Negative regulation of activity of TFAP2 (AP-2) family transcription factors

Stable Identifier
R-HSA-8866904
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Transcriptional activity of TFAP2 (AP-2) transcription factor family homo- and heterodimers in inhibited by binding of KCTD1 or KCTD15 to the AP-2 transactivation domain (Ding et al. 2009, Zarelli and Dawid 2013). Transcriptional activity of TFAP2A, TFAP2B and TFAP2C is also negatively regulated by SUMOylation mediated by UBE2I (UBC9) (Eloranta and Hurst 2002, Berlato et al. 2011, Impens et al. 2014, Bogachek et al. 2014). Binding of the tumor suppressor WWOX to TFAP2C inhibits TFAP2C translocation to the nucleus (Aqeilan et al. 2004). Transcription of the TFAP2A gene may be inhibited by CREB and E2F1 (Melnikova et al. 2010).

Literature References
PubMed ID Title Journal Year
19115315 The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation

Ding, X, Luo, C, Zhou, J, Zhong, Y, Hu, X, Zhou, F, Ren, K, Gan, L, He, A, Zhu, J, Gao, X, Zhang, J

J. Cell. Biochem. 2009
12072434 Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo

Eloranta, JJ, Hurst, HC

J. Biol. Chem. 2002
24835590 Sumoylation pathway is required to maintain the basal breast cancer subtype

Bogachek, MV, Chen, Y, Kulak, MV, Woodfield, GW, Cyr, AR, Park, JM, Spanheimer, PM, Li, Y, Li, T, Weigel, RJ

Cancer Cell 2014
23382213 Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2

Zarelli, VE, Dawid, IB

Proc. Natl. Acad. Sci. U.S.A. 2013
15548692 Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor

Aqeilan, RI, Palamarchuk, A, Weigel, RJ, Herrero, JJ, Pekarsky, Y, Croce, CM

Cancer Res. 2004
20805990 CREB inhibits AP-2alpha expression to regulate the malignant phenotype of melanoma

Melnikova, VO, Dobroff, AS, Zigler, M, Villares, GJ, Braeuer, RR, Wang, H, Huang, L, Bar-Eli, M

PLoS ONE 2010
21375726 Alternative TFAP2A isoforms have distinct activities in breast cancer

Berlato, C, Chan, KV, Price, AM, Canosa, M, Scibetta, AG, Hurst, HC

Breast Cancer Res. 2011
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
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