	14
UniProt:P37802 TAGLN2	2	TAGLN2 [extracellular region] (R-HSA-8862999) TAGLN2 [cytosol] (R-HSA-8862962)	0.615	16
UniProt:P32119 PRDX2	2	p-T89-PRDX2 [cytosol] (R-HSA-8868574) PRDX2 [cytosol] (R-HSA-3341292)	0.615	14
UniProt:P43490 NAMPT	1	NAMPT [cytosol] (R-HSA-197188)	0.615	14
UniProt:Q13155 AIMP2	1	AIMP2 [cytosol] (R-HSA-379576)	0.615	14
UniProt:Q14257 RCN2			0.615	11
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.615	14
UniProt:Q14254 FLOT2	1	FLOT2 [plasma membrane] (R-HSA-8849895)	0.615	12
UniProt:Q13045 FLII			0.615	10
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.615	15
UniProt:P22061 PCMT1	1	PCMT1 [cytosol] (R-HSA-5676580)	0.615	14
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.615	14
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.615	11
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.615	15
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)	0.615	14
UniProt:Q08J23 NSUN2	1	NSUN2 [nucleoplasm] (R-HSA-6782382)	0.615	14
UniProt:P07384 CAPN1	4	CAPN1 [plasma membrane] (R-HSA-3828038) CAPN1 [cytosol] (R-HSA-3288367) CAPN1 [extracellular region] (R-HSA-6806485) CAPN1 [ficolin-1-rich granule lumen] (R-HSA-6801284)	0.604	7
UniProt:Q9BUN8 DERL1	1	DERL1 [endoplasmic reticulum membrane] (R-HSA-6781898)	0.604	4
UniProt:O15554 KCNN4	1	KCNN4 [plasma membrane] (R-HSA-977543)	0.602	5
UniProt:P11274 BCR	4	BCR [cytosol] (R-HSA-195200) BCR(1-584)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604524) p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839041) BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838979)	0.595	5
UniProt:P51572 BCAP31	6	BCAP31 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(238-246) [cytosol] (R-HSA-351912) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333)	0.583	9
UniProt:P13646 KRT13	1	KRT13 [cytosol] (R-HSA-6809591)	0.547	2
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.547	2
UniProt:Q96S97 MYADM			0.547	3
UniProt:P08582 MELTF	4	cleaved GPI-MELTF [extracellular region] (R-HSA-8941034) GPI-MELTF [plasma membrane] (R-HSA-8940716) p-MELTF [endoplasmic reticulum lumen] (R-HSA-8957070) MELTF [endoplasmic reticulum lumen] (R-HSA-8956701)	0.547	7
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.547	4
UniProt:Q9JIL4 NHRF3			0.544	7
UniProt:P55290 CDH13	1	CDH13 [plasma membrane] (R-HSA-419009)	0.527	7
UniProt:Q6PID8 KLD10			0.527	5
UniProt:Q9NQH7 XPP3			0.527	6
UniProt:Q5EB52 MEST			0.527	9
UniProt:Q9BU76 MMTAG2	3	MMTAG2 [secretory granule lumen] (R-HSA-6801073) MMTAG2 [extracellular region] (R-HSA-6806452) MMTAG2 [ficolin-1-rich granule lumen] (R-HSA-6801074)	0.527	6
UniProt:P62841 RPS15	2	RPS15 [nucleoplasm] (R-HSA-6798706) RPS15 [cytosol] (R-HSA-72335)	0.527	9
