PTPN3 dephosphorylates EPS15

Stable Identifier
R-HSA-8867047
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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While the roles of EGFR and EPS15 phosphorylation and ubiquitination are not completely clear, recent evidence supports the idea that EGFR-mediated phosphorylation of EPS15 promotes the clustering of the activated receptor into clathrin-coated pits, while the dephosphorylated EPS15 targets EGFR for endocytosis through a caveolin-and lipid raft-dependent route (reviewed in van Bergen en Henegouwen, 2009). Consistent with this, overexpression of the phosphatase PTPN3, which dephosphorylates EPS15 in vitro and in vivo, promotes the internalization of EGFR into caveolin-enriched structures and targets it for lysosomal degradation (Li et al, 2015).

Literature References
PubMed ID Title Journal Year
25263444 Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation

Li, MY, Lai, PL, Chou, YT, Chi, AP, Mi, YZ, Khoo, KH, Chang, GD, Wu, CW, Meng, TC, Chen, GC

Oncogene 2015
19814798 Eps15: a multifunctional adaptor protein regulating intracellular trafficking

van Bergen En Henegouwen, PM

Cell Commun. Signal 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created