Reactome | Polyglycyl-TUBB2B [cytosol]

Polyglycyl-TUBB2B [cytosol]

Stable Identifier

R-HSA-8867393

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBB2B, beta tubulin 2B

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Homo sapiens)
      - Polyglycylated microtubule [cytosol] (Homo sapiens)
        
        Polyglycylated microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglycyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglycyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglycyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglycyl-TUBB2B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BVA1 TUBB2B

Gene Names

TUBB2B

Chain

chain:1-445

Reference Genes

BioGPS Gene:347733 TUBB2B

COSMIC (genes):TUBB2B TUBB2B

CTD Gene:347733 TUBB2B

dbSNP Gene:347733 TUBB2B

ENSEMBL:ENSG00000137285 TUBB2B

ENSEMBL_homo_sapiens_GENE:ENSG00000137285.11 TUBB2B

HGNC:30829 TUBB2B

KEGG Gene (Homo sapiens):347733 TUBB2B

Monarch:347733 TUBB2B

NCBI Gene:347733 TUBB2B

OMIM:612850 TUBB2B

UCSC:Q9BVA1 TUBB2B

Reference Transcript

RefSeq:NM_178012.4 TUBB2B

Other Identifiers

11725298_x_at

17015158

202154_PM_x_at

202154_x_at

209372_PM_x_at

209372_x_at

213476_3p_x_at

213476_PM_x_at

213476_x_at

214023_PM_x_at

214023_x_at

2939216

2939217

2939224

2939234

2939235

2939236

2939245

2939246

2939248

2939250

2939256

2939257

33678_i_at

347733

39332_at

4050505

429_f_at

471_f_at

8123651

A_23_P501276

A_24_P314477

GE60053

GO:0000166

GO:0000226

GO:0000278

GO:0001764

GO:0003824

GO:0003924

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005634

GO:0005737

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0007399

GO:0015630

GO:0016787

GO:0021987

GO:0023052

GO:0030154

GO:0043226

GO:0045171

GO:0046872

GO:0046982

GO:0048856

GO:0048870

GO:0050804

GO:0072686

GO:0098685

GO:1902669

GO:1990403

HMNXSV003055194

Hs.179661.3.S1_3p_x_at

Hs.179661.4.S1_3p_a_at

Hs.179661.4.S1_3p_x_at

ILMN_1680874

PH_hs_0023602

TC06001228.hg

TC06003365.hg

TC06003368.hg

TC06003369.hg

Participates

as a candidate of

Polyglycyl beta tubulin [cytosol] (Homo sapiens)

Other forms of this molecule

TUBB2B folding intermediate [cytosol]

TUBB2B unfolded [cytosol]

Polyglutamyl-TUBB2B [cytosol]

TUBB2B [axonemal microtubule]

TUBB2B [cytosol]

Inferred To

tubb2b [cytosol] (Xenopus tropicalis)

Polyglycyl-TUBB2A [cytosol] (Dictyostelium discoideum)

Polyglycyl-TUBB2A [cytosol] (Plasmodium falciparum)

Polyglycyl-TUBB2B [cytosol] (Mus musculus)

Polyglycyl-TUBB2B [cytosol] (Rattus norvegicus)

TUBB2B [cytosol] (Sus scrofa)

Modified Residues

Name

L-isoglutamyl-polyglycine at unknown position

PsiMod Name

L-isoglutamyl-polyglycine

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-isoglutamyl-polyglycine.

Cross References

RefSeq

NP_821080.1

OpenTargets

ENSG00000137285

GeneCards

Q9BVA1

HPA

ENSG00000137285-TUBB2B

Ensembl

ENSG00000137285, ENST00000259818, ENSP00000259818

PRO

Q9BVA1

Pharos - Targets

Q9BVA1

Orphanet

18462

PDB

6E7C, 7ZCW

HMDB Protein

HMDBP08603

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54764 EPHA4	2	EPHA4 [plasma membrane] (R-HSA-2682325) p-Y596,Y602-EPHA4 [plasma membrane] (R-HSA-3928352)	0.643	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	5
UniProt:Q8N0Z6 TTC5	3	TTC5 [nucleoplasm] (R-HSA-6804264) p-S203-TTC5 [nucleoplasm] (R-HSA-6804261) p-S203,S221-TTC5 [nucleoplasm] (R-HSA-6804259)	0.527	3
UniProt:Q9HC35 EML4	12	EML4 [cytosol] (R-HSA-9647741) p-S,T-EML4 [cytosol] (R-HSA-9648096) EML4(1-496)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699812) EML4(1-223)-ALK(1059-1620) fusion [cytosol] (R-HSA-9699862) EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol] (R-HSA-9699813) EML4(1-780)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9716113) EML4(1-569)-p-7Y-ALK(1078-1620) fusion [cytosol] (R-HSA-9716116) EML4(1-223)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9699903) EML4(1-223)insKMSTREKNSQV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9699885) EML4(1-486)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699918) EML4(1-569)-ALK(1078-1620) fusion [cytosol] (R-HSA-9716112) EML4(1-780)-ALK(1058-1620) fusion [cytosol] (R-HSA-9716119)	0.527	3
UniProt:P36404 ARL2	2	ARL2 [cytosol] (R-HSA-5216230) ARL2 [mitochondrial matrix] (R-HSA-5250216)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	3

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