UniProt:P04632 CAPNS1	2	CAPNS1 [cytosol] (R-HSA-3288229) CAPNS1 [plasma membrane] (R-HSA-3828034)	0.527	4
UniProt:O00622 CCN1	2	p-CYR61 [endoplasmic reticulum lumen] (R-HSA-8956919) CYR61 [endoplasmic reticulum lumen] (R-HSA-5173201)	0.527	10
UniProt:P62873 GNB1	5	GNB1 [photoreceptor disc membrane] (R-HSA-55373) Unfolded GNB1 [cytosol] (R-HSA-6814200) Partially folded GNB1 [cytosol] (R-HSA-8850526) GNB1 [plasma membrane] (R-HSA-164347) GNB1 [cytosol] (R-HSA-6814412)	0.527	10
UniProt:Q9Y3U8 RPL36	1	RPL36 [cytosol] (R-HSA-72464)	0.527	7
UniProt:P05109 S100A8	3	S100A8 [cytosol] (R-HSA-9626834) S100A8 [secretory granule lumen] (R-HSA-6804772) S100A8 [extracellular region] (R-HSA-5432846)	0.527	7
UniProt:P05121 SERPINE1	3	SERPINE1 [plasma membrane] (R-HSA-158922) SERPINE1 [platelet alpha granule lumen] (R-HSA-114649) SERPINE1 [extracellular region] (R-HSA-158797)	0.527	10
UniProt:P0CG39 POTEJ			0.527	9
UniProt:Q92747 ARPC1A	1	ARPC1A [cytosol] (R-HSA-200807)	0.527	10
UniProt:P47914 RPL29	1	RPL29 [cytosol] (R-HSA-72446)	0.527	10
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.527	4
UniProt:P62273 RPS29	2	RPS29 [nucleoplasm] (R-HSA-6798725) RPS29 [cytosol] (R-HSA-72367)	0.527	9
UniProt:P56537 IF6			0.527	7
UniProt:P08107 HSP71			0.527	4
UniProt:A8MQ03 CRTP1			0.527	3
UniProt:P09382 LGALS1	2	p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003) LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711)	0.527	10
UniProt:Q9BQE3 TUBA1C	9	AcK-TUBA1C [cytosol] (R-HSA-5618314) Ac K40 TUBA1C [axonemal microtubule] (R-HSA-5624856) TUBA1C folding intermediate [cytosol] (R-HSA-392798) TUBA1C unfolded [cytosol] (R-HSA-392772) L-isoglutamyl polyglycyl-TUBA1C [cytosol] (R-HSA-8867405) Polyglutamyl-TUBA1C [cytosol] (R-HSA-8867401) TUBA1C(1-448) [cytosol] (R-HSA-8955579) TUBA1C [axonemal microtubule] (R-HSA-5610439) TUBA1C [cytosol] (R-HSA-190590)	0.527	6
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.527	10
UniProt:O43852-1 CALU			0.524	2
UniProt:P07099 EPHX1	1	EPHX1 [endoplasmic reticulum membrane] (R-HSA-5694132)	0.519	5
UniProt:Q9H7E9 CH033			0.519	5
UniProt:Q96KC8 DNJC1			0.519	7
UniProt:P55036 PSMD4	2	PSMD4 [nucleoplasm] (R-HSA-174330) PSMD4 [cytosol] (R-HSA-68800)	0.519	7
UniProt:O00400 SLC33A1	4	SLC33A1 A110P [Golgi membrane] (R-HSA-5649754) SLC33A1 S113R [Golgi membrane] (R-HSA-5649751) SLC33A1 Y366* [Golgi membrane] (R-HSA-5649750) SLC33A1 [Golgi membrane] (R-HSA-727745)	0.519	6
UniProt:Q9NYY8 FASTKD2	1	FASTKD2 [mitochondrial matrix] (R-HSA-9837146)	0.519	5
UniProt:Q9UHB9 SRP68	1	SRP68 [cytosol] (R-HSA-445234)	0.519	7
UniProt:P58335 ANTXR2			0.519	2
UniProt:O75127 PTCD1			0.519	3
UniProt:O60869 EDF1			0.519	3
UniProt:Q9UHI6 DDX20	2	DDX20 [nucleoplasm] (R-HSA-191847) DDX20 [cytosol] (R-HSA-191838)	0.519	5
