EGFR binds EPS15, EPN1, EPS15L1

Stable Identifier
R-HSA-8867044
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

EH-containing proteins such as EPS15, EPN1 and EPS15L1 are required for the endocytosis of ligand-activated EGFR (Confalonieri et al, 2000; Huang et al, 2004; reviewed in van Bergen en Henegouwen, 2009). EPS15 and EPN1 bind components of the clathrin coated pit through DPF motifs and likely bind to EGFR through the ubiquitin interacting motifs (UIMs). In this way EH proteins may help cluster activated EGFR into nascent clathrin-coated pits (Kazazic et al, 2009; Benmerah et al, 2000; reviewed in van Bergen en Henegouwen, 2009). Note, however, that EH-containing proteins are also involved in the clathrin-independent endocytosis of EGFR (Sigismund et al, 2005)

Literature References
PubMed ID Title Journal Year
10652316 Mapping of Eps15 domains involved in its targeting to clathrin-coated pits

Benmerah, A, Poupon, V, Cerf-Bensussan, N, Dautry-Varsat, A

J. Biol. Chem. 2000
19814798 Eps15: a multifunctional adaptor protein regulating intracellular trafficking

van Bergen En Henegouwen, PM

Cell Commun. Signal 2009
14985334 Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference

Huang, F, Khvorova, A, Marshall, W, Sorkin, A

J. Biol. Chem. 2004
10953014 Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis

Confalonieri, S, Salcini, AE, Puri, C, Tacchetti, C, Di Fiore, PP

J. Cell Biol. 2000
19054389 Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits

Kazazic, M, Bertelsen, V, Pedersen, KW, Vuong, TT, Grandal, MV, Rødland, MS, Traub, LM, Stang, E, Madshus, IH

Traffic 2009
15701692 Clathrin-independent endocytosis of ubiquitinated cargos

Sigismund, S, Woelk, T, Puri, C, Maspero, E, Tacchetti, C, Transidico, P, Di Fiore, PP, Polo, S

Proc Natl Acad Sci U S A 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created