Reactome | Polyglutamyl-TUBA4A [cytosol]

Polyglutamyl-TUBA4A [cytosol]

Stable Identifier

R-HSA-8867386

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBA4A, Tubulin alpha-4A chain, alpha tubulin -1, Alpha-tubulin 1

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - CCPs deglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA4A [cytosol] (Homo sapiens)
    - Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA4A [cytosol] (Homo sapiens)
    - TTLLs polyglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA4A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P68366 TUBA4A

Gene Names

TUBA4A, TUBA1

Chain

chain:1-448

Reference Genes

BioGPS Gene:7277 TUBA4A

COSMIC (genes):TUBA4A TUBA4A

CTD Gene:7277 TUBA4A

dbSNP Gene:7277 TUBA4A

ENSEMBL:ENSG00000127824 TUBA4A

ENSEMBL_homo_sapiens_GENE:ENSG00000127824.15 TUBA4A

HGNC:12407 TUBA4A

KEGG Gene (Homo sapiens):7277 TUBA4A

Monarch:7277 TUBA4A

NCBI Gene:7277 TUBA4A

OMIM:191110 TUBA4A

UCSC:P68366 TUBA4A

Reference Transcript

Other Identifiers

11716459_at

11716460_x_at

212242_PM_at

212242_at

2528412

2528417

2528418

2600069

2600070

2600073

2600075

2600076

2600080

2600081

330_s_at

36591_at

61786_at

7277

8059177

A_23_P154065

A_23_P154070

GE505003

GE86661

GO:0000166

GO:0000226

GO:0000278

GO:0003824

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0015630

GO:0016787

GO:0019901

GO:0043226

GO:0046872

GO:0070062

HMNXSV003013201

HMNXSV003042752

Hs.75318.0.S1_3p_at

Hs.75318.0.S1_3p_x_at

ILMN_1784300

PH_hs_0028966

PH_hs_0031317

TC02002793.hg

X06956_at

Participates

as a candidate of

Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)

Other forms of this molecule

TUBA4A [cytosol]

TUBA4A [axonemal microtubule]

TUBA4A [extracellular region]

L-isoglutamyl polyglycyl-TUBA4A [cytosol]

TUBA4A unfolded [cytosol]

TUBA4A folding intermediate [cytosol]

Ac K40 TUBA4A [axonemal microtubule]

AcK-TUBA4A [cytosol]

Inferred To

Homologues of Polyglutamyl-TUBA4A [cytosol] (Dictyostelium discoideum)

Homologues of Polyglutamyl-TUBA4A [cytosol] (Plasmodium falciparum)

Homologues of Polyglutamyl-TUBA4A [cytosol] (Xenopus tropicalis)

TUBA4A [cytosol] (Canis familiaris)

TUBA4A [cytosol] (Sus scrofa)

tuba4b [cytosol] (Xenopus tropicalis)

Polyglutamyl-TUBA4A [cytosol] (Bos taurus)

Polyglutamyl-TUBA4A [cytosol] (Dictyostelium discoideum)

Polyglutamyl-TUBA4A [cytosol] (Mus musculus)

Polyglutamyl-TUBA4A [cytosol] (Plasmodium falciparum)

Polyglutamyl-TUBA4A [cytosol] (Rattus norvegicus)

Polyglutamyl-TUBA4A [cytosol] (Xenopus tropicalis)

Modified Residues

Name

L-isoglutamyl-polyglutamic acid at unknown position

PsiMod Name

L-isoglutamyl-polyglutamic acid

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.

Cross References

RefSeq

NP_005991.1, NP_001265481.1

Guide to Pharmacology - Targets

2639

OpenTargets

ENSG00000127824

HPA

ENSG00000127824-TUBA4A

GeneCards

P68366

Ensembl

ENST00000392088, ENSG00000127824, ENSP00000375938, ENST00000248437, ENSP00000248437

PRO

P68366

Pharos - Targets

P68366

HMDB Protein

HMDBP08598

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.643	4
UniProt:P30622 CLIP1	3	CLIP1(1-1083)-p-6Y LTK(488-864) fusion [plasma membrane] (R-HSA-9842573) CLIP1(1-1083)-LTK(488-864) fusion [plasma membrane] (R-HSA-9842572) CLIP1 [cytosol] (R-HSA-377732)	0.618	3
UniProt:Q99426 TBCB	1	TBCB [cytosol] (R-HSA-379546)	0.589	2
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	5
UniProt:Q15398 DLGAP5	1	DLGAP5 [cytosol] (R-HSA-264452)	0.527	2
UniProt:Q9Y337 KLK5	4	KLK5 [extracellular region] (R-HSA-8849629) proKLK5 [extracellular region] (R-HSA-8849836) KLK5 propeptide [extracellular region] (R-HSA-8849839) KLK5 [cytosol] (R-HSA-8934778)	0.527	3
UniProt:Q8N0Z6 TTC5	3	TTC5 [nucleoplasm] (R-HSA-6804264) p-S203-TTC5 [nucleoplasm] (R-HSA-6804261) p-S203,S221-TTC5 [nucleoplasm] (R-HSA-6804259)	0.527	2
UniProt:P20309 CHRM3	1	CHRM3 [plasma membrane] (R-HSA-399994)	0.527	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	3
UniProt:Q07954 LRP1	2	LRP1 [plasma membrane] (R-HSA-1454844) LRP1 [endocytic vesicle membrane] (R-HSA-2230981)	0.527	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	5
UniProt:P46059 SLC15A1	1	SLC15A1 [plasma membrane] (R-HSA-428022)	0.527	2
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.527	2
UniProt:Q8N307 MUC20	19	Core 8 (MUC20) [Golgi lumen] (R-HSA-1462329) Core 2S (MUC20) [Golgi lumen] (R-HSA-6786382) Core 5 (MUC20) [Golgi lumen] (R-HSA-1462128) Core 4 (MUC20) [Golgi lumen] (R-HSA-1462266) Core 3 (MUC20) [Golgi lumen] (R-HSA-1462344) Core 7 (MUC20) [Golgi lumen] (R-HSA-1462236) extended Core 6 (MUC20) [Golgi lumen] (R-HSA-1967016) Core 6 (MUC20) [Golgi lumen] (R-HSA-1462247) MUC20 [Golgi lumen] (R-HSA-913634) Disialyl T-antigen (MUC20) [Golgi lumen] (R-HSA-1463482) Sialyl T-antigen (MUC20) [Golgi lumen] (R-HSA-1463469) Sialyl-2,3 T-antigen (MUC20) [Golgi lumen] (R-HSA-1463479) T-antigen (MUC20) [Golgi lumen] (R-HSA-1462188) Sialyl Tn antigen (MUC20) [Golgi lumen] (R-HSA-1463558) GalNAc-MUC20 [Golgi lumen] (R-HSA-1463443) Core 2a (MUC20) [Golgi lumen] (R-HSA-6784267) Core 2 (MUC20) [Golgi lumen] (R-HSA-1462330) GalNAc-MUC20 [plasma membrane] (R-HSA-8858516) MUC20 [plasma membrane] (R-HSA-8851833)	0.527	2
UniProt:P08173 CHRM4	1	CHRM4 [plasma membrane] (R-HSA-390693)	0.527	2
UniProt:Q08J23 NSUN2	1	NSUN2 [nucleoplasm] (R-HSA-6782382)	0.483	2

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