UniProt:Q9HCC0 MCCC2	2	MCCC2 [cytosol] (R-HSA-3323134) MCCC2 [mitochondrial matrix] (R-HSA-70769)	0.519	5
UniProt:Q96Q45 TM237			0.519	4
UniProt:Q6UWZ7 ABRAXAS1	1	p-S406-FAM175A [nucleoplasm] (R-HSA-5682575)	0.519	3
UniProt:Q53EZ4 CEP55			0.519	5
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.519	7
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.519	9
UniProt:Q9BYJ9 YTHD1			0.519	5
UniProt:Q9NQX7 ITM2C			0.519	2
UniProt:Q6PI48 DARS2	1	DARS2 [mitochondrial matrix] (R-HSA-379679)	0.519	5
UniProt:Q9UJY5 GGA1	2	GGA1 [early endosome membrane] (R-HSA-8854136) GGA1 [endosome membrane] (R-HSA-5692930)	0.519	6
UniProt:P07203 GPX1	2	L-selenocysteine residue-GPX1 [cytosol] (R-HSA-71673) L-selenoC49-GPX1 [mitochondrial matrix] (R-HSA-3322994)	0.519	3
UniProt:Q9P289 STK26	3	MST4(306-416) [cytosol] (R-HSA-351903) MST4(1-305) [cytosol] (R-HSA-351855) MST4 [cytosol] (R-HSA-351918)	0.519	6
UniProt:P41227 NAA10			0.519	5
UniProt:Q9NP61 ARFGAP3	1	ARFGAP3 [cytosol] (R-HSA-6807740)	0.519	8
UniProt:P08559 PDHA1	1	PDHA1 [mitochondrial matrix] (R-HSA-69966)	0.519	5
UniProt:Q92552 MRPS27	1	MRPS27 [mitochondrial inner membrane] (R-HSA-5368214)	0.519	5
UniProt:P45880 VDAC2	2	PolyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-6783185) VDAC2 [mitochondrial outer membrane] (R-HSA-5696880)	0.519	5
UniProt:P19367 HK1	4	HK1 T680S [cytosol] (R-HSA-5621880) HK1 H577_C672del [cytosol] (R-HSA-5621873) HK1 L529S [cytosol] (R-HSA-5621861) HK1 [cytosol] (R-HSA-70395)	0.519	5
UniProt:O95292 VAPB	2	VAPB [Golgi membrane] (R-HSA-9715115) VAPB [endoplasmic reticulum membrane] (R-HSA-429718)	0.519	7
UniProt:P13804 ETFA	1	ETFA(1-?) [mitochondrial matrix] (R-HSA-169262)	0.519	5
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.519	7
UniProt:Q6P444 MTFR2			0.519	2
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.519	4
UniProt:O15126 SCAMP1	2	SCAMP1 [plasma membrane] (R-HSA-6806161) SCAMP1 [specific granule membrane] (R-HSA-6806140)	0.519	7
UniProt:P63162 SNRPN	1	Me2-R108,R112-SNRPN [nucleoplasm] (R-HSA-8865931)	0.519	6
UniProt:Q96HY6 DDRGK1	1	DDRGK1 [endoplasmic reticulum membrane] (R-HSA-9714335)	0.519	4
UniProt:Q13057 COASY	1	COASY [mitochondrial outer membrane] (R-HSA-196735)	0.519	7
UniProt:Q7L2E3 DHX30			0.519	5
UniProt:P29353 SHC1	5	SHC1 [cytosol] (R-HSA-74680) p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.519	6
UniProt:O75330 HMMR	2	HMMR [plasma membrane] (R-HSA-2160885) HMMR [cytosol] (R-HSA-8861624)	0.519	7
UniProt:Q6P6B1 ERIC5			0.508	4
UniProt:Q14314 FGL2	2	FGL2 [extracellular region] (R-HSA-6801586) FGL2 [ficolin-1-rich granule lumen] (R-HSA-6801499)	0.508	6
UniProt:Q8WTP9 XAGE3			0.508	4
UniProt:Q9Y3X0 CCDC9			0.508	4
UniProt:O60831 PRAF2			0.508	4
