TFAP2 (AP-2) family regulates transcription of cell cycle factors

Stable Identifier
R-HSA-8866911
Type
Pathway
Species
Homo sapiens
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Summation

TFAP2A and TFAP2C play opposing roles in transcriptional regulation of the CDKN1A (p21) gene locus. While TFAP2A stimulates transcription of the CDKN1A cyclin-dependent kinase inhibitor (Zeng et al. 1997, Williams et al. 2009, Scibetta et al. 2010), TFAP2C, in cooperation with MYC and histone demethylase KDM5B, represses CDKN1A transcription (Williams et al. 2009, Scibetta et al. 2010, Wong et al. 2012).

Literature References
PubMed ID Title Journal Year
22371483 Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A)

Wong, PP, Miranda, F, Chan, KV, Berlato, C, Hurst, HC, Scibetta, AG

Mol. Cell. Biol. 2012
8988173 AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression

Zeng, YX, Somasundaram, K, el-Deiry, WS

Nat. Genet. 1997
19798054 AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene

Williams, CM, Scibetta, AG, Friedrich, JK, Canosa, M, Berlato, C, Moss, CH, Hurst, HC

EMBO J. 2009
21084835 Dual association by TFAP2A during activation of the p21cip/CDKN1A promoter

Scibetta, AG, Wong, PP, Chan, KV, Canosa, M, Hurst, HC

Cell Cycle 2010
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Orthologous Events
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