EGFR phosphorylates EPS15

Stable Identifier
R-HSA-8867041
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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EPS15 is phosphorylated at Y849 by activated EGFR (Confalonieri et al, 2000). While the roles of phosphorylation and ubiquitination in EGFR endocytosis are unclear, emerging evidence suggests that EPS15 phosphorylation may target the activated EGFR complex for endocytosis through a clathrin-mediated route, while dephosphorylation at Y849 may direct the receptor complex into a clathrin-independent route (Confalonieri et al, 2002; de Melker et al, 2004; Li et al, 2015; reviewed in van Bergen en Henegouwen, 2009).

Literature References
PubMed ID Title Journal Year
15465819 Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment

de Melker, AA, van der Horst, G, Borst, J

J. Biol. Chem. 2004
19814798 Eps15: a multifunctional adaptor protein regulating intracellular trafficking

van Bergen En Henegouwen, PM

Cell Commun. Signal 2009
10953014 Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis

Confalonieri, S, Salcini, AE, Puri, C, Tacchetti, C, Di Fiore, PP

J. Cell Biol. 2000
25263444 Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation

Li, MY, Lai, PL, Chou, YT, Chi, AP, Mi, YZ, Khoo, KH, Chang, GD, Wu, CW, Meng, TC, Chen, GC

Oncogene 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created