UniProt:Q8WWA1 TMM40			0.508	4
UniProt:P0CG30 GSTT2B	1	GSTT2B [cytosol] (R-HSA-3302073)	0.508	4
UniProt:Q7Z5V6 PPR32			0.508	3
UniProt:P17026 ZNF22			0.508	2
UniProt:Q9NSC7 ST6GALNAC1	1	ST6GALNAC1 [Golgi membrane] (R-HSA-981856)	0.508	5
UniProt:O95154 AKR7A3	1	AKR7A3 [cytosol] (R-HSA-5423652)	0.508	4
UniProt:Q9BXU7 USP26	1	USP26 [nucleoplasm] (R-HSA-5696887)	0.508	4
UniProt:P29762 CRABP1	1	SUMO-K-CRABP1 [cytosol] (R-HSA-5334807)	0.508	4
UniProt:P51790-2 CLCN3			0.499	2
UniProt:Q9HBW0 LPAR2	1	LPAR2 [plasma membrane] (R-HSA-419393)	0.499	3
UniProt:P11233 RALA	2	RALA [cytosol] (R-HSA-170988) GGC-RALA [cytoplasmic vesicle membrane] (R-HSA-1458479)	0.483	8
UniProt:Q99959 PKP2	2	PKP2 [cornified envelope] (R-HSA-8847734) PKP2 [plasma membrane] (R-HSA-6814393)	0.483	12
UniProt:Q16891 IMMT	1	IMMT (MIC60) [mitochondrial inner membrane] (R-HSA-8949569)	0.483	6
UniProt:Q9NQG5 RPRD1B	1	RPRD1B [nucleoplasm] (R-HSA-6814894)	0.483	7
UniProt:Q8WUP2 FBLIM1	1	FBLIM1 [cytosol] (R-HSA-430301)	0.483	3
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.483	9
UniProt:Q9UDY2 TJP2	4	TJP2 [cytosol] (R-HSA-2064412) TJP2 [nucleoplasm] (R-HSA-2064410) TJP2 [plasma membrane] (R-HSA-351862) TJP2(?-?) [plasma membrane] (R-HSA-351897)	0.483	13
UniProt:P14868 DARS1	1	DARS [cytosol] (R-HSA-379605)	0.483	12
UniProt:P14625 HSP90B1	4	HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) HSP90B1 [extracellular region] (R-HSA-3221653) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.483	12
UniProt:P68371 TUBB4B	8	TUBB4B folding intermediate [cytosol] (R-HSA-392788) TUBB4B unfolded [cytosol] (R-HSA-392779) Polyglycyl-TUBB4B [cytosol] (R-HSA-8867452) Polyglutamyl-TUBB4B [cytosol] (R-HSA-8867427) TUBB4B [extracellular region] (R-HSA-6806178) TUBB4B [azurophil granule lumen] (R-HSA-6799347) TUBB4B [axonemal microtubule] (R-HSA-5610441) TUBB4B [cytosol] (R-HSA-191702)	0.483	12
UniProt:P24666 PPAC			0.483	9
UniProt:Q14103 HNRNPD	1	HNRNPD [nucleoplasm] (R-HSA-71935)	0.483	6
UniProt:Q16527 CSRP2			0.483	6
UniProt:P62829 RPL23	1	RPL23 [cytosol] (R-HSA-72430)	0.483	12
UniProt:Q16763 UBE2S	4	Ub-C95-UBE2S [cytosol] (R-HSA-8864164) Ub-C95-UBE2S [nucleoplasm] (R-HSA-8864181) UBE2S [nucleoplasm] (R-HSA-8852051) UBE2S [cytosol] (R-HSA-947622)	0.483	3
UniProt:Q16643 DBN1	1	DBN1 [cytosol] (R-HSA-9714666)	0.483	13
UniProt:P36542 ATP5F1C	1	ATP5C1 [mitochondrial matrix] (R-HSA-164577)	0.483	12
UniProt:P11586 MTHFD1	1	MTHFD1 [cytosol] (R-HSA-200641)	0.483	12
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.483	5
UniProt:P14618 PKM	3	PKM [secretory granule lumen] (R-HSA-6801401) PKM [extracellular region] (R-HSA-6806491) PKM [ficolin-1-rich granule lumen] (R-HSA-6801387)	0.483	12
