TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

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R-HSA-8866910
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Homo sapiens
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TFAP2A and TFAP2C directly stimulate transcription of the estrogen receptor ESR1 gene (McPherson and Weigel 1999). TFAP2A expression correlates with ESR1 expression in breast cancer, and TFAP2C is frequently overexpressed in estrogen-positive breast cancer and endometrial cancer (deConinck et al. 1995, Turner et al. 1998). TFAP2A, TFAP2C, as well as TFAP2B can directly stimulate the expression of ERBB2, another important breast cancer gene (Bosher et al. 1996). Association of TFAP2A with the YY1 transcription factor significantly increases the ERBB2 transcription rate (Begon et al. 2005). In addition to ERBB2, the expression of another receptor tyrosine kinase, KIT, is also stimulated by TFAP2A and TFAP2B (Huang et al. 1998), while the expression of the VEGF receptor tyrosine kinase ligand VEGFA is repressed by TFAP2A (Ruiz et al. 2004, Li et al. 2012). TFAP2A stimulates transcription of the transforming growth factor alpha (TGFA) gene (Wang et al. 1997). TFAP2C regulates EGFR expression in luminal breast cancer (De Andrade et al. 2016). In placenta, TFAP2A and TFAP2C directly stimulate transcription of both subunits of the human chorionic gonadotropin, CGA and CGB (Johnson et al. 1997, LiCalsi et al. 2000).

Literature References
PubMed ID Title Journal Year
9182571 Regulation of the human chorionic gonadotropin alpha- and beta-subunit promoters by AP-2

Johnson, W, Albanese, C, Handwerger, S, Williams, T, Pestell, RG, Jameson, JL

J. Biol. Chem. 1997
15870067 Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells

Begon, DY, Delacroix, L, Vernimmen, D, Jackers, P, Winkler, R

J. Biol. Chem. 2005
10497269 AP2alpha and AP2gamma: a comparison of binding site specificity and trans-activation of the estrogen receptor promoter and single site promoter constructs

McPherson, LA, Weigel, RJ

Nucleic Acids Res. 1999
9687504 Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis

Huang, S, Jean, D, Luca, M, Tainsky, MA, Bar-Eli, M

EMBO J. 1998
8895516 A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma

Bosher, JM, Totty, NF, Hsuan, JJ, Williams, T, Hurst, HC

Oncogene 1996
7891714 Transcriptional regulation of estrogen receptor in breast carcinomas

deConinck, EC, McPherson, LA, Weigel, RJ

Mol. Cell. Biol. 1995
26832794 EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib

De Andrade, JP, Park, JM, Gu, VW, Woodfield, GW, Kulak, MV, Lorenzen, AW, Wu, VT, Van Dorin, SE, Spanheimer, PM, Weigel, RJ

Mol. Cancer Ther. 2016
14744778 Activator protein 2alpha inhibits tumorigenicity and represses vascular endothelial growth factor transcription in prostate cancer cells

Ruiz, M, Pettaway, C, Song, R, Stoeltzing, O, Ellis, L, Bar-Eli, M

Cancer Res. 2004
22735262 CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression

Li, Q, Pan, H, Guan, L, Su, D, Ma, X

Biochem. Biophys. Res. Commun. 2012
9850080 Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways

Turner, BC, Zhang, J, Gumbs, AA, Maher, MG, Kaplan, L, Carter, D, Glazer, PM, Hurst, HC, Haffty, BG, Williams, T

Cancer Res. 1998
10648798 AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin

LiCalsi, C, Christophe, S, Steger, DJ, Buescher, M, Fischer, W, Mellon, PL

Nucleic Acids Res. 2000
9162057 Transcription factor AP-2 controls transcription of the human transforming growth factor-alpha gene

Wang, D, Shin, TH, Kudlow, JE

J. Biol. Chem. 1997
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