UniProt:P52907 CAPZA1	2	CAPZA1(265-276) [extracellular region] (R-HSA-879421) CAPZA1 [cytosol] (R-HSA-879363)	0.483	14
UniProt:P13645 KRT10	1	KRT10 [cytosol] (R-HSA-6809604)	0.483	6
UniProt:P38606 ATP6V1A	1	ATP6V1A [cytosol] (R-HSA-912602)	0.483	12
UniProt:Q9Y3L5 RAP2C	2	RAP2C [plasma membrane] (R-HSA-6804983) RAP2C [tertiary granule membrane] (R-HSA-6804975)	0.483	9
UniProt:P21266 GSTM3	1	GSTM3 [cytosol] (R-HSA-3302077)	0.483	6
UniProt:P22234 PAICS	1	PAICS [cytosol] (R-HSA-62502)	0.483	7
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.483	8
UniProt:P61604 HSPE1	1	HSPE1 [cytosol] (R-HSA-9714750)	0.483	14
UniProt:P40926 MDH2	1	MDH2 [mitochondrial matrix] (R-HSA-70977)	0.483	5
UniProt:P35580 MYH10	1	MYH10 [cytosol] (R-HSA-419174)	0.483	13
UniProt:P62937 PPIA	5	PPIA [extracellular exosome] (R-HSA-6801538) PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [extracellular region] (R-HSA-173646) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [cytosol] (R-HSA-173123)	0.483	12
UniProt:Q13148 TADBP			0.483	5
UniProt:P13797 PLST			0.483	8
UniProt:P58546 MTPN			0.483	8
UniProt:Q8N3E9 PLCD3	1	PLCD3 [plasma membrane] (R-HSA-2023882)	0.483	7
UniProt:Q9UPN3 MACF1			0.483	5
UniProt:Q15417 CNN3			0.483	11
UniProt:Q14444 CAPR1			0.483	4
UniProt:Q15654 TRIP6			0.483	9
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.483	11
UniProt:Q9NRF8 CTPS2	1	CTPS2 [cytosol] (R-HSA-504053)	0.483	8
UniProt:P60866 RPS20	2	RPS20 [nucleoplasm] (R-HSA-6798727) RPS20 [cytosol] (R-HSA-72349)	0.483	12
UniProt:P55265 ADAR	2	ADAR1 [cytosol] (R-HSA-9835955) ADAR [nucleoplasm] (R-HSA-53939)	0.483	14
UniProt:P02538 KRT6A	1	KRT6A [cytosol] (R-HSA-6809654)	0.483	5
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [cytosol] (R-HSA-380285) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [extracellular region] (R-HSA-6806223)	0.483	12
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.483	11
UniProt:Q14203 DCTN1	7	DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711969) DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711960) DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] (R-HSA-9701997) DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711959) DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711953) DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711962) DCTN1 [cytosol] (R-HSA-535580)	0.483	5
UniProt:Q13131 PRKAA1	3	p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206) p-T183-PRKAA1 [cytosol] (R-HSA-380964) PRKAA1 [cytosol] (R-HSA-380935)	0.483	3
UniProt:Q13492 PICALM	3	PICALM [Golgi membrane] (R-HSA-434341) PICALM [cytoplasmic vesicle membrane] (R-HSA-429812) PICALM [cytosol] (R-HSA-8867593)	0.483	7
UniProt:O94905 ERLIN2	3	ERLIN2 [endoplasmic reticulum membrane] (R-HSA-8866520) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane] (R-HSA-8853122) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane] (R-HSA-8853148)	0.483	7
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [extracellular region] (R-HSA-3221939)	0.483	8
UniProt:P27708 CAD	1	CAD [cytosol] (R-HSA-73452)	0.483	13
UniProt:Q14697 GANAB	1	GANAB [endoplasmic reticulum lumen] (R-HSA-532674)	0.483	12
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.483	12
UniProt:P62917 RPL8	3	3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976) RPL8 [nucleoplasm] (R-HSA-9630985) RPL8 [cytosol] (R-HSA-72490)	0.483	12
UniProt:Q99829 CPNE1	2	CPNE1 [plasma membrane] (R-HSA-5215998) CPNE1 [azurophil granule membrane] (R-HSA-6799152)	0.483	9
UniProt:P04844 RPN2	1	RPN2 [endoplasmic reticulum membrane] (R-HSA-264937)	0.483	5
UniProt:P35241 RDX	2	p-T564-RDX [cytosol] (R-HSA-9662922) RDX [cytosol] (R-HSA-437348)	0.483	4
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.483	12
UniProt:Q96S55 WRIP1			0.483	8
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.483	2
UniProt:Q96RT1 ERBIN	1	ERBIN [plasma membrane] (R-HSA-1358718)	0.483	7
UniProt:Q8WX93 PALLD			0.483	11
UniProt:Q14669 TRIP12	1	TRIP12 [cytosol] (R-HSA-976046)	0.483	6
UniProt:P50990 CCT8	5	CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [cytosol] (R-HSA-390449)	0.483	14
UniProt:P00492 HPRT1	4	HPRT1 [cytosol] (R-HSA-56639) HPRT1 D194N [cytosol] (R-HSA-9734269) HPRT1 G70E [cytosol] (R-HSA-9734286) HPRT1 G140D [cytosol] (R-HSA-9734264)	0.483	7
UniProt:P46379 BAG6	1	BAG6 [cytosol] (R-HSA-201567)	0.483	8
UniProt:P15880 RPS2	3	RPS2 [nucleoplasm] (R-HSA-6790655) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [cytosol] (R-HSA-72347)	0.483	12
UniProt:P83731 RPL24	1	RPL24 [cytosol] (R-HSA-72434)	0.483	12
UniProt:P62854 RPS26	2	RPS26 [nucleoplasm] (R-HSA-6798708) RPS26 [cytosol] (R-HSA-72359)	0.483	7
UniProt:Q04637 EIF4G1	2	p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762) EIF4G1 [cytosol] (R-HSA-72584)	0.483	7
UniProt:P49411 TUFM	2	TUFM [mitochondrial matrix] (R-HSA-5389846) TUFM [mitochondrial outer membrane] (R-HSA-9754777)	0.483	12
UniProt:P48444 ARCN1	4	ARCN1 [endoplasmic reticulum membrane] (R-HSA-6810948) ARCN1 [Golgi membrane] (R-HSA-6808714) ARCN1 [transport vesicle] (R-HSA-6808717) ARCN1 [cytosol] (R-HSA-199980)	0.483	5
UniProt:Q04760 GLO1	1	GLO1 [cytosol] (R-HSA-5694127)	0.483	13
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.483	7
UniProt:Q9BS26 ERP44	2	ERP44 [extracellular region] (R-HSA-6806302) ERP44 [specific granule lumen] (R-HSA-6799567)	0.483	4
UniProt:P49773 HINT1			0.483	11
UniProt:Q14315 FLNC	1	FLNC [cytosol] (R-HSA-201585)	0.483	13
UniProt:Q14677 CLINT1	1	CLINT1 [cytosol] (R-HSA-429811)	0.483	8
UniProt:Q15645 PCH2